Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 4345419..4345938 | Replicon | chromosome |
| Accession | NZ_CP091143 | ||
| Organism | Pseudomonas avellanae strain NCPPB 3491 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | A0A0P9QT03 |
| Locus tag | L2Y00_RS19610 | Protein ID | WP_024420904.1 |
| Coordinates | 4345419..4345709 (-) | Length | 97 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | A0A3M5TFX3 |
| Locus tag | L2Y00_RS19615 | Protein ID | WP_005621697.1 |
| Coordinates | 4345699..4345938 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2Y00_RS19575 (L2Y00_19575) | 4341761..4342303 | + | 543 | WP_024420899.1 | hypothetical protein | - |
| L2Y00_RS19580 (L2Y00_19580) | 4342366..4342650 | - | 285 | WP_024420900.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| L2Y00_RS19585 (L2Y00_19585) | 4342640..4342882 | - | 243 | WP_024420901.1 | hypothetical protein | - |
| L2Y00_RS19590 (L2Y00_19590) | 4343063..4343677 | - | 615 | WP_005621689.1 | histidine phosphatase family protein | - |
| L2Y00_RS19595 (L2Y00_19595) | 4343754..4344095 | - | 342 | WP_003380754.1 | DUF5713 family protein | - |
| L2Y00_RS19600 (L2Y00_19600) | 4344453..4345190 | + | 738 | WP_005621692.1 | hypothetical protein | - |
| L2Y00_RS19605 (L2Y00_19605) | 4345212..4345331 | - | 120 | Protein_3883 | GNAT family N-acetyltransferase | - |
| L2Y00_RS19610 (L2Y00_19610) | 4345419..4345709 | - | 291 | WP_024420904.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| L2Y00_RS19615 (L2Y00_19615) | 4345699..4345938 | - | 240 | WP_005621697.1 | type II toxin-antitoxin system RelB/DinJ family antitoxin | Antitoxin |
| L2Y00_RS19620 (L2Y00_19620) | 4346114..4346575 | - | 462 | WP_005621698.1 | GNAT family N-acetyltransferase | - |
| L2Y00_RS19625 (L2Y00_19625) | 4346695..4348134 | - | 1440 | WP_005621701.1 | putative DNA binding domain-containing protein | - |
| L2Y00_RS19630 (L2Y00_19630) | 4348127..4348759 | - | 633 | WP_005621703.1 | DUF4062 domain-containing protein | - |
| L2Y00_RS19635 (L2Y00_19635) | 4348947..4349486 | - | 540 | WP_005621705.1 | GNAT family N-acetyltransferase | - |
| L2Y00_RS19640 (L2Y00_19640) | 4349646..4350140 | + | 495 | WP_005621707.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 97 a.a. Molecular weight: 11145.00 Da Isoelectric Point: 10.2588
>T232840 WP_024420904.1 NZ_CP091143:c4345709-4345419 [Pseudomonas avellanae]
MTYSLEFDARALKEWHKLGDTVRQQLKKKLATILVAPRVEANRLHALPDCYKIKLRSSGYRLVYQVIDQQVVVFVVAVDK
RERDEVYRKAADRLGG
MTYSLEFDARALKEWHKLGDTVRQQLKKKLATILVAPRVEANRLHALPDCYKIKLRSSGYRLVYQVIDQQVVVFVVAVDK
RERDEVYRKAADRLGG
Download Length: 291 bp
>T232840 NZ_CP128261:c4053299-4053012 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
ATGCCGATGGAGTTTGAATGGGATGCGAACAAGGCTAAAAGCAACCTGAGGAAGCACGGTGTCCGTTTTGAGGATGCGGT
ACTGGTGTTTGACGATCCCCGACACCTGTCACGTCAGGAGCGTTATGAGAATGGAGAATATCGTTGGCAGACCCTCGGCC
TTGTTCATGGCATTGTGGTCATTCTGGTTGCTCATAGCGTTCGGTTCGAAAGTGGTTTTGAAGTTATCCGTATCATCAGC
GCCCGCAAGGCAGACAGAAAAGAGAGGAATCGTTATGAGCATGGTTAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 8983.40 Da Isoelectric Point: 4.6017
>AT232840 WP_005621697.1 NZ_CP091143:c4345938-4345699 [Pseudomonas avellanae]
MASINVRIDDDLKARAYLELEKLGVTPSELLRQTLQYVAERGQLPFKTVLMTEEDEVLLATVRERLAAPQRVKVSLDDL
MASINVRIDDDLKARAYLELEKLGVTPSELLRQTLQYVAERGQLPFKTVLMTEEDEVLLATVRERLAAPQRVKVSLDDL
Download Length: 240 bp
>AT232840 NZ_CP128261:c4053025-4052723 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG
ATGAGCATGGTTAAACATAAACGCGGCAACGCATCCGCGCTGAGTGCTCAGCATGAGGCTGAACTGAAGGCGCTGGCGAA
AAAATCAGATGATGAGATTGATTACAGCGACATTCCCGCTTCGGAGGATGGGCAGTGGTCTGAAGCAGTGCGTGGTAAGT
TTTTTCGCCCGTTAAAAACTCAGGCCTCGGTGCGTATTGACGCCGATGTGATGGAGTGGCTGAAACGGCCAGGAAAAGGC
TACCAGACGCGGCTCAATGCCATTCTGCGCGAGGCGATGCTGCGCGAGCAAAATAAGAAATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0P9QT03 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A3M5TFX3 |