Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) mazEF/MazF(toxin)
Location 1559753..1560345 Replicon chromosome
Accession NZ_CP091139
Organism Microbacterium sp. KUDC0405

Toxin (Protein)


Gene name mazF Uniprot ID -
Locus tag L2X98_RS08410 Protein ID WP_259612952.1
Coordinates 1559753..1560124 (-) Length 124 a.a.

Antitoxin (Protein)


Gene name mazE Uniprot ID -
Locus tag L2X98_RS08415 Protein ID WP_259612953.1
Coordinates 1560121..1560345 (-) Length 75 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2X98_RS08385 (L2X98_25395) 1555692..1557188 - 1497 WP_259612951.1 FGGY family carbohydrate kinase -
L2X98_RS08390 (L2X98_25400) 1557577..1557801 - 225 Protein_1656 substrate-binding domain-containing protein -
L2X98_RS08395 (L2X98_25405) 1557914..1558474 - 561 Protein_1657 LacI family transcriptional regulator -
L2X98_RS08400 (L2X98_04100) 1558590..1559342 + 753 Protein_1658 DUF2961 domain-containing protein -
L2X98_RS08405 (L2X98_25410) 1559462..1559719 + 258 WP_259613257.1 DUF2961 domain-containing protein -
L2X98_RS08410 (L2X98_25415) 1559753..1560124 - 372 WP_259612952.1 type II toxin-antitoxin system PemK/MazF family toxin Toxin
L2X98_RS08415 (L2X98_25420) 1560121..1560345 - 225 WP_259612953.1 ribbon-helix-helix domain-containing protein Antitoxin
L2X98_RS08420 (L2X98_25425) 1560635..1561218 - 584 Protein_1662 TetR/AcrR family transcriptional regulator C-terminal domain-containing protein -
L2X98_RS08425 (L2X98_25430) 1561279..1561893 + 615 WP_259612954.1 biotin transporter BioY -
L2X98_RS08430 (L2X98_25435) 1561890..1562578 + 689 Protein_1664 energy-coupling factor ABC transporter ATP-binding protein -
L2X98_RS08435 (L2X98_25440) 1562572..1563173 + 602 Protein_1665 energy-coupling factor transporter transmembrane protein EcfT -
L2X98_RS08440 (L2X98_04150) 1563312..1564112 - 801 WP_259612955.1 carbohydrate ABC transporter permease -
L2X98_RS08445 (L2X98_04155) 1564046..1565143 - 1098 WP_259612956.1 sugar ABC transporter permease -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

mRNA interferase PemK-like

(10-120)

Antitoxin

Ribbon-helix-helix protein, CopG

(5-40)


Sequences

Toxin        


Download         Length: 124 a.a.        Molecular weight: 12889.87 Da        Isoelectric Point: 11.2212

>T232832 WP_259612952.1 NZ_CP091139:c1560124-1559753 [Microbacterium sp. KUDC0405]
MTGDGVTLVRRGAIVLVDLDPVSGSEASKTRPAVVVSNNTANAAAVRTRRGVITVVPITSSTARVFPFHVLLDADATGLS
HDSKAQAEQVRAVSIGRILRIVGWVPAEAMTQVDAALRLHLAL

Download         Length: 372 bp

>T232832 NZ_CP128261:206723-207208 [Salmonella enterica subsp. enterica serovar Heidelberg]
GTGGGACGTGTAACAGCACCAGAACCTTTGTCCGCTTTTCATCAGGTAGCTGAGTTCGTCAGCGGTGAAGCTGTGCTCGA
TGACTGGTTGAAGCAAAAGGGCCTCAAAAACCAGGCTCTCGGAGCGGCCAGAACATTTGTGGTGTGCAAGAAAGACACGA
AGCAAGTAGCCGGTTTTTACTCTCTGGCCACCGGTAGCGTCAACCATACAGAAGCGACAGGCAACCTTCGGCGTAACATG
CCAGATCCCATCCCTGTCATTATACTTGCCCGTCTTGCTGTCGATCTCTCATTCCATGGAAAAGGGCTTGGTGCTGATTT
ACTTCATGATGCAGTGCTTCGTTGCTATCGGGTTGCCGAGAATATTGGTGTACGTGCAATCATGGTTCATGCACTTACCG
AAGAAGCCAAAAATTTCTACATTCACCATGGTTTCAAATCATCACAAACTCAGCAGCGAACATTGTTCCTTAGGCTCCCT
CAATAG

Antitoxin


Download         Length: 75 a.a.        Molecular weight: 7611.30 Da        Isoelectric Point: 3.7178

>AT232832 WP_259612953.1 NZ_CP091139:c1560345-1560121 [Microbacterium sp. KUDC0405]
MGAKVSISLGEDDIAALDADVLAGRFASRSAAVQRALQLLRESELADAYAEAFGSWVDDGEAAAWDAAPDDGVA

Download         Length: 225 bp

>AT232832 NZ_CP128261:206448-206735 [Salmonella enterica subsp. enterica serovar Heidelberg]
ATGCTATACAAGGGGTGTCTCATGAAATCAGATGTTCAACTTAACCTTAGAGCTAAGGAATCGCAGCGGGCGCTCATTGA
TGCAGCTGCGGAAATCCTTCACAAGTCACGTACAGATTTCATTCTGGAAACGGCCTGCCAGGCTGCCGAGAAAGTGATCC
TTGACCGCCGTGTATTTAACTTTAACGATGAGCAATATGAGGAGTTCATCAATCTGCTTGATGCACCGGTCGCAGATGAT
CCCGTTATCGAAAAACTGCTGGCAAGGAAACCTCAGTGGGACGTGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References