Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE(toxin)
Location 4373879..4374351 Replicon chromosome
Accession NZ_CP091123
Organism Serratia marcescens strain CM2017_569

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L2D48_RS20850 Protein ID WP_064291161.1
Coordinates 4373879..4374154 (-) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L2D48_RS20855 Protein ID WP_240296056.1
Coordinates 4374160..4374351 (-) Length 64 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D48_RS20825 (L2D48_20825) 4369199..4370479 - 1281 WP_048234658.1 polysaccharide deacetylase family protein -
L2D48_RS20830 (L2D48_20830) 4370657..4371427 - 771 WP_004937535.1 ABC transporter permease -
L2D48_RS20835 (L2D48_20835) 4371424..4372347 - 924 WP_038872436.1 ABC transporter ATP-binding protein -
L2D48_RS20840 (L2D48_20840) 4372558..4373214 + 657 WP_049200096.1 carbonate dehydratase -
L2D48_RS20845 (L2D48_20845) 4373252..4373788 - 537 WP_048234659.1 hypoxanthine phosphoribosyltransferase -
L2D48_RS20850 (L2D48_20850) 4373879..4374154 - 276 WP_064291161.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2D48_RS20855 (L2D48_20855) 4374160..4374351 - 192 WP_240296056.1 stability determinant Antitoxin
L2D48_RS20860 (L2D48_20860) 4374457..4376109 - 1653 WP_240296057.1 multicopper oxidase CueO -
L2D48_RS20865 (L2D48_20865) 4376328..4376675 + 348 WP_004937515.1 YacC family pilotin-like protein -
L2D48_RS20870 (L2D48_20870) 4376800..4377663 + 864 WP_102985227.1 polyamine aminopropyltransferase -
L2D48_RS20875 (L2D48_20875) 4377691..4378485 + 795 WP_049200100.1 adenosylmethionine decarboxylase -
L2D48_RS20880 (L2D48_20880) 4378518..4378880 - 363 WP_004937507.1 protein YacL -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(4-90)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10352.05 Da        Isoelectric Point: 6.8785

>T232802 WP_064291161.1 NZ_CP091123:c4374154-4373879 [Serratia marcescens]
MLTVKWTDEAKTGLYTLLAFIAERNPLAAEALLQRIEESVIPLAEHPYLFRPGRVNGTREMVVHPNYIVVYRVLAAHIEI
AGVLHARQEYP

Download         Length: 276 bp

>T232802 NZ_CP128255:195488-195595 [Escherichia coli]
ATGACGCTCGCAGAACTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAATAAGCGGAAGTAA

Antitoxin


Download         Length: 64 a.a.        Molecular weight: 7217.03 Da        Isoelectric Point: 6.4623

>AT232802 WP_240296056.1 NZ_CP091123:c4374351-4374160 [Serratia marcescens]
MPTKLDPIVSEFETQEQADSYDRWFRSTVESSINSDSPRIPHDEVMAGARHIIERAKAKRKSA

Download         Length: 192 bp

>AT232802 NZ_CP128255:c195431-195373 [Escherichia coli]
TCAAGATTAGCCCCCGTGATGTTGTCAGGTGCATACCTGCAACGTGCGGGGGTTTTCTC

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References