Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapC-TsdA/VapC(toxin)
Location 373234..374049 Replicon chromosome
Accession NZ_CP091138
Organism Microbacterium sp. KUDC0406

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2X99_RS02005 Protein ID WP_236125280.1
Coordinates 373234..373647 (+) Length 138 a.a.

Antitoxin (Protein)


Gene name TsdA Uniprot ID -
Locus tag L2X99_RS02010 Protein ID WP_236125279.1
Coordinates 373777..374049 (+) Length 91 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2X99_RS01970 (L2X99_01970) 368747..369634 + 888 WP_236135567.1 arginase family protein -
L2X99_RS01975 (L2X99_01975) 369671..370012 - 342 WP_236125285.1 hypothetical protein -
L2X99_RS01980 (L2X99_01980) 370061..370288 - 228 WP_236125284.1 hypothetical protein -
L2X99_RS01985 (L2X99_01985) 370434..371078 + 645 WP_236125283.1 NAD(P)H-binding protein -
L2X99_RS01990 (L2X99_01990) 371083..371442 - 360 WP_236125282.1 YrdB family protein -
L2X99_RS01995 (L2X99_01995) 371570..372866 - 1297 Protein_386 DUF445 domain-containing protein -
L2X99_RS02000 (L2X99_02000) 372941..373231 + 291 WP_236125281.1 type II toxin-antitoxin system prevent-host-death family antitoxin -
L2X99_RS02005 (L2X99_02005) 373234..373647 + 414 WP_236125280.1 type II toxin-antitoxin system VapC family toxin Toxin
L2X99_RS02010 (L2X99_02010) 373777..374049 + 273 WP_236125279.1 metal-sensitive transcriptional regulator Antitoxin
L2X99_RS02015 (L2X99_02015) 374060..374962 - 903 WP_236135568.1 sugar kinase -
L2X99_RS02020 (L2X99_02020) 374959..376168 - 1210 Protein_391 MFS transporter -
L2X99_RS02025 (L2X99_02025) 376545..376778 + 234 WP_236125277.1 glutaredoxin-like protein NrdH -
L2X99_RS02030 (L2X99_02030) 376812..377246 + 435 WP_236125276.1 class Ib ribonucleoside-diphosphate reductase assembly flavoprotein NrdI -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-123)

Antitoxin

Metal-sensitive transcriptional repressor

(6-85)


Sequences

Toxin        


Download         Length: 138 a.a.        Molecular weight: 15453.56 Da        Isoelectric Point: 6.2365

>T232830 WP_236125280.1 NZ_CP091138:373234-373647 [Microbacterium sp. KUDC0406]
VYLLDTNAYSESRRPGLLGETMRTWLADTPPEVTFMSAITDYELERGVLHLQRRDPRQATALRGWLTTVRSGLEGRILSV
TPEIARVFARLDVPDRRPWADALIAATALHHDLTVVTRNEKDFDVPGLRVINPFSGD

Download         Length: 414 bp

>T232830 NZ_CP128260:5388541-5388795 [Pseudomonas fluorescens]
ATGAAAATCCAGTTCACGCCAACGGGCTGGGAAGACTACTTGTGGTTTCAACAAAACGATAAGGCCGGTCTCAAACGAAT
CAATCTTCTGATCAAAGCGATCCAGCGCCAACCCTTTGAAGGCTTGGGTAAACCGGAGCCGCTCAAGCACAACATGAGCG
GCTTCTGGTCACGGCGGATAACTGCCGAGCATCGCTTGGTCTATGCAATCGTAGACGGCGAAATCTGCGTCATAACTTGC
AGATTTCACTATTGA

Antitoxin


Download         Length: 91 a.a.        Molecular weight: 10536.97 Da        Isoelectric Point: 5.6017

>AT232830 WP_236125279.1 NZ_CP091138:373777-374049 [Microbacterium sp. KUDC0406]
VIEDIKKRALHRTSILEGQLRGIARMIENDEYCMDIITQSRAVQRSLESLNRLLLENHLRTHVTDMFEEGGEQREQAVDE
LLKAFDFHSK

Download         Length: 273 bp

>AT232830 NZ_CP128260:5388290-5388544 [Pseudomonas fluorescens]
ATGGACACTATCAACTACACCACGGCTCGTGCGCACTTGGCTGAAACCATGGATCGCGTGAATGAAGACTGCGCCCCACT
TCTGGTAACCCGCCAAAAAGGCGAGCCAGTAGTGATGATGTCTCTGGCCGAATACAACGCGCTGGAAGAAACGGCTTATC
TGCTGCGCTCTCCGGCCAATGCCGAGCGCTTGATCAAATCGATTGGCGAAATGCGCGCTGGAAAAGCGCAAGTCAGGCAA
CTGATCGAAGAATGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References