Detailed information of TA system TA232801

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 4252615..4253284
• Replicon: chromosome
• Accession: NZ_CP091123
• Organism: Serratia marcescens strain CM2017_569

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: -
• Locus tag: L2D48_RS20290
• Protein ID: WP_048234633.1
• Coordinates: 4252615..4253037 (-)
• Length: 141 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: A0A8B4GS04
• Locus tag: L2D48_RS20295
• Protein ID: WP_019455657.1
• Coordinates: 4253018..4253284 (-)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L2D48_RS20270 (L2D48_20270)	4248548..4250281	-	1734	WP_038871239.1	single-stranded-DNA-specific exonuclease RecJ	-
L2D48_RS20275 (L2D48_20275)	4250288..4251004	-	717	WP_038871236.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
L2D48_RS20280 (L2D48_20280)	4251031..4251930	-	900	WP_038871248.1	site-specific tyrosine recombinase XerD	-
L2D48_RS20285 (L2D48_20285)	4252037..4252555	+	519	WP_038871234.1	flavodoxin FldB	-
L2D48_RS20290 (L2D48_20290)	4252615..4253037	-	423	WP_048234633.1	protein YgfX	Toxin
L2D48_RS20295 (L2D48_20295)	4253018..4253284	-	267	WP_019455657.1	FAD assembly factor SdhE	Antitoxin
L2D48_RS20300 (L2D48_20300)	4253605..4254597	+	993	WP_047729922.1	tRNA-modifying protein YgfZ	-
L2D48_RS20305 (L2D48_20305)	4254636..4255133	-	498	WP_038871226.1	DUF2165 domain-containing protein	-
L2D48_RS20310 (L2D48_20310)	4255284..4255958	-	675	WP_038871224.1	hemolysin III family protein	-
L2D48_RS20315 (L2D48_20315)	4256142..4256750	+	609	WP_240296044.1	HD domain-containing protein	-
L2D48_RS20320 (L2D48_20320)	4256783..4257709	-	927	WP_048234635.1	ribokinase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (2-131)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 141 a.a.
• Molecular weight: 16528.58 Da
• Isoelectric Point: 10.8114

>T232801 WP_048234633.1 NZ_CP091123:c4253037-4252615 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPTEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPTGDGEPE

Nucleotide

• Length: 423 bp

>T232801 NZ_CP128233:3083147-3083557 [Paralcaligenes sp. CC-YST667]
ATGCTCAAATTCATGCTCGACACCAATATCTGCATTTTCACCATCAAGAATCGGCCGCAAGAAGTTCGGGAAGCGTTCAA
GCGGCACTCTGGCCAAATGTGCATCAGCACGGTAACGCTGATGGAACTCATCTATGGTGCCGAGAAATCTTCGAATCCCG
AGCGTAATCTGGCAGACGTTGAAGCTTTCGCTGCGCGCCTTGACGTACTCAACTATGATGCGCAAGCGGCCGCACATACC
GGTCAGCTTCGCGCAGAGCTTGCCCGTGTTGGCCAGCAGATTGGTCCCTATGACCAAATGATCGCAGGCCATGCCCGATC
GAACGGGCTTATTGTGGTGACTAACAACCGCCGCGAGTTCGACCGGGTACCCGGTTTAAGAATTGAAGATTGGGTTGCCC
AGGCGGGATGA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10417.91 Da
• Isoelectric Point: 4.7921

>AT232801 WP_019455657.1 NZ_CP091123:c4253284-4253018 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDSELQRMVTLIQTRN
KDRGPVAM

Nucleotide

• Length: 267 bp

>AT232801 NZ_CP128233:3082917-3083147 [Paralcaligenes sp. CC-YST667]
ATGGAACAAGGTGCTGTTTTTCAAAGCAATCGCAGTCAGGCCATCAGGCTGCCCAAAGCCGTCGCGCTGCCTGACGATGT
CAAACGGGTTGACGTGGTGGCGCTGGGCCGAACCCGAATCATCACACCGGCCGGTGAATCATGGGATAGCTGGTTCGACG
CCGTGGGTGTAACGCCTGATTTCATGGCACAGCGCGAGCAGCCGGATGCCCAAGAGCGCGAGGCGTTTTAA

Structures

Antitoxin

• AlphaFold DB: A0A8B4GS04