Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) vapBC/VapC-VagC
Location 3803100..3803756 Replicon chromosome
Accession NZ_CP091120
Organism Serratia marcescens strain CM2019_254

Toxin (Protein)


Gene name vapC Uniprot ID -
Locus tag L2D50_RS18045 Protein ID WP_043137970.1
Coordinates 3803100..3803489 (-) Length 130 a.a.

Antitoxin (Protein)


Gene name vapB Uniprot ID A0A8G2LCA8
Locus tag L2D50_RS18050 Protein ID WP_004941563.1
Coordinates 3803493..3803756 (-) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L2D50_RS18030 (L2D50_18030) 3799567..3800997 + 1431 WP_049296101.1 MFS transporter -
L2D50_RS18035 (L2D50_18035) 3800994..3802376 + 1383 WP_147824120.1 two-component system sensor histidine kinase BaeS -
L2D50_RS18040 (L2D50_18040) 3802376..3803092 + 717 WP_004941568.1 two-component system response regulator BaeR -
L2D50_RS18045 (L2D50_18045) 3803100..3803489 - 390 WP_043137970.1 type II toxin-antitoxin system VapC family toxin Toxin
L2D50_RS18050 (L2D50_18050) 3803493..3803756 - 264 WP_004941563.1 AbrB/MazE/SpoVT family DNA-binding domain-containing protein Antitoxin
L2D50_RS18055 (L2D50_18055) 3804094..3804432 + 339 WP_016926703.1 YegP family protein -
L2D50_RS18060 (L2D50_18060) 3804611..3805963 + 1353 WP_025303865.1 tRNA 5-hydroxyuridine modification protein YegQ -
L2D50_RS18065 (L2D50_18065) 3806180..3806401 - 222 WP_141998673.1 hypothetical protein -
L2D50_RS18070 (L2D50_18070) 3806431..3807336 + 906 WP_197791343.1 lipid kinase YegS -
L2D50_RS18075 (L2D50_18075) 3807505..3808719 + 1215 WP_025303867.1 D-galactonate dehydratase family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

PIN domain

(2-119)

Antitoxin


No domain identified.



Sequences

Toxin        


Download         Length: 130 a.a.        Molecular weight: 14451.78 Da        Isoelectric Point: 9.0823

>T232746 WP_043137970.1 NZ_CP091120:c3803489-3803100 [Serratia marcescens]
MYMFDTNTVSHLFRQHPQVLNVMQKLPPSAVCISSVTEAELLYGVAKRRNKALQSMVEAFLAAVTVYAWDREAARCYGEM
RANMVRKDKIMGAMDQLIAAHAQSRGATLVTNDRAFAMVPGLAVEDWTR

Download         Length: 390 bp

>T232746 NZ_CP128202:51358-51660 [Vibrio furnissii]
ATGAGCAGTTATAAGCTTTCACCTTTAGCCCAGTCTGATCTCACTGATATTCGTCGTTACACCATAGAACATTGGGGCAG
TACTCAATGGTCCGTCTATTTTAATGAATTACAGGAATCGATGTCATTGCTGGCAAGTAACGAACTGATCGGAATTCAGA
TCCCGGAAATGGGAGAGCGATACTACCGTTTTCCTCTGAAGCACCATGTGATTTATTACATCACTCAGGAAGACCATATC
GTTATCGTCGCTGTGCTGGGTAAGCATATGTCTCCTGCAAAACATTTTGCGTCTATTTCTTAA

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10062.31 Da        Isoelectric Point: 4.6702

>AT232746 WP_004941563.1 NZ_CP091120:c3803756-3803493 [Serratia marcescens]
MERIAKLFKNGRNQAVRLPVEFEFDTDRVYIRRDREGNVILSKYPAKPDSWAPLLSIIAQTPVPQEFLGAEDRQQGVADR
DPFSEEE

Download         Length: 264 bp

>AT232746 NZ_CP128202:51098-51343 [Vibrio furnissii]
ATGCAATCATTAACAGCAAATACAGCAAAAACCAAATTTGGCGATTTACTGATGAAGGTTCAGCGTGAACCCGTGCAAAT
CAGTAAAAATGGCTCACCGGTTGCGGTGATGATGTCCTGTGAAGAATATGAGCAATTAGAAGCACTCAAGATGATGCTGG
TTAAATCTCGTTTTGAACAGGCAGAAATTGATATCAGGAATGGCGATCTGGTCGATGGTGATGAATTTATGAAATCTCTG
GCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References