Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 368413..368932 Replicon chromosome
Accession NZ_CP091147
Organism Pseudomonas avellanae strain NCPPB 4222

Toxin (Protein)


Gene name relE Uniprot ID A0A0P9QT03
Locus tag L2Y01_RS01825 Protein ID WP_024420904.1
Coordinates 368642..368932 (+) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3M5TFX3
Locus tag L2Y01_RS01820 Protein ID WP_005621697.1
Coordinates 368413..368652 (+) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y01_RS01795 (L2Y01_01795) 364211..364705 - 495 WP_005621707.1 hypothetical protein -
L2Y01_RS01800 (L2Y01_01800) 364865..365404 + 540 WP_005621705.1 GNAT family N-acetyltransferase -
L2Y01_RS01805 (L2Y01_01805) 365592..366224 + 633 WP_005621703.1 DUF4062 domain-containing protein -
L2Y01_RS01810 (L2Y01_01810) 366217..367656 + 1440 WP_005621701.1 putative DNA binding domain-containing protein -
L2Y01_RS01815 (L2Y01_01815) 367776..368237 + 462 WP_005621698.1 GNAT family N-acetyltransferase -
L2Y01_RS01820 (L2Y01_01820) 368413..368652 + 240 WP_005621697.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L2Y01_RS01825 (L2Y01_01825) 368642..368932 + 291 WP_024420904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2Y01_RS01830 (L2Y01_01830) 369020..369139 + 120 Protein_364 GNAT family N-acetyltransferase -
L2Y01_RS01835 (L2Y01_01835) 369161..369898 - 738 WP_024420903.1 hypothetical protein -
L2Y01_RS01840 (L2Y01_01840) 370256..370597 + 342 WP_003380754.1 DUF5713 family protein -
L2Y01_RS01845 (L2Y01_01845) 370674..371288 + 615 WP_005621689.1 histidine phosphatase family protein -
L2Y01_RS01850 (L2Y01_01850) 371469..371711 + 243 WP_024420901.1 hypothetical protein -
L2Y01_RS01855 (L2Y01_01855) 371701..371985 + 285 WP_024420900.1 type II toxin-antitoxin system RelE/ParE family toxin -
L2Y01_RS01860 (L2Y01_01860) 372048..372590 - 543 WP_024420899.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11145.00 Da        Isoelectric Point: 10.2588

>T232852 WP_024420904.1 NZ_CP091147:368642-368932 [Pseudomonas avellanae]
MTYSLEFDARALKEWHKLGDTVRQQLKKKLATILVAPRVEANRLHALPDCYKIKLRSSGYRLVYQVIDQQVVVFVVAVDK
RERDEVYRKAADRLGG

Download         Length: 291 bp

>T232852 NZ_CP128388:700173-700361 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATTTTTGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8983.40 Da        Isoelectric Point: 4.6017

>AT232852 WP_005621697.1 NZ_CP091147:368413-368652 [Pseudomonas avellanae]
MASINVRIDDDLKARAYLELEKLGVTPSELLRQTLQYVAERGQLPFKTVLMTEEDEVLLATVRERLAAPQRVKVSLDDL

Download         Length: 240 bp

>AT232852 NZ_CP128388:699885-700145 [Staphylococcus aureus]
ATGAATAACATTTTGTTAAATGCTATCAATATAGTTATTACTACCACTTTTGTTATCTTTAATATTTTAATCACATATAA
TAAAGATTTAGATGATTTATGTTGGCTCCTGCCTGGTATTATCATTTGTGGTGTGATACTCATAGTATCCTTTACCATTG
CAATGATAACTAAAAACTGGTTAAGTGAAATATTATTTTTTATAAATATCGTACTCGTTCTCTATTACATTTATCCTATT
TTTTATAGTTTTATAGGTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P9QT03

Antitoxin

Source ID Structure
AlphaFold DB A0A3M5TFX3

References