Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3748950..3749606 Replicon chromosome
Accession NZ_CP091122
Organism Serratia marcescens strain CM2012_028

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2D51_RS17985 Protein ID WP_016926704.1
Coordinates 3748950..3749339 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag L2D51_RS17990 Protein ID WP_004941563.1
Coordinates 3749343..3749606 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D51_RS17970 (L2D51_17970) 3745418..3746848 + 1431 WP_016926706.1 multidrug transporter subunit MdtD -
L2D51_RS17975 (L2D51_17975) 3746845..3748227 + 1383 WP_016926705.1 two-component system sensor histidine kinase BaeS -
L2D51_RS17980 (L2D51_17980) 3748227..3748943 + 717 WP_004941568.1 two-component system response regulator BaeR -
L2D51_RS17985 (L2D51_17985) 3748950..3749339 - 390 WP_016926704.1 type II toxin-antitoxin system VapC family toxin Toxin
L2D51_RS17990 (L2D51_17990) 3749343..3749606 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L2D51_RS17995 (L2D51_17995) 3749945..3750283 + 339 WP_016926703.1 YegP family protein -
L2D51_RS18000 (L2D51_18000) 3750462..3751814 + 1353 WP_239442424.1 tRNA 5-hydroxyuridine modification protein YegQ -
L2D51_RS18005 (L2D51_18005) 3752281..3753186 + 906 WP_016926701.1 lipid kinase YegS -
L2D51_RS18010 (L2D51_18010) 3753355..3754569 + 1215 WP_016926700.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14342.61 Da        Isoelectric Point: 7.8794

>T232779 WP_016926704.1 NZ_CP091122:c3749339-3748950 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMEKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDSEAARCYGEM
RATMERKGKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T232779 NZ_CP128219:105831-106109 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT232779 WP_004941563.1 NZ_CP091122:c3749606-3749343 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT232779 NZ_CP128219:105568-105828 [Escherichia coli]
ATGGCTGCTAACGCGTTTGTTCGCGCCCGAATCGATGAAGATCTGAAGAATCAGGCAGCGGACGTACTGGCCGGGATGGG
GCTGACCATCTCTGACCTGGTTCGCATAACCCTCACAAAGGTCGCGCGTGAAAAGGCATTGCCGTTTGATTTACGCGAGC
CTAATCAATTAACCATTCAATCAATCAAAAACAGCGAAGCTGGCATTGATGTTCATAAGGCCAAAGACGCCGATGATTTA
TTTGATAAATTAGGAATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References