Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 3663356..3663918 Replicon chromosome
Accession NZ_CP091122
Organism Serratia marcescens strain CM2012_028

Toxin (Protein)


Gene name doc Uniprot ID -
Locus tag L2D51_RS17585 Protein ID WP_239442151.1
Coordinates 3663356..3663712 (-) Length 119 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID A0A8G2G5I1
Locus tag L2D51_RS17590 Protein ID WP_004936539.1
Coordinates 3663709..3663918 (-) Length 70 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D51_RS17565 (L2D51_17565) 3659092..3659889 - 798 WP_123867361.1 TonB family protein -
L2D51_RS17570 (L2D51_17570) 3659992..3660831 - 840 WP_016926769.1 ChaN family lipoprotein -
L2D51_RS17575 (L2D51_17575) 3661009..3662418 + 1410 WP_033639696.1 S-methylmethionine permease -
L2D51_RS17580 (L2D51_17580) 3662408..3663346 + 939 WP_079450341.1 homocysteine S-methyltransferase -
L2D51_RS17585 (L2D51_17585) 3663356..3663712 - 357 WP_239442151.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
L2D51_RS17590 (L2D51_17590) 3663709..3663918 - 210 WP_004936539.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
L2D51_RS17595 (L2D51_17595) 3664019..3666298 - 2280 WP_016926766.1 NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase -
L2D51_RS24175 3666513..3666635 - 123 WP_275424762.1 hypothetical protein -
L2D51_RS17600 (L2D51_17600) 3666667..3667044 - 378 WP_151254468.1 DUF2570 family protein -
L2D51_RS17605 (L2D51_17605) 3667041..3667442 - 402 WP_079450343.1 M15 family metallopeptidase -
L2D51_RS17610 (L2D51_17610) 3667432..3667758 - 327 WP_004936551.1 phage holin, lambda family -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(26-79)

Antitoxin

(1-52)


Sequences


Toxin        


Download         Length: 119 a.a.        Molecular weight: 13193.95 Da        Isoelectric Point: 4.9139

>T232778 WP_239442151.1 NZ_CP091122:c3663712-3663356 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHSRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE

Download         Length: 357 bp

>T232778 NZ_CP128219:c99769-99371 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7749.96 Da        Isoelectric Point: 10.1768

>AT232778 WP_004936539.1 NZ_CP091122:c3663918-3663709 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR

Download         Length: 210 bp

>AT232778 NZ_CP128219:c100065-99772 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References