23277

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /DUF1778(antitoxin)
Location 886001..886797 Replicon chromosome
Accession NC_011663
Organism Shewanella baltica OS223

Toxin (Protein)


Gene name - Uniprot ID B8ECY2
Locus tag SBAL223_RS03790 Protein ID WP_011847801.1
Coordinates 886267..886797 (+) Length 177 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID B8ECY1
Locus tag SBAL223_RS03785 Protein ID WP_012586779.1
Coordinates 886001..886270 (+) Length 90 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SBAL223_RS03765 882744..883418 + 675 WP_012586774.1 Fe2+-dependent dioxygenase -
SBAL223_RS03770 883856..884341 + 486 WP_012586775.1 hypothetical protein -
SBAL223_RS03775 884533..884946 + 414 WP_012586776.1 hypothetical protein -
SBAL223_RS03780 885173..885814 + 642 WP_012586777.1 hypothetical protein -
SBAL223_RS03785 886001..886270 + 270 WP_012586779.1 DUF1778 domain-containing protein Antitoxin
SBAL223_RS03790 886267..886797 + 531 WP_011847801.1 GNAT family N-acetyltransferase Toxin
SBAL223_RS03795 887144..887686 + 543 WP_041408338.1 hypothetical protein -
SBAL223_RS03800 887851..888132 + 282 WP_012586781.1 hypothetical protein -
SBAL223_RS24085 888397..888534 - 138 WP_012586783.1 hypothetical protein -
SBAL223_RS03805 888531..888761 - 231 WP_012586784.1 hypothetical protein -
SBAL223_RS03810 888758..889036 - 279 WP_012586785.1 hypothetical protein -
SBAL223_RS03815 889037..889330 - 294 WP_012089044.1 hypothetical protein -
SBAL223_RS03820 889327..890025 - 699 WP_012586786.1 hypothetical protein -
SBAL223_RS03825 890022..890612 - 591 WP_012586787.1 ead/Ea22-like family protein -
SBAL223_RS23680 890623..890787 - 165 WP_006083880.1 hypothetical protein -
SBAL223_RS03830 890824..891171 - 348 WP_011847795.1 hypothetical protein -
SBAL223_RS03835 891197..891457 - 261 WP_012586788.1 pyocin activator PrtN family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 882744..925861 43117


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

GNAT domain

(96-155)

Antitoxin

Vibrio phage ICP1, Orf50

(5-81)


Sequences

Toxin        


Download         Length: 177 a.a.        Molecular weight: 19727.98 Da        Isoelectric Point: 8.6014

>T23277 WP_011847801.1 NC_011663:886267-886797 [Shewanella baltica OS223]
VSYSKTFKELDKSQHDRASFDCGEAELNDFIQTQAAKHMQAGISRTMVLPAVTPLPNQKYPICSFYTIAPSSICRDTLPQ
AMGKKLPRYPIPVFLLAQLAVHKEFHGSGLGKASLIKALEYLWEINAHMRAYAIVVDCLTGQAESFYAKYGFEVLCEING
RVRMFIPMKTVGQLFT

Download         Length: 531 bp

>T23277 NC_011663:886267-886797 [Shewanella baltica OS223]
GTGAGTTATTCCAAGACTTTCAAAGAATTGGATAAATCACAACACGATAGAGCATCATTTGACTGTGGCGAAGCAGAGTT
AAACGATTTTATCCAAACTCAAGCAGCGAAACACATGCAAGCAGGTATTAGCCGTACAATGGTTTTACCTGCAGTTACAC
CATTGCCCAATCAAAAATACCCAATTTGTTCATTTTATACTATCGCACCAAGTTCAATTTGCCGTGATACCTTGCCGCAA
GCCATGGGTAAAAAGTTACCACGCTATCCCATTCCGGTCTTTCTGCTTGCTCAACTTGCCGTCCATAAAGAGTTTCACGG
TAGTGGGTTAGGTAAAGCTAGCTTAATCAAAGCACTAGAATATCTTTGGGAAATTAACGCTCACATGCGAGCTTATGCCA
TTGTGGTCGATTGCTTAACTGGCCAAGCTGAATCATTTTACGCTAAGTATGGTTTCGAGGTTCTTTGTGAAATCAACGGT
CGTGTAAGAATGTTTATTCCAATGAAAACAGTCGGTCAGTTATTCACTTAG

Antitoxin


Download         Length: 90 a.a.        Molecular weight: 9903.38 Da        Isoelectric Point: 4.9059

>AT23277 WP_012586779.1 NC_011663:886001-886270 [Shewanella baltica OS223]
MATARLDIRLDEEIKAKAEKASALLGLKSLTEYVVRLMDEDSTQVIAEHESITVKADVFDQFIMACDEAKAPNKALREAA
AFTKRGEFK

Download         Length: 270 bp

>AT23277 NC_011663:886001-886270 [Shewanella baltica OS223]
ATGGCGACTGCAAGACTTGATATCCGATTGGATGAAGAGATCAAAGCTAAGGCTGAGAAAGCATCGGCTTTGCTTGGTTT
AAAAAGCTTAACTGAATACGTTGTTCGCTTAATGGACGAAGATTCAACTCAGGTGATTGCTGAGCATGAAAGCATTACTG
TTAAAGCTGATGTATTCGACCAATTCATAATGGCTTGTGATGAGGCTAAGGCCCCGAACAAGGCATTGCGTGAAGCGGCA
GCATTTACTAAACGTGGTGAGTTTAAGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A3D8P0

Antitoxin

Source ID Structure
AlphaFold DB A0A2K8ZIQ4

References