Detailed information of TA system TA023279

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 1566..2082
• Replicon: plasmid pS22301
• Accession: NC_011664
• Organism: Shewanella baltica OS223

Toxin (Protein)

• Gene name: relE
• Uniprot ID: B8EFR1
• Locus tag: SBAL223_RS22125
• Protein ID: WP_011979492.1
• Coordinates: 1798..2082 (+)
• Length: 95 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: B8EFR0
• Locus tag: SBAL223_RS22120
• Protein ID: WP_011979491.1
• Coordinates: 1566..1808 (+)
• Length: 81 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL223_RS22110	254..874	+	621	WP_011979489.1	DUF2913 family protein	-
SBAL223_RS22115	967..1239	+	273	WP_011979490.1	hypothetical protein	-
SBAL223_RS22120	1566..1808	+	243	WP_011979491.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
SBAL223_RS22125	1798..2082	+	285	WP_011979492.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
SBAL223_RS22130	2281..3204	+	924	WP_011979493.1	IS5 family transposase	-
SBAL223_RS22135	3408..4436	+	1029	WP_011979494.1	IS110 family transposase	-
SBAL223_RS22150	5896..6935	-	1040	Protein_7	IS3 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Non-Mobilizable plasmid	-	stcE	1..88311	88311

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (4-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-69)

Sequences

Toxin

Protein

• Length: 95 a.a.
• Molecular weight: 11079.11 Da
• Isoelectric Point: 10.5812

>T23279 WP_011979492.1 NC_011664:1798-2082 [Shewanella baltica OS223]
MIYKLVFDPRALKEWNKLGDPIRQQLKKKLAEILQHPHIGANKLRDLPDCYKIKLRTSGYRLVYQVQDERITVFVVAVGK
RERLAVYSTAEKRL

Nucleotide

• Length: 285 bp

>T23279 NC_011664:1798-2082 [Shewanella baltica OS223]
ATGATCTATAAGTTAGTATTTGATCCCCGCGCATTAAAGGAATGGAACAAGCTTGGAGATCCCATCAGGCAGCAGTTAAA
AAAGAAACTGGCCGAGATACTGCAACATCCTCATATCGGGGCTAACAAACTTAGAGATCTCCCTGACTGTTACAAAATCA
AGTTGCGTACATCAGGTTATCGCTTGGTATATCAAGTACAAGATGAACGCATTACCGTGTTTGTCGTGGCCGTAGGCAAG
CGTGAACGATTAGCGGTGTATTCAACAGCAGAAAAGCGCCTTTAA

Antitoxin

Protein

• Length: 81 a.a.
• Molecular weight: 8816.24 Da
• Isoelectric Point: 4.4501

>AT23279 WP_011979491.1 NC_011664:1566-1808 [Shewanella baltica OS223]
MGTINIRIDDELKERSFAVLEKLGVSPSEALRQMLEYVATSGAMPFKPVLLTAEDEALISLVKERLASPRKGIEVSLDDL

Nucleotide

• Length: 243 bp

>AT23279 NC_011664:1566-1808 [Shewanella baltica OS223]
ATGGGCACTATTAATATTCGCATCGATGACGAGCTTAAGGAGCGTTCTTTTGCTGTGTTGGAAAAATTAGGCGTTAGTCC
CTCTGAGGCATTGCGGCAAATGCTTGAGTATGTCGCCACAAGCGGCGCTATGCCATTTAAACCCGTACTGCTAACAGCAG
AGGATGAAGCCTTGATCTCCTTGGTTAAAGAGCGTTTAGCGAGCCCTCGAAAGGGGATCGAGGTTTCGCTCGATGATCTA
TAA

Structures

Toxin

• AlphaFold DB: A9L6M1

Antitoxin

• AlphaFold DB: A9L6M0