Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 5443853..5444424 Replicon chromosome
Accession NZ_CP091125
Organism Serratia marcescens strain CM2015_854

Toxin (Protein)


Gene name relE Uniprot ID A0A0G3SNA4
Locus tag L2D47_RS26215 Protein ID WP_038879053.1
Coordinates 5444149..5444424 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A086G7I5
Locus tag L2D47_RS26210 Protein ID WP_013811307.1
Coordinates 5443853..5444140 (+) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D47_RS26185 (L2D47_26180) 5439622..5440707 - 1086 WP_033636846.1 carbon-phosphorus lyase complex subunit PhnI -
L2D47_RS26190 (L2D47_26185) 5440707..5441288 - 582 WP_055312194.1 phosphonate C-P lyase system protein PhnH -
L2D47_RS26195 (L2D47_26190) 5441292..5441735 - 444 WP_019453314.1 phosphonate C-P lyase system protein PhnG -
L2D47_RS26200 (L2D47_26195) 5441736..5442464 - 729 WP_015376439.1 phosphonate metabolism transcriptional regulator PhnF -
L2D47_RS26205 (L2D47_26200) 5442692..5443747 + 1056 WP_055312195.1 permease -
L2D47_RS26210 (L2D47_26205) 5443853..5444140 + 288 WP_013811307.1 type II toxin-antitoxin system RelB/DinJ family antitoxin Antitoxin
L2D47_RS26215 (L2D47_26210) 5444149..5444424 + 276 WP_038879053.1 type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family Toxin
L2D47_RS26220 (L2D47_26215) 5444430..5444894 - 465 WP_055312196.1 anaerobic ribonucleoside-triphosphate reductase-activating protein -
L2D47_RS26225 (L2D47_26220) 5445063..5447201 - 2139 WP_055312197.1 anaerobic ribonucleoside-triphosphate reductase -
L2D47_RS26230 (L2D47_26225) 5447446..5448360 - 915 WP_048232521.1 LysR family transcriptional regulator -
L2D47_RS26235 (L2D47_26230) 5448467..5448991 + 525 WP_047729213.1 NAD(P)H-dependent oxidoreductase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-89)

Antitoxin

RelB antitoxin/Antitoxin DinJ

(4-70)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10736.52 Da        Isoelectric Point: 9.5103

>T232821 WP_038879053.1 NZ_CP091125:5444149-5444424 [Serratia marcescens]
MRIEWDNAALRDRERIFEFLYIFNPQAAVQADNEIDKAVKRLLDHPELGKPWYGKARKLLINKASLLLVYIIVDDVIKVF
SIAHQREKFPN

Download         Length: 276 bp

>T232821 NZ_CP128260:432418-432699 [Pseudomonas fluorescens]
ATGACCTATAAGCTCGAATTTCTGCCTTCCGCTCACAAAGAGTGGAACAAACTGGGTCATACGCTGCGTGATCAATTTAA
AAAGAAGCTGGCTGAGCGTCTTGAGCGTCCCCGTATTCCGGCTGACTCCCTCCACGGCATGCCTGATTGCTACAAGATCA
AACTCAAAGCGTCCGGTTATCGACTGGTTTACCAAGTGATCGAAGAGCGAGTGGTTGTCTCGGTAGTCGCCGTGGGTAAG
CGCGAGCGAGGCGACGTCTACGAAAACTCAAAAAGACGCTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 11032.33 Da        Isoelectric Point: 5.8001

>AT232821 WP_013811307.1 NZ_CP091125:5443853-5444140 [Serratia marcescens]
MESRIQFRIEDETKRLAQKAAEAKGTTLSEACRRLAEQMADEQRAAEEHENWLKDKVDAAFSRLHEGNAVYLSQQEVEES
MDAFKAKIRAKYDRK

Download         Length: 288 bp

>AT232821 NZ_CP128260:432183-432428 [Pseudomonas fluorescens]
ATGCAAAGTGTTCTGGCCGATATGGCTGTCAGTGTTTCTGAATTGAAGAAAAACCCCTCCGCAGTGCTAAACGGCGCGCA
CGGAGGAGCAGTTGCTGTCCTGAATCACAACCGGGTCATGGGCTACATGGTGCCGGCTGACGTTTACGAAGCCATGATGG
AGCGGCTCGATGATCTCGAGTTGGCAGAAATCGTTCGTTCTCGCAGTCACGAGACTCCCATACCGGTAAGCCTGGATGAC
CTATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0G3SNA4

Antitoxin

Source ID Structure
AlphaFold DB A0A086G7I5

References