Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relE-yefM/Txe-RelB
Location 1993148..1993677 Replicon chromosome
Accession NZ_CP091100
Organism Enterococcus faecium strain P47

Toxin (Protein)


Gene name relE Uniprot ID C9B8W9
Locus tag L1881_RS09740 Protein ID WP_002294198.1
Coordinates 1993411..1993677 (+) Length 89 a.a.

Antitoxin (Protein)


Gene name yefM Uniprot ID C9B8W8
Locus tag L1881_RS09735 Protein ID WP_002294199.1
Coordinates 1993148..1993411 (+) Length 88 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1881_RS09725 (L1881_09725) 1990523..1992346 + 1824 WP_002294202.1 APC family permease -
L1881_RS09730 (L1881_09730) 1992488..1992673 - 186 WP_002294201.1 hypothetical protein -
L1881_RS09735 (L1881_09735) 1993148..1993411 + 264 WP_002294199.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L1881_RS09740 (L1881_09740) 1993411..1993677 + 267 WP_002294198.1 Txe/YoeB family addiction module toxin Toxin
L1881_RS09745 (L1881_09745) 1993878..1994366 + 489 WP_002294196.1 mannosyl-glycoprotein endo-beta-N-acetylglucosamidase -
L1881_RS09750 (L1881_09750) 1994908..1995561 - 654 WP_002317081.1 ABC transporter permease -
L1881_RS09755 (L1881_09755) 1995576..1996493 - 918 WP_002294193.1 osmoprotectant ABC transporter substrate-binding protein -
L1881_RS09760 (L1881_09760) 1996490..1997131 - 642 WP_002293405.1 ABC transporter permease -
L1881_RS09765 (L1881_09765) 1997135..1998310 - 1176 WP_002294192.1 betaine/proline/choline family ABC transporter ATP-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin YoeB

(22-87)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(5-69)


Sequences

Toxin        


Download         Length: 89 a.a.        Molecular weight: 10646.11 Da        Isoelectric Point: 9.9931

>T232728 WP_002294198.1 NZ_CP091100:1993411-1993677 [Enterococcus faecium]
MSNYTVAIKNSAKVDLRKIKQSNLKKQFEEVIQTLKEDPYMPTQSFEKLRPTHEGRYSRRLNRQHRVVYKVDEENKVVEI
YSAWTHYE

Download         Length: 267 bp

>T232728 NZ_CP128191:c3071587-3071485 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin


Download         Length: 88 a.a.        Molecular weight: 10016.03 Da        Isoelectric Point: 4.1207

>AT232728 WP_002294199.1 NZ_CP091100:1993148-1993411 [Enterococcus faecium]
MANTTMNPSTARKNFYQLLKEVNENHTEIEIISDRSGNNAVLIGLEDWRAIQETLFLEQTGTLDKVRDREKDDSGFTNID
DIDWEAL

Download         Length: 264 bp

>AT232728 NZ_CP128191:3071478-3071623 [Klebsiella pneumoniae]
TAAAGATAAAAAGAGACCGAATACGATTCCTGTATTCGGTCCAGGGAAATGGCTCTTGGGAGAGAGCCGTGCGCTAAAAG
TTGGCATTAATGCAGGCTAAGTCGCCTTGCACTATAAGAATAGTTTAACGCGTCAGCTTTTCCAGT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A829FMA0

Antitoxin

Source ID Structure
AlphaFold DB A0A828ZU84

References