Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3920623..3921279 Replicon chromosome
Accession NZ_CP091123
Organism Serratia marcescens strain CM2017_569

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2D48_RS18715 Protein ID WP_038873757.1
Coordinates 3920623..3921012 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag L2D48_RS18720 Protein ID WP_004941563.1
Coordinates 3921016..3921279 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D48_RS18700 (L2D48_18700) 3917092..3918522 + 1431 WP_038873750.1 multidrug transporter subunit MdtD -
L2D48_RS18705 (L2D48_18705) 3918519..3919892 + 1374 WP_038873752.1 two-component system sensor histidine kinase BaeS -
L2D48_RS18710 (L2D48_18710) 3919902..3920618 + 717 WP_038873754.1 two-component system response regulator BaeR -
L2D48_RS18715 (L2D48_18715) 3920623..3921012 - 390 WP_038873757.1 type II toxin-antitoxin system VapC family toxin Toxin
L2D48_RS18720 (L2D48_18720) 3921016..3921279 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L2D48_RS18725 (L2D48_18725) 3921618..3921956 + 339 WP_038873760.1 YegP family protein -
L2D48_RS18730 (L2D48_18730) 3922258..3923610 + 1353 WP_038873761.1 tRNA 5-hydroxyuridine modification protein YegQ -
L2D48_RS18735 (L2D48_18735) 3924078..3924983 + 906 WP_038873764.1 lipid kinase YegS -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14318.53 Da        Isoelectric Point: 7.3214

>T232799 WP_038873757.1 NZ_CP091123:c3921012-3920623 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RANMERKGKIMGALDQLIAAHAQSHGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T232799 NZ_CP128233:c2748309-2748061 [Paralcaligenes sp. CC-YST667]
ATGCAAACTTGGCAGATGCAAGAAGCGAAGGCGCGAATGTCGGAAGTGGTCAAGCGCGCACAAGACCAACCCCAAGACAT
CACCCTGCATGGAAAATCGGTGGCCGTCGTGATTTCGCGCGAGACCTTTGATCGCTTGTCGCAGTCACAAGGCTCGCTGG
TTGATTTCATGCGGCGCTCGCCGCTCTATGAAGCGAACGACATTGCATTTGAGCGCGACCGCAGCCTGACCCGGGAGGTG
GCTTTTTGA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT232799 WP_004941563.1 NZ_CP091123:c3921279-3921016 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT232799 NZ_CP128233:c2748064-2747651 [Paralcaligenes sp. CC-YST667]
TTGAGCTACCTGATCGACACCAACGTGCTGTCTGAATTGCGCCGCAAGGCACCCGACCCCGGCGTTGTCGCCTGGTTCTC
GCAGCGACCAGCGTCCACCCTGCACCTGTCAGTGCTGACGTTGGGTGAAATCCGCAAAGACGTTGAAGGCGTCAGCGATG
AAGCGCGCCGCCAGACATTACTTGATTGGCTGGAGACGGACTTGCCAACCTTCTTTACCGGCCGTGTGCTGCCGGTCGAT
GCCGCCGTGGCTGATCGCTGGGGACGTTTGGTCGCCACAGCGGGTCGGCCTCTCCCCGCCATCGATAGCTTGCTGGCCGC
CACCGCACTGGAACACGATCTGGTATTGGTCACACGCAACGCCAAGGATTTCGCAGGTCTGCCCATCGATATCTTCAACC
CTTGGTCAAACTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References