Detailed information of TA system TA232807

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): parDE/ParE-YefM
• Location: 1015950..1016517
• Replicon: chromosome
• Accession: NZ_CP091125
• Organism: Serratia marcescens strain CM2015_854

Toxin (Protein)

• Gene name: parE
• Uniprot ID: -
• Locus tag: L2D47_RS05055
• Protein ID: WP_028127915.1
• Coordinates: 1015950..1016255 (-)
• Length: 102 a.a.

Antitoxin (Protein)

• Gene name: parD
• Uniprot ID: A0A8B4G8D1
• Locus tag: L2D47_RS05060
• Protein ID: WP_016928576.1
• Coordinates: 1016257..1016517 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2D47_RS05020 (L2D47_05020)	1011598..1012674	+	1077	WP_016928582.1	urea ABC transporter permease subunit UrtC	-
L2D47_RS05025 (L2D47_05025)	1012671..1013477	+	807	WP_033637599.1	urea ABC transporter ATP-binding protein UrtD	-
L2D47_RS05030 (L2D47_05030)	1013490..1014188	+	699	WP_038880102.1	urea ABC transporter ATP-binding subunit UrtE	-
L2D47_RS05035 (L2D47_05035)	1014196..1014495	-	300	WP_042783942.1	type II toxin-antitoxin system RelE/ParE family toxin	-
L2D47_RS05040 (L2D47_05040)	1014480..1014743	-	264	WP_004939442.1	type II toxin-antitoxin system ParD family antitoxin	-
L2D47_RS05045 (L2D47_05045)	1014878..1015390	+	513	WP_055313317.1	DUF2165 family protein	-
L2D47_RS05050 (L2D47_05050)	1015413..1015925	-	513	WP_055315535.1	GNAT family N-acetyltransferase	-
L2D47_RS05055 (L2D47_05055)	1015950..1016255	-	306	WP_028127915.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
L2D47_RS05060 (L2D47_05060)	1016257..1016517	-	261	WP_016928576.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
L2D47_RS05065 (L2D47_05065)	1016586..1017821	-	1236	WP_055312494.1	FAD-dependent oxidoreductase	-
L2D47_RS05070 (L2D47_05070)	1018102..1018977	+	876	WP_055312495.1	LysR substrate-binding domain-containing protein	-
L2D47_RS05075 (L2D47_05075)	1018967..1019812	-	846	WP_038880118.1	3-mercaptopyruvate sulfurtransferase	-
L2D47_RS05080 (L2D47_05080)	1019919..1020341	+	423	WP_055312496.1	NUDIX hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-92)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (3-65)

Sequences

Toxin

Protein

• Length: 102 a.a.
• Molecular weight: 11954.71 Da
• Isoelectric Point: 9.5902

>T232807 WP_028127915.1 NZ_CP091125:c1016255-1015950 [Serratia marcescens]
MPAFRLTPQAQQDLLAIRHFTIEHWGQAQSRRYLEQLREVMHHLADMPEAGKAHFHDLGEEIRSFPYASHRIYYRNRPAG
ITVLAILHQAMVPHRHLEQRL

Nucleotide

• Length: 306 bp

>T232807 NZ_CP128255:1996688-1996939 [Escherichia coli]
ATGCGTACAATTAGCTACAGCGAAGCGTGTCAGAATTTGTCGGCAACAATGATGAAAGCCGTTGAAGATCATGCCCCGAT
CCTCATTACTCGTCAGAATGGAGAGGCTTGTGTTCTGATGTCACTCGAAGAATACAACTCGCTGGAAGAGACGGCTTATC
TACTGCGTTCCCCCGCTAACGCCCGGAGATTGATGGACTCAATCGATAGCCTGAAATCAGGCAAAGGAACGGAAAAGGAC
ATTATTGAGTGA

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 9442.59 Da
• Isoelectric Point: 4.1964

>AT232807 WP_016928576.1 NZ_CP091125:c1016517-1016257 [Serratia marcescens]
MYALTANEAKTQFGDLLLKAQREPVQINRNGKPVAVVMSVEDYQALEDLKLSALQQKIAQATAEEDAGKAVDGDAFFNRL
LTDETD

Nucleotide

• Length: 261 bp

>AT232807 NZ_CP128255:1996936-1997190 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAACTTATCAAAGATACCCGCAGAACACCATTTGAAGGTAAGGGGAAACCAGAACCCCTGAAACATAATTTGTCAG
GTTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACTGATGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Structures

Antitoxin

• AlphaFold DB: A0A8B4G8D1