Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/ParE-RelB
Location 4345419..4345938 Replicon chromosome
Accession NZ_CP091143
Organism Pseudomonas avellanae strain NCPPB 3491

Toxin (Protein)


Gene name relE Uniprot ID A0A0P9QT03
Locus tag L2Y00_RS19610 Protein ID WP_024420904.1
Coordinates 4345419..4345709 (-) Length 97 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A3M5TFX3
Locus tag L2Y00_RS19615 Protein ID WP_005621697.1
Coordinates 4345699..4345938 (-) Length 80 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2Y00_RS19575 (L2Y00_19575) 4341761..4342303 + 543 WP_024420899.1 hypothetical protein -
L2Y00_RS19580 (L2Y00_19580) 4342366..4342650 - 285 WP_024420900.1 type II toxin-antitoxin system RelE/ParE family toxin -
L2Y00_RS19585 (L2Y00_19585) 4342640..4342882 - 243 WP_024420901.1 hypothetical protein -
L2Y00_RS19590 (L2Y00_19590) 4343063..4343677 - 615 WP_005621689.1 histidine phosphatase family protein -
L2Y00_RS19595 (L2Y00_19595) 4343754..4344095 - 342 WP_003380754.1 DUF5713 family protein -
L2Y00_RS19600 (L2Y00_19600) 4344453..4345190 + 738 WP_005621692.1 hypothetical protein -
L2Y00_RS19605 (L2Y00_19605) 4345212..4345331 - 120 Protein_3883 GNAT family N-acetyltransferase -
L2Y00_RS19610 (L2Y00_19610) 4345419..4345709 - 291 WP_024420904.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2Y00_RS19615 (L2Y00_19615) 4345699..4345938 - 240 WP_005621697.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L2Y00_RS19620 (L2Y00_19620) 4346114..4346575 - 462 WP_005621698.1 GNAT family N-acetyltransferase -
L2Y00_RS19625 (L2Y00_19625) 4346695..4348134 - 1440 WP_005621701.1 putative DNA binding domain-containing protein -
L2Y00_RS19630 (L2Y00_19630) 4348127..4348759 - 633 WP_005621703.1 DUF4062 domain-containing protein -
L2Y00_RS19635 (L2Y00_19635) 4348947..4349486 - 540 WP_005621705.1 GNAT family N-acetyltransferase -
L2Y00_RS19640 (L2Y00_19640) 4349646..4350140 + 495 WP_005621707.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(5-81)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(1-70)


Sequences

Toxin        


Download         Length: 97 a.a.        Molecular weight: 11145.00 Da        Isoelectric Point: 10.2588

>T232840 WP_024420904.1 NZ_CP091143:c4345709-4345419 [Pseudomonas avellanae]
MTYSLEFDARALKEWHKLGDTVRQQLKKKLATILVAPRVEANRLHALPDCYKIKLRSSGYRLVYQVIDQQVVVFVVAVDK
RERDEVYRKAADRLGG

Download         Length: 291 bp

>T232840 NZ_CP128261:c4053299-4053012 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA

Antitoxin


Download         Length: 80 a.a.        Molecular weight: 8983.40 Da        Isoelectric Point: 4.6017

>AT232840 WP_005621697.1 NZ_CP091143:c4345938-4345699 [Pseudomonas avellanae]
MASINVRIDDDLKARAYLELEKLGVTPSELLRQTLQYVAERGQLPFKTVLMTEEDEVLLATVRERLAAPQRVKVSLDDL

Download         Length: 240 bp

>AT232840 NZ_CP128261:c4053025-4052723 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0P9QT03

Antitoxin

Source ID Structure
AlphaFold DB A0A3M5TFX3

References