Detailed information of TA system TA232820

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4001912..4002581
• Replicon: chromosome
• Accession: NZ_CP091125
• Organism: Serratia marcescens strain CM2015_854

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2D47_RS19505
• Protein ID: WP_055312420.1
• Coordinates: 4001912..4002334 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: L2D47_RS19510
• Protein ID: WP_019455657.1
• Coordinates: 4002315..4002581 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2D47_RS19485 (L2D47_19480)	3997802..3998320	+	519	WP_038871234.1	flavodoxin FldB	-
L2D47_RS19490 (L2D47_19485)	3998357..3999721	-	1365	WP_055312418.1	cell envelope integrity protein CreD	-
L2D47_RS19495 (L2D47_19490)	3999802..4001220	-	1419	WP_055312419.1	two-component system sensor histidine kinase CreC	-
L2D47_RS19500 (L2D47_19495)	4001217..4001912	-	696	WP_033644777.1	two-component system response regulator CreB	-
L2D47_RS19505 (L2D47_19500)	4001912..4002334	-	423	WP_055312420.1	protein YgfX	Toxin
L2D47_RS19510 (L2D47_19505)	4002315..4002581	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
L2D47_RS19515 (L2D47_19510)	4002902..4003894	+	993	WP_049199219.1	tRNA-modifying protein YgfZ	-
L2D47_RS19520 (L2D47_19515)	4003933..4004430	-	498	WP_049199221.1	DUF2165 domain-containing protein	-
L2D47_RS19525 (L2D47_19520)	4004579..4005253	-	675	WP_038871224.1	hemolysin III family protein	-
L2D47_RS19530 (L2D47_19525)	4005437..4006045	+	609	WP_025304127.1	HD domain-containing protein	-
L2D47_RS19535 (L2D47_19530)	4006078..4007004	-	927	WP_038871218.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16458.48 Da
• Isoelectric Point: 10.8114

>T232820 WP_055312420.1 NZ_CP091125:c4002334-4001912 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGLGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQSTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPTGDGEEA

Nucleotide

• Length: 423 bp

>T232820 NZ_CP128258:c50745-50464 [Escherichia coli]
ATGACCTATGAACTGGCTTTTGACCGTAGAGCACTGAAGGAATGGCAGAAACTCGGCCACACCATCCGTGAACAATTCAA
AAAGAAACTGGCAGAACGGCTGGAAAATCCACGCGTACCCGCAGCCCGGTTACATGGTCATGCTGATCGCTATAAAATCA
AACTTCGTGCATCTGGCTACAGACTTGTATACCAAGTCATTGATGAGAAAGTCGTTTTACTCGTTATTGCCGTTGGAAGA
AGGGAAAGCAGCGAAGTCTATCAGATCGCAGATTTGCGCTAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT232820 WP_019455657.1 NZ_CP091125:c4002581-4002315 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT232820 NZ_CP128258:c50986-50735 [Escherichia coli]
ATGAGCTATCAAATTCTGACAACCACAGCGGCCAGTATTACTGACCTGAAAAAAAATCCTATGGGAACCGTAGCTGAAGG
TGAAGGGGACGCTGTTGCGATCCTGAACCGAAACGAACCGGCGTTCTATTGCGTTCCACCAAAACTTTACGCCTACTATC
GGGAACTCGCTGAAGATGCTGAGTTAAACGCTGTTGCTGATGAGCGCATGAAAAACCCGGAAATTGTGAAGGTTAACCTG
GATGACCTATGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04