Detailed information of TA system TA023280

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): /ElaA(toxin)
• Location: 77780..78629
• Replicon: plasmid pS22301
• Accession: NC_011664
• Organism: Shewanella baltica OS223

Toxin (Protein)

• Gene name: -
• Uniprot ID: B8EFS1
• Locus tag: SBAL223_RS22460
• Protein ID: WP_011979514.1
• Coordinates: 78120..78629 (-)
• Length: 170 a.a.

Antitoxin (Protein)

• Gene name: hicB
• Uniprot ID: -
• Locus tag: SBAL223_RS22455
• Protein ID: WP_011979515.1
• Coordinates: 77780..78007 (-)
• Length: 76 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL223_RS22435	73022..74377	-	1356	WP_012589006.1	site-specific integrase	-
SBAL223_RS22440	74374..75504	-	1131	WP_012589007.1	site-specific integrase	-
SBAL223_RS22445	75859..76158	-	300	WP_012197944.1	hypothetical protein	-
SBAL223_RS22450	76207..77205	-	999	WP_012589008.1	DUF1738 domain-containing protein	-
SBAL223_RS22455	77780..78007	-	228	WP_011979515.1	hypothetical protein	Antitoxin
SBAL223_RS22460	78120..78629	-	510	WP_011979514.1	GNAT family N-acetyltransferase	Toxin
SBAL223_RS22465	78610..78903	-	294	WP_011979513.1	DUF1778 domain-containing protein	-
SBAL223_RS22470	79273..79674	-	402	WP_011979512.1	hypothetical protein	-
SBAL223_RS22475	79676..80299	-	624	WP_012589009.1	hypothetical protein	-
SBAL223_RS22480	80975..81196	-	222	WP_011979510.1	hypothetical protein	-
SBAL223_RS22485	81227..81715	-	489	WP_011979509.1	hypothetical protein	-
SBAL223_RS22490	81717..82172	-	456	WP_011979508.1	type II toxin-antitoxin system HicB family antitoxin	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	stcE	1..88311	88311

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• GNAT domain (80-143)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 170 a.a.
• Molecular weight: 19129.15 Da
• Isoelectric Point: 8.3399

>T23280 WP_011979514.1 NC_011664:c78629-78120 [Shewanella baltica OS223]
MKITQFDKNEHDRKSFDCGNTELNNYLKCISGQHEKKDISRTYVLTSELNPSHIKGYYSIAVAQVSLCELPTEIAKKYPS
EITCSLIGRMAVNHTCQRQGLGSILLIDAIKRIIQASSAIPIPMIIVQAKNEDARRFYSEFGFVSFPDNYLKLMMTLAHA
KAMLKEAEH

Nucleotide

• Length: 510 bp

>T23280 NC_011664:c78629-78120 [Shewanella baltica OS223]
ATGAAAATTACCCAATTTGATAAAAATGAGCATGACCGTAAGAGTTTTGATTGTGGGAATACAGAGCTAAACAATTACCT
GAAATGCATTTCAGGTCAGCATGAAAAGAAAGATATTTCAAGAACATATGTTCTTACTTCAGAGTTAAATCCTTCACACA
TAAAAGGTTATTACTCTATTGCGGTAGCTCAGGTATCACTTTGTGAGTTACCAACCGAAATAGCTAAAAAATATCCATCT
GAAATAACGTGTAGCTTGATAGGTCGAATGGCTGTTAACCATACCTGTCAAAGACAAGGGCTTGGCTCAATATTGCTTAT
AGACGCAATCAAACGAATTATCCAAGCTTCCAGTGCTATCCCCATCCCTATGATTATTGTTCAAGCAAAGAACGAAGATG
CTAGACGTTTTTATAGTGAGTTTGGTTTTGTATCCTTTCCTGATAATTATTTGAAACTCATGATGACACTGGCCCATGCT
AAAGCGATGTTGAAAGAAGCCGAACATTAA

Antitoxin

Protein

• Length: 76 a.a.
• Molecular weight: 8335.43 Da
• Isoelectric Point: 3.8074

>AT23280 WP_011979515.1 NC_011664:c78007-77780 [Shewanella baltica OS223]
MMQNAMTFKGYHGSVEISPEDNILFGQVLFISPLINYEAETAKELEQAFQEAINAYLADCVQQDIPPEKALEGIA

Nucleotide

• Length: 228 bp

>AT23280 NC_011664:c78007-77780 [Shewanella baltica OS223]
ATGATGCAAAATGCAATGACATTTAAGGGTTATCACGGCTCTGTAGAAATCAGCCCAGAGGATAATATTCTGTTTGGGCA
GGTGTTATTCATTTCACCGTTGATCAACTATGAGGCCGAAACCGCCAAAGAGTTAGAGCAAGCATTTCAAGAGGCGATTA
ACGCTTATCTTGCTGATTGTGTTCAACAGGACATTCCGCCAGAGAAAGCCTTGGAAGGGATAGCTTAA

Structures

Toxin

• AlphaFold DB: A9L6I1