Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | relBE/ParE-RelB |
| Location | 154539..155065 | Replicon | plasmid unnamed1 |
| Accession | NZ_CP091126 | ||
| Organism | Serratia marcescens strain CM2015_854 | ||
Toxin (Protein)
| Gene name | relE | Uniprot ID | S1EXL1 |
| Locus tag | L2D47_RS27525 | Protein ID | WP_000323025.1 |
| Coordinates | 154778..155065 (+) | Length | 96 a.a. |
Antitoxin (Protein)
| Gene name | relB | Uniprot ID | S1F6D3 |
| Locus tag | L2D47_RS27520 | Protein ID | WP_000534858.1 |
| Coordinates | 154539..154778 (+) | Length | 80 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2D47_RS27500 (L2D47_27495) | 150867..152105 | + | 1239 | WP_000219087.1 | IS110-like element ISEsa2 family transposase | - |
| L2D47_RS27505 (L2D47_27500) | 152581..153153 | + | 573 | WP_001515348.1 | cytochrome b/b6 domain-containing protein | - |
| L2D47_RS27510 (L2D47_27505) | 153353..154276 | + | 924 | WP_000167917.1 | cation diffusion facilitator family transporter | - |
| L2D47_RS27515 (L2D47_27510) | 154410..154514 | - | 105 | Protein_161 | protein YdfV | - |
| L2D47_RS27520 (L2D47_27515) | 154539..154778 | + | 240 | WP_000534858.1 | type II toxin-antitoxin system antitoxin RelB | Antitoxin |
| L2D47_RS27525 (L2D47_27520) | 154778..155065 | + | 288 | WP_000323025.1 | type II toxin-antitoxin system mRNA interferase RelE | Toxin |
| L2D47_RS27530 (L2D47_27525) | 155137..155295 | + | 159 | WP_001447866.1 | type I toxin-antitoxin system Hok family toxin | - |
| L2D47_RS27535 (L2D47_27530) | 155373..156482 | + | 1110 | Protein_165 | IS4-like element IS421 family transposase | - |
| L2D47_RS27540 (L2D47_27535) | 157250..157570 | - | 321 | WP_000332796.1 | hypothetical protein | - |
| L2D47_RS27545 (L2D47_27540) | 157852..158055 | - | 204 | WP_001015183.1 | hypothetical protein | - |
| L2D47_RS27550 (L2D47_27545) | 158102..158452 | - | 351 | WP_000743059.1 | hypothetical protein | - |
| L2D47_RS27555 (L2D47_27550) | 158512..159114 | - | 603 | WP_012695474.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Conjugative plasmid | blaTEM-1B / tet(D) / sul1 / qacE / ere(A) / aac(6')-IIc / aph(3')-Ia / mcr-9 / aph(6)-Id / aph(3'')-Ib / dfrA19 / aadA2 / blaSHV-12 | - | 1..295330 | 295330 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 96 a.a. Molecular weight: 11225.22 Da Isoelectric Point: 10.1967
>T232823 WP_000323025.1 NZ_CP091126:154778-155065 [Serratia marcescens]
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
MAYFLDFDERALKEWRKLGSTVREQLKKKLVEVLESPRIEANKLRGMPDCYKIKLRSSGYRLVYQVIDEKVVVFVISVGK
RERSEVYSEAVKRIL
Download Length: 288 bp
>T232823 NZ_CP128260:c546345-546031 [Pseudomonas fluorescens]
ATGATTTTTGTTGAGACTCGGATCTTTACCCGTCGAGTAAAAGAGCTGCTGGACGATGACACGTATGCCGCTTTTCAGAA
GCAACTGGTTGTAAGTCCTTCGATTGGCGATGTAATTGAAGGCACAGGCGGGATCCGCAAAACCCGAATCGCAGCGAAAG
GACACGGCAAGCGAGGCGGAGCACGGGTGATCTACTACCACTTCGTTTCGGCGTCACAAATCGGGTTATTGATGATCTAC
CCTAAAAATGAACAACACGATCTGTCCAGCGATGAGCGTAAAGCACTCAAGGTCTTGATCGAAAAATGGAGATGA
ATGATTTTTGTTGAGACTCGGATCTTTACCCGTCGAGTAAAAGAGCTGCTGGACGATGACACGTATGCCGCTTTTCAGAA
GCAACTGGTTGTAAGTCCTTCGATTGGCGATGTAATTGAAGGCACAGGCGGGATCCGCAAAACCCGAATCGCAGCGAAAG
GACACGGCAAGCGAGGCGGAGCACGGGTGATCTACTACCACTTCGTTTCGGCGTCACAAATCGGGTTATTGATGATCTAC
CCTAAAAATGAACAACACGATCTGTCCAGCGATGAGCGTAAAGCACTCAAGGTCTTGATCGAAAAATGGAGATGA
Antitoxin
Download Length: 80 a.a. Molecular weight: 9071.48 Da Isoelectric Point: 4.5230
>AT232823 WP_000534858.1 NZ_CP091126:154539-154778 [Serratia marcescens]
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
MGSINLRIDDELKARSYAALEKMGVTPSEALRLMLEYIADNERLPFKQTLLSDEDAELVEIVKERLRNPKPVRVTLDEL
Download Length: 240 bp
>AT232823 NZ_CP128260:c546028-545741 [Pseudomonas fluorescens]
ATGAGCAAATTTTTTGATGAGCTGATGGAAAGTGTGCAAGAGATGGACGAGATCGTACGAGGCGAGCGCACACCCTCTCG
CGAATTCCACGTTGATGCATTGCAGGTCAAAGAAATTCGTAAAGCTACCGGTTTGACCCAGGCCAAATTTGCGGCACTGA
TCGACGTCCAGCTCGGCACTCTACGAAATTGGGAACAGGGTCGTCGTGAGCCAACAGGGCCAGCCAAAGCCTTGTTGAAA
GCCATTCATAACGACCCGGTTCACGTACTGAATGCGCTGGCCTGCTAA
ATGAGCAAATTTTTTGATGAGCTGATGGAAAGTGTGCAAGAGATGGACGAGATCGTACGAGGCGAGCGCACACCCTCTCG
CGAATTCCACGTTGATGCATTGCAGGTCAAAGAAATTCGTAAAGCTACCGGTTTGACCCAGGCCAAATTTGCGGCACTGA
TCGACGTCCAGCTCGGCACTCTACGAAATTGGGAACAGGGTCGTCGTGAGCCAACAGGGCCAGCCAAAGCCTTGTTGAAA
GCCATTCATAACGACCCGGTTCACGTACTGAATGCGCTGGCCTGCTAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|