Detailed information of TA system TA023272

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): vapBC/VapC-VagC
• Location: 1164187..1164866
• Replicon: chromosome
• Accession: NC_011662
• Organism: Thauera sp. MZ1T

Toxin (Protein)

• Gene name: VapC1
• Uniprot ID: C4ZJ92
• Locus tag: TMZ1T_RS05210
• Protein ID: WP_012584823.1
• Coordinates: 1164187..1164606 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: VapB1
• Uniprot ID: C4ZJ93
• Locus tag: TMZ1T_RS05215
• Protein ID: WP_012584824.1
• Coordinates: 1164603..1164866 (-)
• Length: 88 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
TMZ1T_RS05185	1160373..1160888	+	516	WP_187283037.1	DUF3833 domain-containing protein	-
TMZ1T_RS05190	1160885..1161787	+	903	WP_012584820.1	SDR family NAD(P)-dependent oxidoreductase	-
TMZ1T_RS05195	1161880..1162278	+	399	WP_086014422.1	nuclear transport factor 2 family protein	-
TMZ1T_RS05200	1162581..1163186	+	606	WP_004303907.1	SCO family protein	-
TMZ1T_RS05205	1163250..1164101	-	852	WP_012584822.1	RNA polymerase sigma factor RpoH	-
TMZ1T_RS05210	1164187..1164606	-	420	WP_012584823.1	type II toxin-antitoxin system VapC family toxin	Toxin
TMZ1T_RS05215	1164603..1164866	-	264	WP_012584824.1	AbrB/MazE/SpoVT family DNA-binding domain-containing protein	Antitoxin
TMZ1T_RS05220	1165008..1165418	-	411	WP_012584825.1	putative toxin-antitoxin system toxin component, PIN family	-
TMZ1T_RS05225	1165411..1165659	-	249	WP_004303917.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
TMZ1T_RS05230	1165792..1166058	+	267	WP_187283026.1	type II toxin-antitoxin system Phd/YefM family antitoxin	-
TMZ1T_RS05235	1166055..1166456	+	402	WP_012584827.1	type II toxin-antitoxin system VapC family toxin	-
TMZ1T_RS05240	1166630..1167748	+	1119	WP_012584828.1	porin	-
TMZ1T_RS05245	1167994..1169484	+	1491	WP_012584829.1	IS21 family transposase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1169477..1170274	797

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• PIN domain (3-127)

Antitoxin

• SpoVT-AbrB domain (11-38)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15734.98 Da
• Isoelectric Point: 6.4614

>T23272 WP_012584823.1 NC_011662:c1164606-1164187 [Thauera sp. MZ1T]
VIYLLDTNILIYLIKNQPPSIAQRIDALPDSDTLCMSFVTWAELLKGAERSTRKTEVLRRLNSLARQIPVRYPADPAICR
RYAEQATRLKEAGTPIGANDLWIACHALAEDATVVTHNTREFRRIAGLRVEDWVSSDED

Nucleotide

• Length: 420 bp

>T23272 NC_011662:c1164606-1164187 [Thauera sp. MZ1T]
GTGATCTACCTGCTCGACACCAATATCCTGATCTACCTGATCAAGAACCAGCCGCCCAGCATCGCGCAGCGCATCGACGC
ACTTCCTGATAGCGACACCCTGTGCATGTCTTTCGTGACCTGGGCAGAGTTGTTGAAGGGCGCCGAGCGCAGCACCCGCA
AGACGGAGGTGCTGCGGCGGCTGAACTCCCTGGCGCGCCAGATACCGGTGCGCTATCCCGCCGACCCAGCCATCTGCCGG
CGTTACGCGGAACAGGCCACCCGCCTCAAGGAGGCCGGCACACCGATCGGCGCAAACGACCTGTGGATCGCCTGCCATGC
ACTGGCCGAAGACGCCACCGTGGTCACCCACAATACGCGCGAGTTCAGGCGCATTGCTGGTTTGCGCGTCGAGGACTGGG
TGTCCTCCGACGAGGACTGA

Antitoxin

Protein

• Length: 88 a.a.
• Molecular weight: 9611.83 Da
• Isoelectric Point: 4.4678

>AT23272 WP_012584824.1 NC_011662:c1164866-1164603 [Thauera sp. MZ1T]
METLPSRVFNNGNSQAVRIPAEFRLDTDRVSITRNDAGDLVIHPLRVQRGTALMQALKALGEVDDDFVGALEAEREAPLP
VQEREAL

Nucleotide

• Length: 264 bp

>AT23272 NC_011662:c1164866-1164603 [Thauera sp. MZ1T]
ATGGAAACACTGCCCAGCCGCGTCTTCAACAACGGCAACAGCCAGGCGGTCCGCATCCCGGCAGAGTTCCGCCTCGATAC
CGACCGCGTCAGCATCACGCGCAACGACGCGGGCGACCTGGTGATCCACCCCTTGCGGGTACAGCGTGGCACCGCGCTGA
TGCAGGCCCTGAAAGCGCTGGGCGAAGTGGACGACGACTTCGTCGGCGCACTCGAGGCCGAGCGGGAAGCGCCGCTGCCG
GTGCAGGAGCGCGAGGCGCTGTGA

Structures

Toxin

• AlphaFold DB: C4ZJ92

Antitoxin

• AlphaFold DB: C4ZJ93