Detailed information of TA system TA232817

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 2798143..2798774
• Replicon: chromosome
• Accession: NZ_CP091125
• Organism: Serratia marcescens strain CM2015_854

Toxin (Protein)

• Gene name: vapC
• Uniprot ID: -
• Locus tag: L2D47_RS13895
• Protein ID: WP_055313518.1
• Coordinates: 2798143..2798541 (-)
• Length: 133 a.a.

Antitoxin (Protein)

• Gene name: vapB
• Uniprot ID: A0A0G3SVC2
• Locus tag: L2D47_RS13900
• Protein ID: WP_047730457.1
• Coordinates: 2798541..2798774 (-)
• Length: 78 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2D47_RS13875 (L2D47_13870)	2793246..2794061	-	816	WP_055313115.1	5'-nucleotidase, lipoprotein e(P4) family	-
L2D47_RS13880 (L2D47_13875)	2794390..2794794	-	405	WP_055315478.1	flagellar protein FlhE	-
L2D47_RS13885 (L2D47_13880)	2794794..2796872	-	2079	WP_038876828.1	flagellar biosynthesis protein FlhA	-
L2D47_RS13890 (L2D47_13885)	2796865..2798016	-	1152	WP_047730459.1	flagellar biosynthesis protein FlhB	-
L2D47_RS13895 (L2D47_13890)	2798143..2798541	-	399	WP_055313518.1	type II toxin-antitoxin system VapC family toxin	Toxin
L2D47_RS13900 (L2D47_13895)	2798541..2798774	-	234	WP_047730457.1	type II toxin-antitoxin system VapB family antitoxin	Antitoxin
L2D47_RS13905 (L2D47_13900)	2798900..2799544	-	645	WP_004934858.1	protein phosphatase CheZ	-
L2D47_RS13910 (L2D47_13905)	2799555..2799944	-	390	WP_004934862.1	chemotaxis response regulator CheY	-
L2D47_RS13915 (L2D47_13910)	2800047..2801096	-	1050	WP_015378262.1	chemotaxis response regulator protein-glutamate methylesterase	-
L2D47_RS13920 (L2D47_13915)	2801096..2801968	-	873	WP_025159837.1	protein-glutamate O-methyltransferase CheR	-
L2D47_RS13925 (L2D47_13920)	2802006..2803622	-	1617	WP_240285108.1	methyl-accepting chemotaxis protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (5-124)

Antitoxin

• SpoVT-AbrB domain (7-45)

Sequences

Toxin

Protein

• Length: 133 a.a.
• Molecular weight: 14932.09 Da
• Isoelectric Point: 7.4664

>T232817 WP_055313518.1 NZ_CP091125:c2798541-2798143 [Serratia marcescens]
MFSHMLDTNIVIYVIKRRPLEVLEAFNRYAGKMVISSITYGELVHGVENSARPAVNARVVEDFVSRLDILDYSAKAASHY
GNIRAVLERQGTPIGVNDLHIAGHARSEGLILVTNNRREFERVEGLRLENWL

Nucleotide

• Length: 399 bp

>T232817 NZ_CP128255:c4638850-4638677 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTTCTGGTCGGAATAACCTGGCCAATGAGTCTTCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 78 a.a.
• Molecular weight: 8841.85 Da
• Isoelectric Point: 4.7815

>AT232817 WP_047730457.1 NZ_CP091125:c2798774-2798541 [Serratia marcescens]
MALGSVFTNNRTQAVRLPAEVRFPDTVSKVTVRVVGKERILAPLENTWDSFFCAENEVSDDFLNERAGQHQREREDF

Nucleotide

• Length: 234 bp

>AT232817 NZ_CP128255:c4639174-4638878 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTGATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAACTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTCAAATGCTTAGACTTACCGGATATT
GATTTTGACCTCAGCATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Antitoxin

• AlphaFold DB: A0A0G3SVC2