Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RHH(antitoxin)
Location 55894..56429 Replicon chromosome
Accession NZ_CP091123
Organism Serratia marcescens strain CM2017_569

Toxin (Protein)


Gene name relE Uniprot ID A0A854J4R0
Locus tag L2D48_RS00255 Protein ID WP_038875945.1
Coordinates 56154..56429 (+) Length 92 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID A0A5P6GNG1
Locus tag L2D48_RS00250 Protein ID WP_038875948.1
Coordinates 55894..56154 (+) Length 87 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D48_RS00230 (L2D48_00230) 51184..51864 + 681 WP_240296128.1 DUF1795 domain-containing protein -
L2D48_RS00235 (L2D48_00235) 51905..52510 + 606 WP_038875954.1 glutathione S-transferase -
L2D48_RS00240 (L2D48_00240) 52579..53973 + 1395 WP_047729550.1 L-seryl-tRNA(Sec) selenium transferase -
L2D48_RS00245 (L2D48_00245) 53970..55811 + 1842 WP_240296129.1 selenocysteine-specific translation elongation factor -
L2D48_RS00250 (L2D48_00250) 55894..56154 + 261 WP_038875948.1 ribbon-helix-helix domain-containing protein Antitoxin
L2D48_RS00255 (L2D48_00255) 56154..56429 + 276 WP_038875945.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2D48_RS00260 (L2D48_00260) 56441..57352 - 912 WP_038875943.1 LysR family transcriptional regulator -
L2D48_RS00265 (L2D48_00265) 57474..58100 + 627 WP_240296130.1 LysE family translocator -
L2D48_RS00270 (L2D48_00270) 58153..59400 - 1248 WP_038875940.1 MFS transporter -
L2D48_RS00275 (L2D48_00275) 59618..60610 + 993 WP_240296131.1 acyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(3-90)

Antitoxin

Ribbon-helix-helix protein, CopG

(6-43)


Sequences

Toxin        


Download         Length: 92 a.a.        Molecular weight: 10548.34 Da        Isoelectric Point: 10.6099

>T232785 WP_038875945.1 NZ_CP091123:56154-56429 [Serratia marcescens]
MALKWTSKALSDLARLFEFLALANRTVAANSVKALVAAPKALLDNPRLGERLDEFLPQEVRRILVGRYEIRYQVQPATIY
VLRIWHTREER

Download         Length: 276 bp

>T232785 NZ_CP128233:956727-957038 [Paralcaligenes sp. CC-YST667]
ATGGAATTCATCGAAACTCCCCTGTTCACTCGACAAATCGTAGACTTGCTTCCAGACGATGACTACGCTGAACTGCAACA
GATTTTGGCTGCTAACCCTCGGCGGGGTGATCTGATTCCGTCTGGAGGAGGAATCCGAAAGGTACGTCATGCAAGACCAG
GAATGGGGAAAAGTGGCGGCATTCGTGTCATCTACTACTGGATCACTGCCGAAGATCAAATCATGATGCTCCTGGCTTAT
CCGAAGTCGAAACAGGAGAATCTGACCCCCGCACAGATTGAGGAACTGCGGGCATTGGTAAAGGACCTCTGA

Antitoxin


Download         Length: 87 a.a.        Molecular weight: 9667.98 Da        Isoelectric Point: 4.5201

>AT232785 WP_038875948.1 NZ_CP091123:55894-56154 [Serratia marcescens]
MNTKVITAHVPLPLAEKVDEMAAKLERSRGWIVKQALAAWLEQEEERRRLTLAALADVEQQNVIDHESVEAWAASLDSDD
PLPVPR

Download         Length: 261 bp

>AT232785 NZ_CP128233:957040-957327 [Paralcaligenes sp. CC-YST667]
ATGGACACAGAACTCTTTGAAGACCTAAAAGAAAGCCTGCGGCAAGCCAAGGCCATCCGCGCAGGCGAGCTCGAAGGCCG
CCGCACTACCGTCAGCCCCATTGACGTCAGGGCCGTGCGCGAAAGCACGAAGCTCTCGCAAGGCGAGTTTGCTGCAGCCA
TCAACGTCAGCGTGCGTACACTACAGAATTGGGAGCAACACCGGCGATCTCCTACCGGCCCAGCCGCCGCCCTGCTGAAA
GTCATGGCAGCGGCTCCAGCCACCGTCATCAAAGCCCTACATCACTAG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A854J4R0

Antitoxin

Source ID Structure
AlphaFold DB A0A5P6GNG1

References