Detailed information of TA system TA232845

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 44831..45327
• Replicon: plasmid p1NCPPB3491
• Accession: NZ_CP091144
• Organism: Pseudomonas avellanae strain NCPPB 3491

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: L2Y00_RS28555
• Protein ID: WP_024419628.1
• Coordinates: 44831..45139 (-)
• Length: 103 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: Q48BA1
• Locus tag: L2Y00_RS28560
• Protein ID: WP_002556028.1
• Coordinates: 45139..45327 (-)
• Length: 63 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2Y00_RS28525 (L2Y00_28525)	40440..40766	+	327	WP_005622105.1	hypothetical protein	-
L2Y00_RS28530 (L2Y00_28530)	41023..41688	+	666	WP_005622107.1	XopO/AvrRps4 family type III secretion system effector	-
L2Y00_RS28535 (L2Y00_28535)	42408..42578	-	171	Protein_47	hypothetical protein	-
L2Y00_RS28540 (L2Y00_28540)	42559..42840	-	282	WP_015062535.1	hypothetical protein	-
L2Y00_RS28545 (L2Y00_28545)	42957..44261	-	1305	WP_145915128.1	hypothetical protein	-
L2Y00_RS28550 (L2Y00_28550)	44337..44480	+	144	Protein_50	type II toxin-antitoxin system RelE/ParE family toxin	-
L2Y00_RS28555 (L2Y00_28555)	44831..45139	-	309	WP_024419628.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L2Y00_RS28560 (L2Y00_28560)	45139..45327	-	189	WP_002556028.1	hypothetical protein	Antitoxin
L2Y00_RS28565 (L2Y00_28565)	45505..45696	-	192	Protein_53	helix-turn-helix domain-containing protein	-
L2Y00_RS28570 (L2Y00_28570)	45877..46656	-	780	WP_249740311.1	transposase	-
L2Y00_RS28575 (L2Y00_28575)	46722..49610	-	2889	WP_249740312.1	Tn3 family transposase	-
L2Y00_RS28580 (L2Y00_28580)	49704..50309	+	606	WP_024421557.1	recombinase family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Conjugative plasmid	-	-	1..105919	105919

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 103 a.a.
• Molecular weight: 11793.52 Da
• Isoelectric Point: 7.3147

>T232845 WP_024419628.1 NZ_CP091144:c45139-44831 [Pseudomonas avellanae]
MLPVVWLSPALDDLREIATYIAWENPSAARRLKSLLQEAIEPVAEHPYLYRSGRAPGTRELVAHPNYVLVYRVTLERIEV
VNVIHARQEYPGFGEQWNRKPT

Nucleotide

• Length: 309 bp

>T232845 NZ_CP128262:19748-20053 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGCAGTTTAAGGTTTACACCTATAAAAGAGAGAGCCGTTATCGTCTGTTTGTGGATGTCCAGAGTGACATTATTGACAC
GCCCGGGCGACGGATGGTGATCCCCCTGGCCAGTGCACGTCTGTTGTCAGATAAGGTCTCCCGTGAGCTTTACCCGGTGG
TGCATGTCGGGGATGAAAGCTGGCGCATGATGACCACCGATATGGCCAGTGTGCCGGTCTCCGTTATCGGGGAGGAAGTG
GCTGATCTCAGCCACCGAGAAAATGACATCAAAAATGCCATTAACCTGATGTTCTGGGGAATATAA

Antitoxin

Protein

• Length: 63 a.a.
• Molecular weight: 7043.86 Da
• Isoelectric Point: 4.2550

>AT232845 WP_002556028.1 NZ_CP091144:c45327-45139 [Pseudomonas avellanae]
MANLSPIVSEFETDEQAASYDRWFRAKVAASLADPRPAIPHDEVMAEIEALIDQVETQREKR

Nucleotide

• Length: 189 bp

>AT232845 NZ_CP128262:19528-19746 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGAAGCAGCGCATTACAGTCACCGTCGACAGTGACAGCTATCAGTTGCTCAAGGCATATGATGTCAATATCTCCGGGCT
GGTAAGCACCACCCTGCAGAATGAAGCCCGTCGTCTGCGTGCCGAACGCTGGCAGGCAGAAAATCAGGAAGGGATGGCTG
AGGTCGCCCGGTTTATTGAAATGAACGGCTCTTTTGCCGACGAGAACAGGGACTGGTGA

Structures

Antitoxin

• AlphaFold DB: A0A2G9KWB9