Detailed information of TA system TA232724

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): hipBA/HipA-HipB
• Location: 1170331..1171892
• Replicon: chromosome
• Accession: NZ_CP091099
• Organism: Pantoea agglomerans strain Pa58

Toxin (Protein)

• Gene name: hipA
• Uniprot ID: A0A8X8J3D8
• Locus tag: LZ609_RS09030
• Protein ID: WP_022625645.1
• Coordinates: 1170579..1171892 (+)
• Length: 438 a.a.

Antitoxin (Protein)

• Gene name: hipB
• Uniprot ID: -
• Locus tag: LZ609_RS09025
• Protein ID: WP_010244879.1
• Coordinates: 1170331..1170579 (+)
• Length: 83 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ609_RS09005 (LZ609_09005)	1165578..1167803	+	2226	WP_245116548.1	iron ABC transporter permease	-
LZ609_RS09010 (LZ609_09010)	1167800..1168861	+	1062	WP_245116550.1	ABC transporter ATP-binding protein	-
LZ609_RS09015 (LZ609_09015)	1168885..1169679	+	795	WP_022625642.1	inositol monophosphatase family protein	-
LZ609_RS09020 (LZ609_09020)	1169713..1170150	-	438	WP_111533813.1	GNAT family N-acetyltransferase	-
LZ609_RS09025 (LZ609_09025)	1170331..1170579	+	249	WP_010244879.1	type II toxin-antitoxin system antitoxin HipB	Antitoxin
LZ609_RS09030 (LZ609_09030)	1170579..1171892	+	1314	WP_022625645.1	type II toxin-antitoxin system HipA family toxin	Toxin
LZ609_RS09035 (LZ609_09035)	1172030..1172203	+	174	WP_230873490.1	type II toxin-antitoxin system MqsA family antitoxin	-
LZ609_RS09040 (LZ609_09040)	1172380..1173801	+	1422	WP_245116552.1	M24 family metallopeptidase	-
LZ609_RS09045 (LZ609_09045)	1173877..1175922	+	2046	WP_010244891.1	FUSC family protein	-
LZ609_RS09050 (LZ609_09050)	1176397..1176837	-	441	WP_122458470.1	TIR domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• HipA, N-terminal subdomain 1 (6-100)

Antitoxin

• Cro/C1-type helix-turn-helix domain (9-54)

Sequences

Toxin

Protein

• Length: 438 a.a.
• Molecular weight: 49147.73 Da
• Isoelectric Point: 8.4280

>T232724 WP_022625645.1 NZ_CP091099:1170579-1171892 [Pantoea agglomerans]
MQRLIAWMNGERVGVLTRQRNGAHEFQYDTGWLSNPLSRPLSLSMPLQVKALTSHAVINFFDNLLPDSPLIRDRIVARYQ
IKSRQPFDLLQEVGRDSVGATMLLPPDMPLPALQARYEVLDETRLESVLSAYQSDIPLGMLREETDFRISVAGAQEKTAL
LLTDEGWSIPAGATPTSHIIKLPIGEIKQPAATLDMRESVENEYLCLALARALGIDVPQATIIRAGQMRALAVERFDRRW
SRDKTRLIRLPQEDFCQALGLPSSTKYESDGGPGIAEIMQILMGSSNAIEDRYRFMMFQVFQWLIGATDGHAKNFSLFIE
RGGSYRLTPFYDVISAYPVLGGTGLNKRALKLAMGLRATKGKKTEIDKIFPRHFIATAKSVSFDRDSLQQIFDFFIKAFP
QAVVSVRDALPPDFPQHIADAIFSHSLIMLERLRHKE

Nucleotide

• Length: 1314 bp

>T232724 NZ_CP128191:389782-390129 [Klebsiella pneumoniae]
ATGTGGGATGTAGAAACGACGGATACGTTTGATGCCTGGTTCGAATTACAAAGTAGAGCTTTAAAAGAGGATATGTTGGC
CACGATGCTCATCCTGTCTGAGTTTGCTCCGCAGCTTGGGCGCCCGTATGTTGATACGGTGAAAGATTCAACGTTTCAGA
ATATGAAAGAACTGCGGGTTCAGCATCATGGGCTCCCCATCCGCGCCTGTTTTGCTTTTGATCCTCTGCGGAAAGCTATC
GTTTTATGTGTGGGCAATAAGGATGGCATGAATGAGAAACGTTTTTACAAAGAGATGATTACTCTGGCTGACAGAGAATT
CAGCCAACACCTGACTAAGGAGCGATAA

Antitoxin

Protein

• Length: 83 a.a.
• Molecular weight: 9333.58 Da
• Isoelectric Point: 5.0775

>AT232724 WP_010244879.1 NZ_CP091099:1170331-1170579 [Pantoea agglomerans]
MIYSPLQLANRLKLIRQRNGWTQSELAKKVGLKQATISHFENAPDSTSLATLFKLLQSLELSLEVQEKEEAGAPQLHDED
EW

Nucleotide

• Length: 249 bp

>AT232724 NZ_CP128191:390129-390428 [Klebsiella pneumoniae]
ATGGCCACGCTAAAAGAACTCATGGCGAAACAGAGTCCTGATAGCCAGCAGCGTATTGCAGCGAAAGCGGCAGAGATACG
CCAGTCTGTCGCTTTAAACTTGCTTCGAGAAGAGTTGCAAATGTCGCAAACAGAGATGGCTGCGGCTATGGGGGTAAAGC
AGCCAACGATCGCTAAAATGGAACAGGCTGATAACGACCCTCGGCTTTCGACCCTAAAACGCTACATTGCGGCATTGGGG
GGAGAACTCAGTATAAATGTCACATTGCCGACTGGAAAAAAAGTCTCGTTTAATTTGTGA