Detailed information of TA system    

insolicoBioinformatically predicted

Overview


TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 4165821..4166490 Replicon chromosome
Accession NZ_CP091120
Organism Serratia marcescens strain CM2019_254

Toxin (Protein)


Gene name cptA Uniprot ID -
Locus tag L2D50_RS19770 Protein ID WP_025304123.1
Coordinates 4165821..4166243 (-) Length 141 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID A0A8G2G4M4
Locus tag L2D50_RS19775 Protein ID WP_004931679.1
Coordinates 4166224..4166490 (-) Length 89 a.a.

Genomic Context


Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D50_RS19750 (L2D50_19750) 4161710..4162228 + 519 WP_025304119.1 flavodoxin FldB -
L2D50_RS19755 (L2D50_19755) 4162266..4163630 - 1365 WP_025304120.1 cell envelope integrity protein CreD -
L2D50_RS19760 (L2D50_19760) 4163711..4165129 - 1419 WP_089181251.1 two-component system sensor histidine kinase CreC -
L2D50_RS19765 (L2D50_19765) 4165126..4165821 - 696 WP_025304122.1 two-component system response regulator CreB -
L2D50_RS19770 (L2D50_19770) 4165821..4166243 - 423 WP_025304123.1 protein YgfX Toxin
L2D50_RS19775 (L2D50_19775) 4166224..4166490 - 267 WP_004931679.1 FAD assembly factor SdhE Antitoxin
L2D50_RS19780 (L2D50_19780) 4166811..4167803 + 993 WP_025304124.1 tRNA-modifying protein YgfZ -
L2D50_RS19785 (L2D50_19785) 4167842..4168339 - 498 WP_025304125.1 DUF2165 domain-containing protein -
L2D50_RS19790 (L2D50_19790) 4168490..4169164 - 675 WP_033639467.1 hemolysin III family protein -
L2D50_RS19795 (L2D50_19795) 4169348..4169956 + 609 WP_025304127.1 HD domain-containing protein -
L2D50_RS19800 (L2D50_19800) 4169996..4170922 - 927 WP_025304128.1 ribokinase -

Associated MGEs


MGE
detail
Similar
MGEs
Relative
position
MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains


Predicted by InterproScan

Toxin

(2-131)

Antitoxin

(7-79)


Sequences


Toxin        


Download         Length: 141 a.a.        Molecular weight: 16525.62 Da        Isoelectric Point: 10.8432

>T232749 WP_025304123.1 NZ_CP091120:c4166243-4165821 [Serratia marcescens]
VAQWRCDIRISWRTQLFSLLTHGVLILLILISPWPEGYGPLWLVLLTLVVFQCIRSQKRIAAVQGELRLLADRRFSWHGR
EWRLAKKPWMPGYGLLLTLQPMEGKKRRRLWLASDCMSKEEWRHLRQLLLYPPAGNGEEP

Download         Length: 423 bp

>T232749 NZ_CP128214:514083-514352 [Agrobacterium fabrum]
ATGAAGCTCGTCTGGACGCTGAGTTCATGGGACGACTATGAGTTCTGGCAAAGAACCGATGCTCGCATGGTCGAGAAAAT
AAACGATCTTATCCGAAATGCCAAACGCACGCCCTTTGCAGGGCTTGGGAAACCGGAGCCTCTGAAGGGCGATATGGCAG
GATATTGGTCTCGGCGGATTACCGCCGAGCATCGGTTTGTCTACCGTGTATCCGGGTCCGGAAGCGAGCAACGGCTGGAA
GTCATTCAGTGCCGCTTCCATTACCAATAA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10387.89 Da        Isoelectric Point: 4.7921

>AT232749 WP_004931679.1 NZ_CP091120:c4166490-4166224 [Serratia marcescens]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDSLNDADKALFIRLLECDDPDLFNWLMNHGAPQDGELQRMVTLIQTRN
KDRGPVAM

Download         Length: 267 bp

>AT232749 NZ_CP128214:513832-514086 [Agrobacterium fabrum]
ATGGCGAATGTGCGATTTACCGAGTTCAGGCAGAACTTCGCGACCCATTTCGACCGGGTTCTGGAAACCCGCGCGCCATT
GCTCGTCACGCGGCAAGGCAAAGAGGCGGTCGTGGTGCTTGCCGAAGGAGAATATGAGAGCATGCAGGAAACGCTGCATC
TCCTGTCCAACCCGGCAAATGCCTCAAGGCTTCGCGCGTCCATGGGCGAACTTGAGCGCGGTGACACCATCGAGCGGGAT
CCGACCGAAGAATGA

Similar Proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures


Toxin

Source ID Structure


Antitoxin

Source ID Structure

References