Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4097170..4097839 Replicon chromosome
Accession NZ_CP091122
Organism Serratia marcescens strain CM2012_028

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag L2D51_RS19600 Protein ID WP_123867884.1
Coordinates 4097170..4097592 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag L2D51_RS19605 Protein ID WP_004931679.1
Coordinates 4097573..4097839 (-) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D51_RS19580 (L2D51_19580) 4093059..4093577 + 519 WP_004931683.1 flavodoxin FldB -
L2D51_RS19585 (L2D51_19585) 4093615..4094979 - 1365 WP_240293690.1 cell envelope integrity protein CreD -
L2D51_RS19590 (L2D51_19590) 4095060..4096478 - 1419 WP_240293691.1 two-component system sensor histidine kinase CreC -
L2D51_RS19595 (L2D51_19595) 4096475..4097170 - 696 WP_123867883.1 two-component system response regulator CreB -
L2D51_RS19600 (L2D51_19600) 4097170..4097592 - 423 WP_123867884.1 protein YgfX Toxin
L2D51_RS19605 (L2D51_19605) 4097573..4097839 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
L2D51_RS19610 (L2D51_19610) 4098160..4099152 + 993 WP_016929977.1 tRNA-modifying protein YgfZ -
L2D51_RS19615 (L2D51_19615) 4099191..4099688 - 498 WP_197759266.1 DUF2165 domain-containing protein -
L2D51_RS19620 (L2D51_19620) 4099839..4100513 - 675 WP_028127690.1 hemolysin III family protein -
L2D51_RS19625 (L2D51_19625) 4100697..4101305 + 609 WP_028127691.1 HD domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(2-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 141 a.a.        Molecular weight: 16527.65 Da        Isoelectric Point: 11.0198

>T232780 WP_123867884.1 NZ_CP091122:c4097592-4097170 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGFGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGMLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGNGEEP

Download         Length: 423 bp

>T232780 NZ_CP091122:c4097592-4097170 [Serratia marcescens]
GTGGCCCAGTGGCGATGTGATATCCGCATTTCCTGGCGCACCCAGCTGTTTTCACTGTTGACCCACGGCGTTCTGATCCT
GCTGATCCTGATTTCGCCCTGGCCGGAGGGCTTTGGCCCGCTCTGGCTGGTGCTGCTGACGCTGGTGGTGTTTCAGTGCA
TTCGCAGCCAGAAGCGCATCGCCGCAGTGCAGGGCGAGCTGCGGCTGCTGGCGGACAGGCGTTTCAGCTGGCACGGCCGC
GAGTGGCGGCTGGCGAAAAAACCGTGGATGCCGGGTTACGGCATGCTGTTGACGCTGCAGCCGATGGAAGGCAAAAAGCG
CCGTCGGCTGTGGCTGGCTTCCGACTGCATGAGCAAAGAGGAGTGGCGCCACCTGCGGCAGCTGTTGCTGTATCCGCCGG
CGGGTAACGGCGAGGAACCCTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT232780 WP_004931679.1 NZ_CP091122:c4097839-4097573 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT232780 NZ_CP091122:c4097839-4097573 [Serratia marcescens]
ATGGATATTAACAACAAAGCACGTATTCACTGGGCTTGCCGTCGTGGCATGCGCGAGCTGGACATCTCCATCATGCCGTT
CTTCGAATACGAATACGACAGCCTGAATGACGCGGACAAGGCGCTGTTTATCCGCCTGCTGGAGTGTGACGATCCCGATT
TGTTCAACTGGCTGATGAATCATGGCGCGCCGCAGGATGGCGAGCTGCAGAGAATGGTGACCCTGATCCAAACGCGAAAT
AAAGACCGTGGCCCAGTGGCGATGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References