Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | parDE/ParE-YefM |
| Location | 1421332..1421899 | Replicon | chromosome |
| Accession | NZ_CP091120 | ||
| Organism | Serratia marcescens strain CM2019_254 | ||
Toxin (Protein)
| Gene name | parE | Uniprot ID | - |
| Locus tag | L2D50_RS06755 | Protein ID | WP_028127915.1 |
| Coordinates | 1421332..1421637 (-) | Length | 102 a.a. |
Antitoxin (Protein)
| Gene name | parD | Uniprot ID | A0A8B4G8D1 |
| Locus tag | L2D50_RS06760 | Protein ID | WP_016928576.1 |
| Coordinates | 1421639..1421899 (-) | Length | 87 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L2D50_RS06720 (L2D50_06720) | 1416980..1418056 | + | 1077 | WP_025302022.1 | urea ABC transporter permease subunit UrtC | - |
| L2D50_RS06725 (L2D50_06725) | 1418053..1418859 | + | 807 | WP_015377102.1 | urea ABC transporter ATP-binding protein UrtD | - |
| L2D50_RS06730 (L2D50_06730) | 1418872..1419570 | + | 699 | WP_046686646.1 | urea ABC transporter ATP-binding subunit UrtE | - |
| L2D50_RS06735 (L2D50_06735) | 1419578..1419877 | - | 300 | WP_049295232.1 | type II toxin-antitoxin system RelE/ParE family toxin | - |
| L2D50_RS06740 (L2D50_06740) | 1419862..1420125 | - | 264 | WP_004939442.1 | type II toxin-antitoxin system ParD family antitoxin | - |
| L2D50_RS06745 (L2D50_06745) | 1420260..1420772 | + | 513 | WP_089195646.1 | DUF2165 family protein | - |
| L2D50_RS06750 (L2D50_06750) | 1420795..1421307 | - | 513 | WP_049208922.1 | GNAT family N-acetyltransferase | - |
| L2D50_RS06755 (L2D50_06755) | 1421332..1421637 | - | 306 | WP_028127915.1 | type II toxin-antitoxin system RelE/ParE family toxin | Toxin |
| L2D50_RS06760 (L2D50_06760) | 1421639..1421899 | - | 261 | WP_016928576.1 | type II toxin-antitoxin system Phd/YefM family antitoxin | Antitoxin |
| L2D50_RS06765 (L2D50_06765) | 1421968..1423203 | - | 1236 | WP_060432678.1 | FAD-dependent oxidoreductase | - |
| L2D50_RS06770 (L2D50_06770) | 1423280..1423849 | - | 570 | WP_169540378.1 | DUF4865 family protein | - |
| L2D50_RS06775 (L2D50_06775) | 1423955..1424824 | + | 870 | WP_025302028.1 | LysR substrate-binding domain-containing protein | - |
| L2D50_RS06780 (L2D50_06780) | 1424821..1425666 | - | 846 | WP_049203902.1 | 3-mercaptopyruvate sulfurtransferase | - |
| L2D50_RS06785 (L2D50_06785) | 1425773..1426195 | + | 423 | WP_049203903.1 | NUDIX hydrolase | - |
| L2D50_RS06790 (L2D50_06790) | 1426206..1426871 | - | 666 | WP_197790591.1 | epimerase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 102 a.a. Molecular weight: 11954.71 Da Isoelectric Point: 9.5902
>T232735 WP_028127915.1 NZ_CP091120:c1421637-1421332 [Serratia marcescens]
MPAFRLTPQAQQDLLAIRHFTIEHWGQAQSRRYLEQLREVMHHLADMPEAGKAHFHDLGEEIRSFPYASHRIYYRNRPAG
ITVLAILHQAMVPHRHLEQRL
MPAFRLTPQAQQDLLAIRHFTIEHWGQAQSRRYLEQLREVMHHLADMPEAGKAHFHDLGEEIRSFPYASHRIYYRNRPAG
ITVLAILHQAMVPHRHLEQRL
Download Length: 306 bp
>T232735 NZ_CP128192:c74652-74368 [Klebsiella pneumoniae]
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA
ATGACTTATAAGCTGGCCTTTAATGAATCAGCTCTGAAAGAATGGAAAAAATTGGGCCATACCATTCGGGAACAATTCAA
AAAGAAGCTCGCTGAGCGCCTGTTGAACCCACGGGTGCCCGCATCGCAACTACATGGACGCAAAGACCAATACAAAATAA
AGCTCCGTGGCGCAGGCTACCGACTGGTTTACAGTGTCAACGATGATGTTGTGACGGTCACCGTAATTGGCGTCGGTAAA
CGTGAGAATGATGATATTTACAATTTAACCAAACACAGAAATTAA
Antitoxin
Download Length: 87 a.a. Molecular weight: 9442.59 Da Isoelectric Point: 4.1964
>AT232735 WP_016928576.1 NZ_CP091120:c1421899-1421639 [Serratia marcescens]
MYALTANEAKTQFGDLLLKAQREPVQINRNGKPVAVVMSVEDYQALEDLKLSALQQKIAQATAEEDAGKAVDGDAFFNRL
LTDETD
MYALTANEAKTQFGDLLLKAQREPVQINRNGKPVAVVMSVEDYQALEDLKLSALQQKIAQATAEEDAGKAVDGDAFFNRL
LTDETD
Download Length: 261 bp
>AT232735 NZ_CP128192:c74890-74642 [Klebsiella pneumoniae]
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCTGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA
ATGGCATTTCAGGTACTAACCACTACTGCAGCAAGCATCACAGAGCTTAAACGTGATCCTATGGGCACTTTCAATGCAGG
AGAAGGTGCCCCTGTAGCCATACTGAATCGCAACGAACCCGCTTTTTACTGTGTACCGCCTGCTCTGTATGCTCAACTGA
TGGAGCTTCTTGAAGATCAGGAGCTGGGTCGTATTGCTGATGAGCGAATTGGTGAGGCGGTAATCGAGGTCAGTCTAGAT
GACTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|