Detailed information of TA system TA232805

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/RelE(toxin)
• Location: 181199..181671
• Replicon: chromosome
• Accession: NZ_CP091125
• Organism: Serratia marcescens strain CM2015_854

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A5P6GNV0
• Locus tag: L2D47_RS00845
• Protein ID: WP_048232401.1
• Coordinates: 181396..181671 (+)
• Length: 92 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: -
• Locus tag: L2D47_RS00840
• Protein ID: WP_033649649.1
• Coordinates: 181199..181396 (+)
• Length: 66 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2D47_RS00810 (L2D47_00810)	176382..177650	+	1269	WP_055313077.1	glycerol-3-phosphate dehydrogenase subunit GlpB	-
L2D47_RS00815 (L2D47_00815)	177647..178846	+	1200	WP_055313079.1	anaerobic glycerol-3-phosphate dehydrogenase subunit GlpC	-
L2D47_RS00820 (L2D47_00820)	178882..179445	-	564	WP_047729417.1	DcrB family lipoprotein	-
L2D47_RS00825 (L2D47_00825)	179526..179960	-	435	WP_048232398.1	GNAT family N-acetyltransferase	-
L2D47_RS00830 (L2D47_00830)	180012..180671	-	660	WP_047729415.1	7-cyano-7-deazaguanine/7-aminomethyl-7- deazaguanine transporter	-
L2D47_RS00835 (L2D47_00835)	180892..181137	+	246	WP_025304890.1	sulfurtransferase TusA	-
L2D47_RS00840 (L2D47_00840)	181199..181396	+	198	WP_033649649.1	hypothetical protein	Antitoxin
L2D47_RS00845 (L2D47_00845)	181396..181671	+	276	WP_048232401.1	type II toxin-antitoxin system mRNA interferase toxin, RelE/StbE family	Toxin
L2D47_RS00850 (L2D47_00850)	181731..184049	-	2319	WP_048232403.1	zinc/cadmium/mercury/lead-transporting ATPase	-
L2D47_RS00855 (L2D47_00855)	184732..186195	+	1464	WP_038874135.1	serralysin family metalloprotease	-
L2D47_RS00860 (L2D47_00860)	186251..186628	+	378	WP_038874139.1	AprI/Inh family metalloprotease inhibitor	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-90)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10666.57 Da
• Isoelectric Point: 11.2806

>T232805 WP_048232401.1 NZ_CP091125:181396-181671 [Serratia marcescens]
MLNIEWTRVARQDLGEIVGFIANDNPLAARKMKALIMEAVIPAARHPRIFRRGRVDGTHEIPLHPHYLLVYQVLETHIRV
LRVLHTRRQYP

Nucleotide

• Length: 276 bp

>T232805 NZ_CP128255:994606-995013 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCGCTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGCATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCGCCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGACAGCGGAAAACGGCA
ACATTTATGGCTGGCAGCTGACAGCATGGACGAAGCCGAATGGCGGGATTTACGGCGGATATTGTTACAACAAGAGACGC
AAAGATAA

Antitoxin

Protein

• Length: 66 a.a.
• Molecular weight: 7398.49 Da
• Isoelectric Point: 4.4143

>AT232805 WP_033649649.1 NZ_CP091125:181199-181396 [Serratia marcescens]
MSILLLPTVAKMENEERTQGYERWFLERVQEAMDEPRPGIPHDDVMAEMDAVIAAAEARIKAKQA

Nucleotide

• Length: 198 bp

>AT232805 NZ_CP128255:994359-994625 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATTCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Structures

Toxin

• AlphaFold DB: A0A5P6GNV0