Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) ccdAB/CcdA(antitoxin)
Location 1550263..1550811 Replicon chromosome
Accession NZ_CP091122
Organism Serratia marcescens strain CM2012_028

Toxin (Protein)


Gene name ccdB Uniprot ID -
Locus tag L2D51_RS07490 Protein ID WP_240294078.1
Coordinates 1550509..1550811 (+) Length 101 a.a.

Antitoxin (Protein)


Gene name ccdA Uniprot ID -
Locus tag L2D51_RS07485 Protein ID WP_025302143.1
Coordinates 1550263..1550499 (+) Length 79 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D51_RS07470 (L2D51_07470) 1546749..1548284 + 1536 WP_016928459.1 glutathione ABC transporter substrate-binding protein GsiB -
L2D51_RS07475 (L2D51_07475) 1548337..1549257 + 921 WP_016928458.1 glutathione ABC transporter permease GsiC -
L2D51_RS07480 (L2D51_07480) 1549267..1550175 + 909 WP_195905501.1 glutathione ABC transporter permease GsiD -
L2D51_RS07485 (L2D51_07485) 1550263..1550499 + 237 WP_025302143.1 type II toxin-antitoxin system CcdA family antitoxin Antitoxin
L2D51_RS07490 (L2D51_07490) 1550509..1550811 + 303 WP_240294078.1 CcdB family protein Toxin
L2D51_RS07495 (L2D51_07495) 1550847..1551689 - 843 WP_240293960.1 S-formylglutathione hydrolase -
L2D51_RS07500 (L2D51_07500) 1551704..1552828 - 1125 WP_016928454.1 S-(hydroxymethyl)glutathione dehydrogenase/class III alcohol dehydrogenase -
L2D51_RS07505 (L2D51_07505) 1552859..1553779 - 921 WP_110146819.1 LysR family transcriptional regulator -
L2D51_RS07510 (L2D51_07510) 1553885..1555042 + 1158 WP_151254874.1 YbfB/YjiJ family MFS transporter -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin CcdB

(3-99)

Antitoxin

Post-segregation antitoxin CcdA

(8-78)


Sequences

Toxin        


Download         Length: 101 a.a.        Molecular weight: 11180.95 Da        Isoelectric Point: 5.0196

>T232768 WP_240294078.1 NZ_CP091122:1550509-1550811 [Serratia marcescens]
IAVYDNTYPASAYPYLLDVQSDLIDVLSTRLMIPLYALDNVRVKISARLCPEIEVNGEKFLVMTHEMAAVRISQIGKAVG
NVNEHRNQIKAAIDFLIDGF

Download         Length: 303 bp

>T232768 NZ_CP128218:c2660319-2659912 [Escherichia coli]
GTGGTCCTGTGGCAATCTGATTTGCGCGTCTCCTGGCGCGCACAGTGGCTTTCCTTGCTGATTCATGGGCTGGTTGCCGC
TGTTATTTTACTCATGCCCTGGCCACTCAGTTACACCCCGTTATGGATGGTGTTACTTTCGCTGGTGGTGTTTGATTGCG
TTCGCAGCCAGCGGCGTATTAATGCTCGCCAGGGGGAAATTCGCTTGTTGATGGACGGGCGTTTGCGTTGGCAAGGGCAG
GAGTGGAGCATCGTCAAAGCACCGTGGATGATTAAGAGCGGCATGATGCTGCGTTTACGTTCTGATGGCGGTAAACGGCA
ACATTTATGGCTGGCAGCCGACAGCATGGACGAAGCTGAATGGCGGGATTTACGGCGGATTTTGTTGCAACAAGAGACGC
AAAGATAA

Antitoxin


Download         Length: 79 a.a.        Molecular weight: 8967.04 Da        Isoelectric Point: 5.0807

>AT232768 WP_025302143.1 NZ_CP091122:1550263-1550499 [Serratia marcescens]
MANSNVTKKTVNVTIDRDLFQRAKSLGVNVSSVLTDALSVRVRDIEIQQWREQNRAALEELNRITEENGLLSDEYRTF

Download         Length: 237 bp

>AT232768 NZ_CP128218:c2660566-2660300 [Escherichia coli]
ATGGACATTAACAACAAAGCCCGCATTCATTGGGCATGCCGCCGTGGTATGCGCGAACTCGATATTTCAATCATGCCGTT
TTTCGAACATGAGTACGACAGCTTAAGCGATGACGAAAAACGCATCTTTATTCGTCTGCTGGAATGTGACGATCCGGACC
TGTTTAACTGGCTGATGAATCACGGTAAACCGGCCGATGCAGAACTGGAAATGATGGTCCGACTCATCCAGACACGGAAC
CGGGAACGTGGTCCTGTGGCAATCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References