Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | phd-doc/Doc-RelB |
Location | 3663356..3663918 | Replicon | chromosome |
Accession | NZ_CP091122 | ||
Organism | Serratia marcescens strain CM2012_028 |
Toxin (Protein)
Gene name | doc | Uniprot ID | - |
Locus tag | L2D51_RS17585 | Protein ID | WP_239442151.1 |
Coordinates | 3663356..3663712 (-) | Length | 119 a.a. |
Antitoxin (Protein)
Gene name | phd | Uniprot ID | A0A8G2G5I1 |
Locus tag | L2D51_RS17590 | Protein ID | WP_004936539.1 |
Coordinates | 3663709..3663918 (-) | Length | 70 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
L2D51_RS17565 (L2D51_17565) | 3659092..3659889 | - | 798 | WP_123867361.1 | TonB family protein | - |
L2D51_RS17570 (L2D51_17570) | 3659992..3660831 | - | 840 | WP_016926769.1 | ChaN family lipoprotein | - |
L2D51_RS17575 (L2D51_17575) | 3661009..3662418 | + | 1410 | WP_033639696.1 | S-methylmethionine permease | - |
L2D51_RS17580 (L2D51_17580) | 3662408..3663346 | + | 939 | WP_079450341.1 | homocysteine S-methyltransferase | - |
L2D51_RS17585 (L2D51_17585) | 3663356..3663712 | - | 357 | WP_239442151.1 | type II toxin-antitoxin system death-on-curing family toxin | Toxin |
L2D51_RS17590 (L2D51_17590) | 3663709..3663918 | - | 210 | WP_004936539.1 | type II toxin-antitoxin system prevent-host-death family antitoxin | Antitoxin |
L2D51_RS17595 (L2D51_17595) | 3664019..3666298 | - | 2280 | WP_016926766.1 | NADP-dependent oxaloacetate-decarboxylating malate dehydrogenase | - |
L2D51_RS24175 | 3666513..3666635 | - | 123 | WP_275424762.1 | hypothetical protein | - |
L2D51_RS17600 (L2D51_17600) | 3666667..3667044 | - | 378 | WP_151254468.1 | DUF2570 family protein | - |
L2D51_RS17605 (L2D51_17605) | 3667041..3667442 | - | 402 | WP_079450343.1 | M15 family metallopeptidase | - |
L2D51_RS17610 (L2D51_17610) | 3667432..3667758 | - | 327 | WP_004936551.1 | phage holin, lambda family | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 119 a.a. Molecular weight: 13193.95 Da Isoelectric Point: 4.9139
>T232778 WP_239442151.1 NZ_CP091122:c3663712-3663356 [Serratia marcescens]
MIFLTAEDIAEFNAEIVPHSRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE
MIFLTAEDIAEFNAEIVPHSRQEGSKVEAVANRVLNAYHYENVTDVYRLAALYLIAISHGHIFLDGNKRTAFQSMALFLG
INGIALREDAELVEITVEAAQGRLNVEQAAEHLRRLTE
Download Length: 357 bp
>T232778 NZ_CP128219:c99769-99371 [Escherichia coli]
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
ATGCGGGTATTCAAAACAAAACTTATTCGCCTGCAACTTACAGCAGAGGAACTTGATGCGTTAACGGCGGATTTTATTTC
CTATAAGCGTGACGGTGTTTTGCCAGATATATTTGGTCGCGATGCACTCTACGACGACTCCTTTACCTGGCCATTAATCA
AATTTGAGCGAGTTGCTCATATTCATCTGGCAAATGAGAATAATCCATTTCCGCCACAGTTGCGCCAATTCAGCAGAACG
AATGACGAAGCGCATTTGGTATATTGTCAGGGGGCGTTTGATGAGCAAGCATGGTTGCTCATTGCCATTCTGAAACCTGA
ACCTCATAAACTGGCTCGAGATAACAACCAAATGCATAAAATTGGGAAAATGGCAGAAGCGTTTCGCATGCGTTTTTGA
Antitoxin
Download Length: 70 a.a. Molecular weight: 7749.96 Da Isoelectric Point: 10.1768
>AT232778 WP_004936539.1 NZ_CP091122:c3663918-3663709 [Serratia marcescens]
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR
MTTISYTAARNNLAEVLLEAQKQPVEVTRRGHDEVYIISKADYEVLVKAKVKARIQAKHADTIKALANR
Download Length: 210 bp
>AT232778 NZ_CP128219:c100065-99772 [Escherichia coli]
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
ATGCATCGAATTCTCGCTGAAAAATCGGTCAATATCACTGAGTTACGTAAAAACCCAGCTAAATACTTTATTGATCAACC
GGTTGCGGTTCTTTCTAATAATCGCCCCGCAGGATATCTCTTAAGTGCCAGCGCATTCGAAGCGTTAATGGACATGCTTG
CTGAACAAGAGGAGAAAAAGCCCATAAAGGCGCGCTTCCGTCCAAGTGCTGCAAGATTAGAGGAAATTACACGCCGCGCT
GAACAATATCTTAATGATATGACGGATGATGATTTCAATGACTTTAAGGAATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
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Structures
Toxin
Source | ID | Structure |
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Antitoxin
Source | ID | Structure |
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