Detailed information of TA system TA232720

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-RelB
• Location: 164662..165188
• Replicon: plasmid p2
• Accession: NZ_CP091098
• Organism: Pantoea agglomerans strain Pa58

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: LZ609_RS03355
• Protein ID: WP_122459952.1
• Coordinates: 164901..165188 (+)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A8X8DPB7
• Locus tag: LZ609_RS03350
• Protein ID: WP_010257033.1
• Coordinates: 164662..164901 (+)
• Length: 80 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ609_RS03335 (LZ609_03335)	160637..161158	+	522	WP_022624256.1	DUF2268 domain-containing putative Zn-dependent protease	-
LZ609_RS03340 (LZ609_03340)	161208..162224	-	1017	WP_010257039.1	NAD(P)-dependent alcohol dehydrogenase	-
LZ609_RS03345 (LZ609_03345)	162329..164302	-	1974	WP_122459953.1	methyl-accepting chemotaxis protein	-
LZ609_RS03350 (LZ609_03350)	164662..164901	+	240	WP_010257033.1	type II toxin-antitoxin system RelB/DinJ family antitoxin	Antitoxin
LZ609_RS03355 (LZ609_03355)	164901..165188	+	288	WP_122459952.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ609_RS03360 (LZ609_03360)	165233..165529	-	297	WP_033770131.1	hypothetical protein	-
LZ609_RS03365 (LZ609_03365)	165731..165907	+	177	WP_010257023.1	KGG domain-containing protein	-
LZ609_RS03370 (LZ609_03370)	165971..166867	-	897	WP_010257019.1	LysR family transcriptional regulator	-
LZ609_RS03375 (LZ609_03375)	167070..168194	+	1125	WP_122459951.1	MFS transporter	-
LZ609_RS03380 (LZ609_03380)	168263..169288	+	1026	WP_122459950.1	alpha/beta hydrolase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..206494	206494

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Antitoxin

• RelB antitoxin/Antitoxin DinJ (1-77)

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 10998.88 Da
• Isoelectric Point: 10.2573

>T232720 WP_122459952.1 NZ_CP091098:164901-165188 [Pantoea agglomerans]
MTWQLEFDQRALKEWRKLGPTVREQLKKKLAECLESPRIEANKLSGIPDCYKIKLKSSGYRLVYQVIDDRVVVFVVAVGK
RERSEVCSAASRRLS

Nucleotide

• Length: 288 bp

>T232720 NZ_CP128185:c2881833-2881543 [Aliiglaciecola sp. LCG003]
ATGGCTAGTTACCGTCTTGCTCCATTGGCCGAGCTGGATATGGAAGCAATTGGGGAATACTCTTTTGAACAATGGGGTAT
CAATCAAGCTAACTATTATGCTGATGAACTTGTTTTAGCTTTTGAAGGTTTGGCAGAGTCTCCTTGTTTGGGGGTATCCT
GTGACAATGTTCGGGTAGGCTATAAATTTTATCGCCAAGGCAAGCACTTGATTTATTTTAAAACAACCGATTATGGTGTG
GCGGTTATAAGAATACTGCATGAGCGAATGTCACCCAGTCTCTTTCTTTAA

Antitoxin

Protein

• Length: 80 a.a.
• Molecular weight: 9002.33 Da
• Isoelectric Point: 4.3410

>AT232720 WP_010257033.1 NZ_CP091098:164662-164901 [Pantoea agglomerans]
MGTINIRIDDDLKTRSYAALEKMGVTPSDALRLMLEYIADNERLPFKQTLLSDEDAALVDIVKERLRNPEPVRVTLDDL

Nucleotide

• Length: 240 bp

>AT232720 NZ_CP128185:c2882071-2881826 [Aliiglaciecola sp. LCG003]
ATGTCAACAATCCGAAAAACTATTACTGTTACAGATCAACAAGACGAATGGATAAAAGCCCAAATTGTTGCTGGCCGATA
CACCAACGATAGCGAATATATCCGTGCTCTGGTACGTAACGATCAGGAGCAAAATAGCCATGATGGCGCTATAAGAAAAG
CCTTAATTGAAGGTGAGGCAAGTGGAAAGCCACAGCCATTCGAGGTAGGTGCTTTTAAAGCAAGAATGATGGCTAAACAT
GGCTAG