Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 148073..148599 | Replicon | plasmid unnamed2 |
| Accession | NZ_CP091127 | ||
| Organism | Serratia marcescens strain CM2015_854 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | L2D47_RS29035 | Protein ID | WP_000323025.1 |
| Coordinates | 148073..148360 (-) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | L2D47_RS29040 | Protein ID | WP_000534858.1 |
| Coordinates | 148360..148599 (-) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2D47_RS29000 (L2D47_28995) | 143744..144061 | - | 318 | WP_015065519.1 | hypothetical protein | - |
| L2D47_RS29005 (L2D47_29000) | 144076..144426 | - | 351 | WP_032425551.1 | hypothetical protein | - |
| L2D47_RS29010 (L2D47_29005) | 144423..144695 | - | 273 | WP_032425552.1 | hypothetical protein | - |
| L2D47_RS29015 (L2D47_29010) | 145435..146547 | + | 1113 | WP_001300563.1 | IS4-like element IS421 family transposase | - |
| L2D47_RS29020 (L2D47_29015) | 146742..146840 | - | 99 | WP_159224797.1 | Hok/Gef family protein | - |
| L2D47_RS29025 (L2D47_29020) | 146815..146871 | - | 57 | Protein_147 | modulator protein | - |
| L2D47_RS29030 (L2D47_29025) | 146972..148006 | + | 1035 | Protein_148 | IS481 family transposase | - |
| L2D47_RS29035 (L2D47_29030) | 148073..148360 | - | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| L2D47_RS29040 (L2D47_29035) | 148360..148599 | - | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| L2D47_RS29045 (L2D47_29040) | 148624..148722 | + | 99 | Protein_151 | protein YdfV | - |
| L2D47_RS29050 (L2D47_29045) | 148850..149215 | + | 366 | WP_009651956.1 | hypothetical protein | - |
| L2D47_RS29055 (L2D47_29050) | 149259..149996 | + | 738 | WP_008460272.1 | HupE/UreJ family protein | - |
| L2D47_RS29060 (L2D47_29055) | 150010..150699 | + | 690 | WP_004196322.1 | hypothetical protein | - |
| L2D47_RS29065 (L2D47_29060) | 150730..152106 | - | 1377 | Protein_155 | chromate efflux transporter | - |
| L2D47_RS29070 (L2D47_29065) | 152063..153040 | - | 978 | WP_004196334.1 | chromate resistance protein | - |
| L2D47_RS29075 (L2D47_29070) | 153070..153262 | + | 193 | Protein_157 | MFS transporter | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | - | - | 1..193603 | 193603 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T232827 WP_000323025.1 NZ_CP091127:c148360-148073 [Serratia marcescens]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T232827 NZ_CP128260:3808499-3808726 [Pseudomonas fluorescens]
ATTGAACAATACAACTCAAACGCTTCAGTGGCTCTGCAACGCAAGGTGGGTGCAGCAACGCAAAGGCTTTCATCAATCCC
CTATGGTTACCGGTACGGTCGAGTGCCAAGCACTCGGGAAATGGTGATCAATCCAAACTATCTGCTCGTCTATCGAGTGA
ACGGGCCCATCAAAATACTGACGTTAGTCCACACCCGACGACAATACCCACGAACTTCAGCAACATAA
ATTGAACAATACAACTCAAACGCTTCAGTGGCTCTGCAACGCAAGGTGGGTGCAGCAACGCAAAGGCTTTCATCAATCCC
CTATGGTTACCGGTACGGTCGAGTGCCAAGCACTCGGGAAATGGTGATCAATCCAAACTATCTGCTCGTCTATCGAGTGA
ACGGGCCCATCAAAATACTGACGTTAGTCCACACCCGACGACAATACCCACGAACTTCAGCAACATAA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT232827 WP_000534858.1 NZ_CP091127:c148599-148360 [Serratia marcescens]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT232827 NZ_CP128260:3808258-3808452 [Pseudomonas fluorescens]
ATGAGCATATTGCATTCCCCGTTTTACGCTGACTTCGAATCCGAAGAAGAGGCCGAGAGCTACGATCGCTGGTTTCGAGC
AAAAGTACAGGCTGCACTCGATGATCCTAGTCCTGGCATTCCCCATGAGGAAGCCATGATGCGGCTCGACCAACTATTAG
AAGAGAGACGCAAGAATCGACGCGCTGCCGCTTGA
ATGAGCATATTGCATTCCCCGTTTTACGCTGACTTCGAATCCGAAGAAGAGGCCGAGAGCTACGATCGCTGGTTTCGAGC
AAAAGTACAGGCTGCACTCGATGATCCTAGTCCTGGCATTCCCCATGAGGAAGCCATGATGCGGCTCGACCAACTATTAG
AAGAGAGACGCAAGAATCGACGCGCTGCCGCTTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|