Detailed information of TA system TA232818

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 3544269..3544925
• Replicon: chromosome
• Accession: NZ_CP091125
• Organism: Serratia marcescens strain CM2015_854

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: A0A5C7DE55
• Locus tag: L2D47_RS17305
• Protein ID: WP_047730091.1
• Coordinates: 3544269..3544658 (-)
• Length: 130 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A8G2LCA8
• Locus tag: L2D47_RS17310
• Protein ID: WP_004941563.1
• Coordinates: 3544662..3544925 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2D47_RS17290 (L2D47_17285)	3540738..3542168	+	1431	WP_047730094.1	MFS transporter	-
L2D47_RS17295 (L2D47_17290)	3542165..3543538	+	1374	WP_055312308.1	two-component system sensor histidine kinase BaeS	-
L2D47_RS17300 (L2D47_17295)	3543548..3544264	+	717	WP_047730092.1	two-component system response regulator BaeR	-
L2D47_RS17305 (L2D47_17300)	3544269..3544658	-	390	WP_047730091.1	type II toxin-antitoxin system VapC family toxin	Toxin
L2D47_RS17310 (L2D47_17305)	3544662..3544925	-	264	WP_004941563.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
L2D47_RS17315 (L2D47_17310)	3545264..3545602	+	339	WP_038873760.1	YegP family protein	-
L2D47_RS17320 (L2D47_17315)	3545904..3547256	+	1353	WP_038873761.1	tRNA 5-hydroxyuridine modification protein YegQ	-
L2D47_RS17325 (L2D47_17320)	3547724..3548629	+	906	WP_038873764.1	lipid kinase YegS	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (2-119)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 130 a.a.
• Molecular weight: 14337.57 Da
• Isoelectric Point: 7.8794

>T232818 WP_047730091.1 NZ_CP091125:c3544658-3544269 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Nucleotide

• Length: 390 bp

>T232818 NZ_CP128255:c4975901-4975590 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGAACGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTCTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 10062.31 Da
• Isoelectric Point: 4.6702

>AT232818 WP_004941563.1 NZ_CP091125:c3544925-3544662 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Nucleotide

• Length: 264 bp

>AT232818 NZ_CP128255:c4975589-4975299 [Escherichia coli]
ATGGATAAGGCACTTTTTGAGCGGTTGACTCACAGCATGGCCCAGATGAATGAAATTATTGAAGGAACGCGACAGCCTTC
ACGGACTTTTGAAGTTGATGCTATGAAAATCAAAGAAATACGCCGCGCTTCAGGGTTGTCACAATCTAAATTTGCCGATC
TTATTTCCGTAAGCGTAGACACGTTGCGTAACTGGGAGCAGGGGCGACGTTCACCGACCGGGCCTGCAAAGGCTTTGCTG
CGAGCGATTGCCAATGATCCGCAACATGTGCTGCAAGCACTTAACCGTTAG

Structures

Toxin

• AlphaFold DB: A0A5C7DE55