Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/PIN(toxin)
Location 2076944..2077623 Replicon chromosome
Accession NZ_CP091139
Organism Microbacterium sp. KUDC0405

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2X98_RS11315 Protein ID WP_259610975.1
Coordinates 2077189..2077623 (+) Length 145 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag L2X98_RS11310 Protein ID WP_259610974.1
Coordinates 2076944..2077192 (+) Length 83 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2X98_RS11290 (L2X98_28055) 2073637..2073858 + 222 WP_259610971.1 type II toxin-antitoxin system VapB family antitoxin -
L2X98_RS11295 (L2X98_28060) 2073891..2074289 + 399 WP_259610972.1 VOC family protein -
L2X98_RS11300 (L2X98_28065) 2074296..2074697 - 402 WP_259610973.1 VOC family protein -
L2X98_RS11305 (L2X98_28070) 2074798..2076883 + 2086 Protein_2235 DNA helicase RecQ -
L2X98_RS11310 (L2X98_28075) 2076944..2077192 + 249 WP_259610974.1 hypothetical protein Antitoxin
L2X98_RS11315 (L2X98_28080) 2077189..2077623 + 435 WP_259610975.1 PIN domain-containing protein Toxin
L2X98_RS11320 (L2X98_28085) 2077675..2079454 + 1780 Protein_2238 glycoside hydrolase family 3 C-terminal domain-containing protein -
L2X98_RS11325 (L2X98_28090) 2079708..2079962 + 255 Protein_2239 glucuronate isomerase -
L2X98_RS11330 (L2X98_28095) 2080027..2081079 + 1053 WP_259613290.1 glucuronate isomerase -
L2X98_RS11335 (L2X98_28100) 2081079..2082425 + 1347 WP_259613291.1 mannitol dehydrogenase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(3-134)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 145 a.a.        Molecular weight: 15735.00 Da        Isoelectric Point: 6.2171

>T232835 WP_259610975.1 NZ_CP091139:2077189-2077623 [Microbacterium sp. KUDC0405]
MKLVDTNVLVYAVVSDAPHHARSKEWLERAFGGVDTVLLPWVSLIGFIRIVSNPRIHESPVAVDEALRVVDEWLERAVSV
APVPDARHPHRMRELLTPIAASGGNIVNDAHLAALAVQYGATVVTFDSDFGRFPGVKWEQPGPG

Download         Length: 435 bp

>T232835 NZ_CP128261:c1004389-1003862 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGATGTTTACAGACTGGCATGAGGCCGCGATAGGGAAAACCCACAATCGAATGAATTTTGATTGTGGGGATGCCGATCT
GAACCAATTCCTACAACGCCATGCACTACAAAATCATGAGAAAGGGACAACGAAAACCTATGTTGCGCTTGATAATTCGG
ATATTACACGTATCCACGGCTTTTACTCAGTCAGTCCTGCATCACTGATATATGCACAGGTTCCCGGCGCAATCAGCAAA
GGATTAGGGAGATATGATGTGCCAGTGTTTCGTCTGGGTCGTTTAGCCGTAGACAAATCTATGCAGGGGCAAGGGCTGGG
AGCACAACTTTTGTTATCTGCCGGAAAGCGTTGCATACAGGCGGCTTTGCAGGTCGGCGGCGTAGCCCTGCTTATTGATG
CCAAAAATAAACAGGTCTGCGACTGGTACAAAGGATTTGGCGCAGTACCATTAAACGATCAACCCCTTTCCTTGTTGCTG
TCGTTTAAAACGCTTTATGCTGCTTTATCTGCATCTGGTAGGTTATGA

Antitoxin


Download         Length: 83 a.a.        Molecular weight: 9451.85 Da        Isoelectric Point: 7.0145

>AT232835 WP_259610974.1 NZ_CP091139:2076944-2077192 [Microbacterium sp. KUDC0405]
MRTTITLTPEAESVIRRMMDERKLSFKEAVNSAILSAPRHEARERYVLPSFTLGTRVPLDDIKGLLGQLDDEDYLRKQEF
GK

Download         Length: 249 bp

>AT232835 NZ_CP128261:c1004676-1004386 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGAAAACCATGCCTCAGATAGCTATAGAATCTAACGAAAGACTGTCGTTACGTGTATCGACGGATGCCAAAAAGTTGAT
AGTCCGCGCTGCGGCAATCCAGCAAACCAACCTGACGGATTTTGTGGTCAGTAACGTACTACCTGTCGCACAGAAGATTG
TTGATGCCGCCGAACGGGTATATCTGACGGAGCGTGATACTCAAATGATCATGGAAATTTTAGATAACCCGCCAGCGCCG
AATGAAAAGCTTCTTGCCGCTGCTTTCGCCCTGCCGGACATGAAGAAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References