Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/RelE-HTH
Location 4157447..4158170 Replicon chromosome
Accession NZ_CP091120
Organism Serratia marcescens strain CM2019_254

Toxin (Protein)


Gene name relE Uniprot ID -
Locus tag L2D50_RS19725 Protein ID WP_049296187.1
Coordinates 4157447..4157833 (+) Length 129 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID -
Locus tag L2D50_RS19730 Protein ID WP_025304117.1
Coordinates 4157826..4158170 (+) Length 115 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D50_RS19705 (L2D50_19705) 4152826..4154136 + 1311 WP_142591589.1 MFS transporter -
L2D50_RS19715 (L2D50_19715) 4154560..4156077 - 1518 WP_004931697.1 lysine--tRNA ligase -
L2D50_RS19725 (L2D50_19725) 4157447..4157833 + 387 WP_049296187.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
L2D50_RS19730 (L2D50_19730) 4157826..4158170 + 345 WP_025304117.1 helix-turn-helix domain-containing protein Antitoxin
L2D50_RS19735 (L2D50_19735) 4158221..4159954 - 1734 WP_016929971.1 single-stranded-DNA-specific exonuclease RecJ -
L2D50_RS19740 (L2D50_19740) 4159961..4160677 - 717 WP_025304118.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L2D50_RS19745 (L2D50_19745) 4160704..4161624 - 921 WP_154747450.1 site-specific tyrosine recombinase XerD -
L2D50_RS19750 (L2D50_19750) 4161710..4162228 + 519 WP_025304119.1 flavodoxin FldB -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin HigB-2

(1-124)

Antitoxin

Cro/C1-type helix-turn-helix domain

(54-91)


Sequences

Toxin        


Download         Length: 129 a.a.        Molecular weight: 14614.65 Da        Isoelectric Point: 9.4235

>T232748 WP_049296187.1 NZ_CP091120:4157447-4157833 [Serratia marcescens]
MDIFVTDDFDKFMKKNRIVDQKICTAAHELAHGNHDGDLGGGVYKKRISLNRGKRGGARSIVAFKRGRHQYFIDGWLKNT
VKQNGAKEINDDELATYRELARDFLAMPPEIIKRAIDSGYLREVKCDD

Download         Length: 387 bp

>T232748 NZ_CP128206:57030-57332 [Vibrio furnissii]
ATGAGCAGTTATAAGCTTTCACCTTTAGCCCAGTCTGATCTCACTGATATTCGTCGTTACACCATAGAACATTGGGGCAG
TACTCAATGGTCCGTCTATTTTAATGAATTACAGGAATCGATGTCATTGCTGGCAAGTAACGAACTGATCGGAATTCAGA
TCCCGGAAATGGGAGAGCGATACTACCGTTTTCCTCTGAAGCACCATGTGATTTATTACATCACTCAGGAAGACCATATC
GTTATCGTCGCTGTGCTGGGTAAGCATATGTCTCCTGCAAAACATTTTGCGTCTATTTCTTAA

Antitoxin


Download         Length: 115 a.a.        Molecular weight: 12919.85 Da        Isoelectric Point: 11.4121

>AT232748 WP_025304117.1 NZ_CP091120:4157826-4158170 [Serratia marcescens]
MTDNRLLRLQKMAQRFNEIGAVSDDTVRNIATRVQAQEQHAQREQHDQMDGARIKMLRRRLGLSQADLAAVVNMSTTSVQ
KWERNAVKPQGAALRMLEIIEQKGVASLIISPRN

Download         Length: 345 bp

>AT232748 NZ_CP128206:56770-57015 [Vibrio furnissii]
ATGCAATCATTAACAGCAAATACAGCAAAAACCAAATTTGGCGATTTACTGATGAAGGTTCAGCGTGAACCCGTGCAAAT
CAGTAAAAATGGCTCACCGGTTGCGGTGATGATGTCCTGTGAAGAATATGAGCAATTAGAAGCACTCAAGATGATGCTGG
TTAAATCTCGTTTTGAACAGGCAGAAATTGATATCAGGAATGGCGATCTGGTCGATGGTGATGAATTTATGAAATCTCTG
GCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References