Detailed information of TA system TA023276

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-couple_hipB
• Location: 811294..812835
• Replicon: chromosome
• Accession: NC_011663
• Organism: Shewanella baltica OS223

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: B8E9H5
• Locus tag: SBAL223_RS03430
• Protein ID: WP_012586736.1
• Coordinates: 811534..812835 (+)
• Length: 434 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: SBAL223_RS03425
• Protein ID: WP_012586735.1
• Coordinates: 811294..811530 (+)
• Length: 79 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
SBAL223_RS03405	806320..807309	+	990	WP_012586733.1	LysR family transcriptional regulator	-
SBAL223_RS03410	807311..808678	-	1368	WP_012586734.1	MATE family efflux transporter	-
SBAL223_RS03415	808903..809193	+	291	WP_006086113.1	co-chaperone GroES	-
SBAL223_RS03420	809251..810888	+	1638	WP_011847850.1	chaperonin GroEL	-
SBAL223_RS03425	811294..811530	+	237	WP_012586735.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
SBAL223_RS03430	811534..812835	+	1302	WP_012586736.1	HipA domain-containing protein	Toxin
SBAL223_RS03435	813269..813733	+	465	WP_041408575.1	hypothetical protein	-
SBAL223_RS03440	814267..814653	+	387	WP_012586738.1	carboxymuconolactone decarboxylase family protein	-
SBAL223_RS03445	814812..815063	-	252	WP_006083102.1	DUF2999 domain-containing protein	-
SBAL223_RS03450	815405..816901	+	1497	WP_012586739.1	ATP-binding cassette domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA-like, C-terminal (146-387)

Antitoxin

• Cro/C1-type helix-turn-helix domain (11-64)

Sequences

Toxin

Protein

• Length: 434 a.a.
• Molecular weight: 48485.68 Da
• Isoelectric Point: 5.3112

>T23276 WP_012586736.1 NC_011663:811534-812835 [Shewanella baltica OS223]
MSTSKKLTLEMHLGDLMIGELSFDATTDTFAVHYTKDWQQSGFPLSPTIPLDGTGSSSQISMFLVNLLPENKGLDYLIES
LGVSKGNTFALIRAIGLDTAGAVAFVPKGTLLPETQLRPIKAEEVIQRIEDPTMWPMEIWDGKPRLSVAGVQPKLNLFYN
GEEFAFAEGALSSTHIVKFEKYRHLVLNEFMTMRLAKAIGMNVANVDIVHFGDYKVLCVERFDRRYIPNAQKVLRRHIVD
SCQALGFSVSKKYERNFGSGRDVKDIREGVSFNRLFSLAAKCRNPVAAKQDMLQWTLFNLLTGNADAHGKNYSFFMTPSG
MEPTPWYDLVSVAMYEDFEQQLAMAIDDEFDPNSIYAYQLAAFIDGLGLPRNLLISNLTSIAQRIPQAIAEVVSMLPALD
ESETVFVAHYKAQLLARCDRYLSFAAEVRDVEV

Nucleotide

• Length: 1302 bp

>T23276 NC_011663:811534-812835 [Shewanella baltica OS223]
ATGAGTACTTCCAAAAAGCTCACGTTAGAGATGCACCTCGGTGATTTAATGATCGGGGAGCTATCCTTTGATGCGACGAC
CGACACCTTTGCCGTACATTACACCAAAGACTGGCAACAAAGTGGATTCCCACTATCCCCAACAATTCCCTTAGATGGCA
CAGGAAGTAGCAGTCAGATATCGATGTTTTTGGTTAACTTATTACCGGAAAACAAAGGATTAGATTATCTAATTGAATCC
CTTGGCGTCTCCAAGGGAAATACCTTTGCCTTGATCCGCGCCATTGGTCTCGATACTGCAGGTGCTGTTGCTTTTGTTCC
TAAAGGGACTTTGCTGCCTGAAACACAATTACGGCCAATTAAGGCTGAAGAAGTTATTCAGCGAATTGAAGATCCCACAA
TGTGGCCGATGGAAATTTGGGACGGCAAACCTCGACTGTCGGTAGCGGGTGTACAACCTAAATTAAACCTGTTTTATAAC
GGTGAAGAATTTGCATTTGCCGAAGGCGCACTGTCATCTACCCATATTGTTAAATTCGAAAAATATCGCCATTTAGTGCT
CAATGAATTTATGACGATGCGCTTAGCCAAGGCGATTGGAATGAATGTGGCTAATGTTGATATCGTTCATTTTGGAGATT
ACAAAGTACTCTGTGTCGAACGCTTTGACCGACGTTATATACCAAATGCGCAAAAGGTATTAAGAAGACATATTGTCGAT
AGCTGCCAAGCTCTTGGTTTTAGTGTTAGCAAAAAATATGAACGTAATTTTGGTTCAGGGCGTGATGTTAAAGATATTCG
TGAAGGGGTAAGTTTTAACAGGCTCTTTAGTCTCGCAGCAAAATGCCGCAATCCAGTGGCTGCTAAGCAAGACATGTTGC
AATGGACGCTGTTCAATTTACTGACCGGCAATGCCGATGCACACGGTAAAAACTATTCGTTTTTTATGACGCCAAGCGGA
ATGGAGCCAACTCCTTGGTACGATTTGGTCAGCGTGGCTATGTATGAGGATTTTGAACAACAGCTTGCGATGGCAATCGA
TGACGAATTTGATCCAAACAGCATTTACGCGTATCAATTGGCCGCATTTATTGATGGCTTAGGTTTACCAAGAAATCTAT
TAATCAGTAACTTAACGTCAATAGCGCAAAGAATACCGCAGGCAATAGCTGAGGTGGTTTCAATGCTCCCAGCTCTCGAT
GAGAGTGAAACAGTATTTGTGGCTCATTACAAAGCGCAGTTGCTGGCGAGATGTGATCGTTACCTTAGTTTTGCCGCCGA
GGTCAGGGATGTCGAAGTGTAG

Antitoxin

Protein

• Length: 79 a.a.
• Molecular weight: 8544.89 Da
• Isoelectric Point: 7.9728

>AT23276 WP_012586735.1 NC_011663:811294-811530 [Shewanella baltica OS223]
MASRLNQQSLGLLIKERRKSAALTQDVAAMLCGVTKKTLIRVEKGEDVYISTVFKILDGLGIDIVAAQTSDTETNGWY

Nucleotide

• Length: 237 bp

>AT23276 NC_011663:811294-811530 [Shewanella baltica OS223]
ATGGCATCACGGCTAAATCAACAATCCCTCGGCTTGTTAATTAAAGAACGAAGGAAAAGTGCTGCTCTTACTCAAGACGT
GGCGGCCATGCTGTGCGGCGTAACCAAAAAAACGCTGATCCGAGTTGAAAAAGGTGAGGATGTTTATATCTCAACCGTAT
TCAAAATCCTAGATGGTCTGGGGATTGATATCGTTGCGGCTCAAACCAGCGACACCGAAACTAACGGCTGGTATTAA

Structures

Toxin

• AlphaFold DB: B8E9H5