Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 3827011..3827630 Replicon chromosome
Accession NC_011666
Organism Methylocella silvestris BL2

Toxin (Protein)


Gene name vapC Uniprot ID B8ETM1
Locus tag MSIL_RS17685 Protein ID WP_012592442.1
Coordinates 3827011..3827403 (-) Length 131 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MSIL_RS17690 Protein ID WP_012592443.1
Coordinates 3827400..3827630 (-) Length 77 a.a.

Genomic Context

MSIL_RS17670MSIL_RS17675MSIL_RS17680MSIL_RS17695MSIL_RS17700MSIL_RS17705MSIL_RS17710MSIL_RS17685MSIL_RS17690
Location: 3822981..3824477 (1497 bp)
Type: Others
Protein ID: WP_012592439.1
Location: 3824479..3825561 (1083 bp)
Type: Others
Protein ID: WP_012592440.1
Location: 3825564..3826949 (1386 bp)
Type: Others
Protein ID: WP_012592441.1
Location: 3827868..3829064 (1197 bp)
Type: Others
Protein ID: WP_012592444.1
Location: 3829061..3830176 (1116 bp)
Type: Others
Protein ID: WP_012592445.1
Location: 3830173..3831579 (1407 bp)
Type: Others
Protein ID: WP_012592446.1
Location: 3831620..3832567 (948 bp)
Type: Others
Protein ID: WP_012592447.1
Location: 3827011..3827403 (393 bp)
Type: Toxin
Protein ID: WP_012592442.1
Location: 3827400..3827630 (231 bp)
Type: Antitoxin
Protein ID: WP_012592443.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MSIL_RS176703822981..3824477+1497WP_012592439.1UDP-N-acetylmuramoylalanyl-D-glutamyl-2, 6-diaminopimelate--D-alanyl-D-alanine ligase-
MSIL_RS176753824479..3825561+1083WP_012592440.1phospho-N-acetylmuramoyl-pentapeptide- transferase-
MSIL_RS176803825564..3826949+1386WP_012592441.1UDP-N-acetylmuramoyl-L-alanine--D-glutamate ligase-
MSIL_RS176853827011..3827403-393WP_012592442.1type II toxin-antitoxin system VapC family toxinToxin
MSIL_RS176903827400..3827630-231WP_012592443.1hypothetical proteinAntitoxin
MSIL_RS176953827868..3829064+1197WP_012592444.1putative lipid II flippase FtsW-
MSIL_RS177003829061..3830176+1116WP_012592445.1undecaprenyldiphospho-muramoylpentapeptide beta-N-acetylglucosaminyltransferase-
MSIL_RS177053830173..3831579+1407WP_012592446.1UDP-N-acetylmuramate--L-alanine ligase-
MSIL_RS177103831620..3832567+948WP_012592447.1UDP-N-acetylmuramate dehydrogenase-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Pae0151-like, PIN domain

(3-124)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 131 a.a.        Molecular weight: 14313.54 Da        Isoelectric Point: 6.8812

>T23284 WP_012592442.1 NC_011666:c3827403-3827011 [Methylocella silvestris BL2]
MIVVDASALLEALLRTPSAKTVEDRLFAAGQTLHAPHLLDVEVAQVIRRYALSGEIDRARGGLALADLADLPLRRYPHDF
LLPRIWDLRNNLTAYDAAYVALAEALDAPLLTRDRRLAAAAGHRARIELV

Download         Length: 393 bp

>T23284 NC_011666:c3827403-3827011 [Methylocella silvestris BL2]
TTGATCGTCGTCGACGCTTCCGCGCTTCTTGAAGCCCTTCTACGCACGCCCTCGGCGAAAACGGTGGAAGATCGGCTGTT
CGCCGCTGGTCAAACGCTTCACGCGCCGCATCTGCTCGATGTCGAAGTCGCGCAAGTGATCCGGCGTTACGCGTTGAGCG
GCGAGATCGACAGAGCGCGCGGCGGCTTGGCCCTCGCCGACCTGGCGGACCTTCCTTTGCGGCGATATCCGCACGATTTT
CTTCTGCCGCGCATTTGGGATTTGCGGAACAATCTGACGGCTTATGACGCCGCCTATGTCGCGCTGGCCGAGGCGCTTGA
CGCTCCGCTGCTGACGCGTGACCGGCGTTTAGCCGCGGCCGCCGGCCATCGCGCGCGGATCGAACTGGTTTAA

Antitoxin


Download         Length: 77 a.a.        Molecular weight: 8626.84 Da        Isoelectric Point: 8.7715

>AT23284 WP_012592443.1 NC_011666:c3827630-3827400 [Methylocella silvestris BL2]
MGVMIQIRNVPEALHRELKSRAALAGMSLSDYLLSEIRQTAERPTIEELRARLRSRTETDPSVPPAEAVRAERDRN

Download         Length: 231 bp

>AT23284 NC_011666:c3827630-3827400 [Methylocella silvestris BL2]
ATGGGAGTAATGATCCAGATCCGCAATGTCCCCGAGGCGCTGCATCGCGAGTTGAAGTCGCGCGCCGCTCTGGCCGGCAT
GTCATTGTCCGACTATCTGCTCAGCGAGATTCGTCAGACAGCGGAGCGGCCGACGATTGAAGAGTTGCGGGCGCGCTTGC
GCAGCCGCACGGAAACGGATCCTTCCGTGCCCCCAGCCGAAGCGGTTCGCGCCGAGCGCGACCGCAATTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
AlphaFold DBB8ETM1

Antitoxin

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Source
ID
Structure
No matching records found

References