Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 2037854..2038503 Replicon chromosome
Accession NC_011666
Organism Methylocella silvestris BL2

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag MSIL_RS09560 Protein ID WP_187148719.1
Coordinates 2037854..2038255 (-) Length 134 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID -
Locus tag MSIL_RS09565 Protein ID WP_041367834.1
Coordinates 2038252..2038503 (-) Length 84 a.a.

Genomic Context

MSIL_RS09555MSIL_RS09575MSIL_RS09525MSIL_RS09530MSIL_RS09535MSIL_RS09540MSIL_RS09545MSIL_RS09550MSIL_RS09560MSIL_RS09565MSIL_RS09570MSIL_RS09580MSIL_RS09585
Location: 2037406..2037849 (444 bp)
Type: Others
Protein ID: WP_012590890.1
Location: 2039805..2040014 (210 bp)
Type: Others
Protein ID: WP_012590894.1
Location: 2032940..2033854 (915 bp)
Type: Others
Protein ID: WP_012590884.1
Location: 2034090..2034752 (663 bp)
Type: Others
Protein ID: WP_012590885.1
Location: 2034749..2035465 (717 bp)
Type: Others
Protein ID: WP_012590886.1
Location: 2035764..2036243 (480 bp)
Type: Others
Protein ID: WP_012590887.1
Location: 2036246..2036716 (471 bp)
Type: Others
Protein ID: WP_012590888.1
Location: 2036907..2037335 (429 bp)
Type: Others
Protein ID: WP_012590889.1
Location: 2037854..2038255 (402 bp)
Type: Toxin
Protein ID: WP_187148719.1
Location: 2038252..2038503 (252 bp)
Type: Antitoxin
Protein ID: WP_041367834.1
Location: 2038546..2039625 (1080 bp)
Type: Others
Protein ID: WP_012590893.1
Location: 2040018..2041451 (1434 bp)
Type: Others
Protein ID: WP_012590895.1
Location: 2041540..2042496 (957 bp)
Type: Others
Protein ID: WP_012590896.1
ToxinAntitoxinOther genes
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Locus tag
Coordinates
Strand
Size (bp)
Protein ID
Product
Description
MSIL_RS095252032940..2033854-915WP_012590884.1N-acetyl-gamma-glutamyl-phosphate reductase-
MSIL_RS095302034090..2034752-663WP_012590885.1CerR family C-terminal domain-containing protein-
MSIL_RS095352034749..2035465-717WP_012590886.1hypothetical protein-
MSIL_RS095402035764..2036243-480WP_012590887.130S ribosomal protein S9-
MSIL_RS095452036246..2036716-471WP_012590888.150S ribosomal protein L13-
MSIL_RS095502036907..2037335-429WP_012590889.1cupin domain-containing protein-
MSIL_RS095552037406..2037849+444WP_012590890.1CoA-binding protein-
MSIL_RS095602037854..2038255-402WP_187148719.1type II toxin-antitoxin system VapC family toxinToxin
MSIL_RS095652038252..2038503-252WP_041367834.1AbrB/MazE/SpoVT family DNA-binding domain-containing proteinAntitoxin
MSIL_RS095702038546..2039625-1080WP_012590893.1COX15/CtaA family protein-
MSIL_RS095752039805..2040014+210WP_012590894.1DUF2842 domain-containing protein-
MSIL_RS095802040018..2041451-1434WP_012590895.1LPS biosynthesis protein-
MSIL_RS095852041540..2042496-957WP_012590896.1bifunctional methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase FolD-

Associated MGEs

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MGE
detail
Similar
MGEs
Relative
position
MGE Type
Cargo ARG
Virulence gene
Coordinates
Length (bp)
No matching records found


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(4-123)

Antitoxin

SpoVT-AbrB domain

(15-55)


Sequences

Toxin        


Download         Length: 134 a.a.        Molecular weight: 14354.60 Da        Isoelectric Point: 6.9548

>T23282 WP_187148719.1 NC_011666:c2038255-2037854 [Methylocella silvestris BL2]
MTRYMLDTNILSDLIKNPRGRAAARIEKVGEGDICTSIIVAAELRYGCAKKGSPRLRKVVEDILGEMTVLAFDAPADVEY
GRLRAELEAAGLTIGGNDLLIASHARAVGATIVTANLQEFTRVNGLKVENWLA

Download         Length: 402 bp

>T23282 NC_011666:c2038255-2037854 [Methylocella silvestris BL2]
TTGACGCGCTATATGCTCGACACGAACATCCTTTCCGACCTGATCAAGAATCCGCGCGGCCGGGCGGCGGCGCGGATCGA
GAAAGTCGGCGAGGGCGACATCTGCACCAGCATCATCGTTGCTGCGGAACTGCGCTATGGATGCGCCAAAAAGGGATCTC
CACGCCTCAGGAAAGTGGTGGAAGACATCCTTGGAGAAATGACGGTGCTCGCGTTCGACGCTCCGGCCGACGTCGAATAT
GGCAGGCTCCGCGCGGAGCTTGAGGCGGCGGGTCTGACCATCGGCGGCAACGATCTGCTGATCGCATCGCACGCCCGCGC
GGTAGGAGCGACGATCGTCACCGCGAATCTGCAGGAGTTTACCCGCGTCAATGGCCTGAAGGTCGAGAATTGGCTCGCTT
AG

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9456.91 Da        Isoelectric Point: 4.5348

>AT23282 WP_041367834.1 NC_011666:c2038503-2038252 [Methylocella silvestris BL2]
MLEVSVSEQRRVKLFRNGRNQAVRIPVEFELPGDEAIMSRDGDRLVIEPTRKRGLLALLATLEPLEEALCQIEDRPVAPE
DIF

Download         Length: 252 bp

>AT23282 NC_011666:c2038503-2038252 [Methylocella silvestris BL2]
ATGCTGGAGGTGTCCGTGTCAGAGCAAAGACGCGTCAAGCTGTTCAGAAATGGCCGCAATCAGGCCGTCCGCATTCCCGT
CGAATTTGAATTGCCCGGCGATGAGGCGATCATGAGCCGGGACGGCGACCGGCTGGTCATTGAGCCAACGCGCAAACGCG
GCTTGCTGGCGCTACTCGCAACGCTCGAGCCGCTCGAGGAGGCGCTTTGCCAGATCGAGGATCGGCCGGTCGCGCCTGAA
GACATATTTTGA

Similar Proteins

Only experimentally validated proteins are listed.

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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found
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Protein
Organism
Identities (%)
Coverage (%)
Ha-value
No matching records found

Structures

Toxin

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Source
ID
Structure
No matching records found

Antitoxin

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Source
ID
Structure
No matching records found

References