Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2037854..2038503 Replicon chromosome
Accession NC_011666
Organism Methylocella silvestris BL2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MSIL_RS09560 Protein ID WP_187148719.1
Coordinates 2037854..2038255 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MSIL_RS09565 Protein ID WP_041367834.1
Coordinates 2038252..2038503 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
MSIL_RS09525 2032940..2033854 - 915 WP_012590884.1 N-acetyl-gamma-glutamyl-phosphate reductase -
MSIL_RS09530 2034090..2034752 - 663 WP_012590885.1 CerR family C-terminal domain-containing protein -
MSIL_RS09535 2034749..2035465 - 717 WP_012590886.1 hypothetical protein -
MSIL_RS09540 2035764..2036243 - 480 WP_012590887.1 30S ribosomal protein S9 -
MSIL_RS09545 2036246..2036716 - 471 WP_012590888.1 50S ribosomal protein L13 -
MSIL_RS09550 2036907..2037335 - 429 WP_012590889.1 cupin domain-containing protein -
MSIL_RS09555 2037406..2037849 + 444 WP_012590890.1 CoA-binding protein -
MSIL_RS09560 2037854..2038255 - 402 WP_187148719.1 type II toxin-antitoxin system VapC family toxin Toxin
MSIL_RS09565 2038252..2038503 - 252 WP_041367834.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
MSIL_RS09570 2038546..2039625 - 1080 WP_012590893.1 COX15/CtaA family protein -
MSIL_RS09575 2039805..2040014 + 210 WP_012590894.1 DUF2842 domain-containing protein -
MSIL_RS09580 2040018..2041451 - 1434 WP_012590895.1 LPS biosynthesis protein -
MSIL_RS09585 2041540..2042496 - 957 WP_012590896.1 bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(15-55)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14354.60 Da        Isoelectric Point: 6.9548

>T23282 WP_187148719.1 NC_011666:c2038255-2037854 [Methylocella silvestris BL2]
MTRYMLDTNILSDLIKNPRGRAAARIEKVGEGDICTSIIVAAELRYGCAKKGSPRLRKVVEDILGEMTVLAFDAPADVEY
GRLRAELEAAGLTIGGNDLLIASHARAVGATIVTANLQEFTRVNGLKVENWLA

Download         Length: 402 bp

>T23282 NC_011666:c2038255-2037854 [Methylocella silvestris BL2]
TTGACGCGCTATATGCTCGACACGAACATCCTTTCCGACCTGATCAAGAATCCGCGCGGCCGGGCGGCGGCGCGGATCGA
GAAAGTCGGCGAGGGCGACATCTGCACCAGCATCATCGTTGCTGCGGAACTGCGCTATGGATGCGCCAAAAAGGGATCTC
CACGCCTCAGGAAAGTGGTGGAAGACATCCTTGGAGAAATGACGGTGCTCGCGTTCGACGCTCCGGCCGACGTCGAATAT
GGCAGGCTCCGCGCGGAGCTTGAGGCGGCGGGTCTGACCATCGGCGGCAACGATCTGCTGATCGCATCGCACGCCCGCGC
GGTAGGAGCGACGATCGTCACCGCGAATCTGCAGGAGTTTACCCGCGTCAATGGCCTGAAGGTCGAGAATTGGCTCGCTT
AG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9456.91 Da        Isoelectric Point: 4.5348

>AT23282 WP_041367834.1 NC_011666:c2038503-2038252 [Methylocella silvestris BL2]
MLEVSVSEQRRVKLFRNGRNQAVRIPVEFELPGDEAIMSRDGDRLVIEPTRKRGLLALLATLEPLEEALCQIEDRPVAPE
DIF

Download         Length: 252 bp

>AT23282 NC_011666:c2038503-2038252 [Methylocella silvestris BL2]
ATGCTGGAGGTGTCCGTGTCAGAGCAAAGACGCGTCAAGCTGTTCAGAAATGGCCGCAATCAGGCCGTCCGCATTCCCGT
CGAATTTGAATTGCCCGGCGATGAGGCGATCATGAGCCGGGACGGCGACCGGCTGGTCATTGAGCCAACGCGCAAACGCG
GCTTGCTGGCGCTACTCGCAACGCTCGAGCCGCTCGAGGAGGCGCTTTGCCAGATCGAGGATCGGCCGGTCGCGCCTGAA
GACATATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References