Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) stbE-relB/ParE-YafN
Location 2967655..2968213 Replicon chromosome
Accession NC_011662
Organism Thauera sp. MZ1T

Toxin (Protein)


Gene name stbE Uniprot ID C4KAC0
Locus tag TMZ1T_RS13100 Protein ID WP_012585651.1
Coordinates 2967655..2967975 (-) Length 107 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C4KAC1
Locus tag TMZ1T_RS13105 Protein ID WP_012585652.1
Coordinates 2967962..2968213 (-) Length 84 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TMZ1T_RS13085 2962775..2966290 + 3516 Protein_2622 class I SAM-dependent DNA methyltransferase -
TMZ1T_RS20610 2966340..2966759 + 420 WP_144312221.1 putative toxin-antitoxin system toxin component, PIN family -
TMZ1T_RS13090 2966756..2966977 + 222 WP_012585648.1 ribbon-helix-helix domain-containing protein -
TMZ1T_RS21350 2967024..2967179 + 156 WP_012585649.1 hypothetical protein -
TMZ1T_RS13095 2967318..2967608 + 291 WP_086014418.1 BrnA antitoxin family protein -
TMZ1T_RS13100 2967655..2967975 - 321 WP_012585651.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TMZ1T_RS13105 2967962..2968213 - 252 WP_012585652.1 type II toxin-antitoxin system prevent-host-death family antitoxin Antitoxin
TMZ1T_RS21355 2968578..2968733 + 156 WP_187283066.1 hypothetical protein -
TMZ1T_RS13110 2968935..2970572 + 1638 WP_012585654.1 alpha-D-glucose phosphate-specific phosphoglucomutase -
TMZ1T_RS13115 2970698..2972548 - 1851 WP_012585655.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(26-92)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(9-77)


Sequences

Toxin        


Download         Length: 107 a.a.        Molecular weight: 12104.12 Da        Isoelectric Point: 9.9150

>T23273 WP_012585651.1 NC_011662:c2967975-2967655 [Thauera sp. MZ1T]
MSSSESPPPRYRLKFLPDALDEWNALDGSVKEVLKKLLRKRLEHPRVPGAELHGDLRDCYKIKLRKQGYRLVYQVEEGVL
TVLVLAVAKREDMAAYRAAVDRLLSG

Download         Length: 321 bp

>T23273 NC_011662:c2967975-2967655 [Thauera sp. MZ1T]
TTGAGCAGCTCTGAATCGCCGCCGCCGCGCTATCGACTGAAGTTCCTGCCCGACGCCCTCGACGAATGGAACGCTCTCGA
CGGCAGCGTCAAGGAAGTGCTCAAGAAACTGCTGAGGAAGCGTCTGGAGCATCCCAGGGTGCCAGGGGCTGAGCTTCATG
GCGATCTGCGTGACTGCTACAAGATCAAGTTGCGCAAGCAAGGCTACCGGCTCGTTTACCAGGTCGAAGAAGGTGTGCTG
ACCGTTCTCGTTCTTGCAGTGGCGAAGCGCGAAGACATGGCCGCGTATCGCGCCGCTGTGGATCGCCTGTTGTCCGGTTG
A

Antitoxin


Download         Length: 84 a.a.        Molecular weight: 9372.81 Da        Isoelectric Point: 4.8228

>AT23273 WP_012585652.1 NC_011662:c2968213-2967962 [Thauera sp. MZ1T]
VDAIYADFSVSMSEFKKNPAQVLRTAGEKPVAVLNHNRPAFYMVTPKLFEALIEELADRDLVELARQRLAKKAEAIEVDL
EQL

Download         Length: 252 bp

>AT23273 NC_011662:c2968213-2967962 [Thauera sp. MZ1T]
GTGGATGCGATCTATGCCGATTTCTCGGTCAGCATGTCCGAGTTCAAGAAGAACCCCGCACAGGTCCTGCGTACGGCCGG
GGAAAAGCCCGTGGCGGTTCTCAACCACAATCGTCCTGCCTTCTACATGGTGACGCCGAAGCTGTTCGAGGCGCTGATCG
AGGAGTTGGCAGACCGCGACCTGGTCGAGCTTGCGCGGCAGCGACTGGCCAAGAAAGCTGAGGCGATCGAGGTCGATCTT
GAGCAGCTCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C3MXQ3

Antitoxin

Source ID Structure
AlphaFold DB A0A0C3ISD3

References