Detailed information of TA system TA232719

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/ParE-YafN
• Location: 129319..129854
• Replicon: plasmid p2
• Accession: NZ_CP091098
• Organism: Pantoea agglomerans strain Pa58

Toxin (Protein)

• Gene name: relE
• Uniprot ID: A0A8X8DPA1
• Locus tag: LZ609_RS03195
• Protein ID: WP_010257115.1
• Coordinates: 129319..129606 (-)
• Length: 96 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A379LU84
• Locus tag: LZ609_RS03200
• Protein ID: WP_022624281.1
• Coordinates: 129603..129854 (-)
• Length: 84 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZ609_RS03160 (LZ609_03160)	125212..126879	+	1668	WP_245115320.1	lipid IV(A) 4-amino-4-deoxy-L-arabinosyltransferase	-
LZ609_RS03165 (LZ609_03165)	126879..127199	+	321	WP_010257131.1	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnE	-
LZ609_RS03170 (LZ609_03170)	127196..127561	+	366	WP_010257128.1	4-amino-4-deoxy-L-arabinose-phosphoundecaprenol flippase subunit ArnF	-
LZ609_RS03175 (LZ609_03175)	127666..127857	-	192	WP_233267992.1	hypothetical protein	-
LZ609_RS03180 (LZ609_03180)	128035..128310	+	276	Protein_102	SAM-dependent DNA methyltransferase	-
LZ609_RS03185 (LZ609_03185)	128430..128762	+	333	WP_031292300.1	type II toxin-antitoxin system RelE/ParE family toxin	-
LZ609_RS03190 (LZ609_03190)	128759..129049	+	291	WP_022624282.1	XRE family transcriptional regulator	-
LZ609_RS03195 (LZ609_03195)	129319..129606	-	288	WP_010257115.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
LZ609_RS03200 (LZ609_03200)	129603..129854	-	252	WP_022624281.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
LZ609_RS03205 (LZ609_03205)	129995..131647	-	1653	WP_245115322.1	intermembrane transport protein PqiB	-
LZ609_RS03210 (LZ609_03210)	132242..132568	+	327	WP_245115324.1	DUF3302 domain-containing protein	-
LZ609_RS03215 (LZ609_03215)	132570..133706	+	1137	WP_033786324.1	HlyD family secretion protein	-
LZ609_RS03220 (LZ609_03220)	133982..134251	+	270	WP_163852381.1	DUF1471 family periplasmic protein YahO	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Mobilizable plasmid	-	-	1..206494	206494

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-86)

Antitoxin

No domain identified.

Sequences

Toxin

Protein

• Length: 96 a.a.
• Molecular weight: 11173.08 Da
• Isoelectric Point: 10.3856

>T232719 WP_010257115.1 NZ_CP091098:c129606-129319 [Pantoea agglomerans]
VSYTVKFREEAFKEWQKLDKSLQQQFAKKLKKCCDNPHIPSARLRGIKDCYKIKLRASGFRLVYQVIDDQLVIAVVAVGK
RERSDVYHLASERMR

Nucleotide

• Length: 288 bp

>T232719 NZ_CP128184:c2061131-2060781 [Bacillus velezensis]
TTGATTGTAAAGCGCGGCGATGTTTATTTTGCTGATTTATCTCCTGTTGTTGGCTCAGAGCAAGGCGGCGTACGCCCGGT
TTTAGTGATCCAAAATGATATCGGAAATCGCTTTAGCCCGACTGCTATTGTTGCAGCCATAACAGCCCAAATACAGAAAG
CGAAATTACCAACCCACGTCGAAATTGATGCAAAACGCTACGGTTTTGAAAGAGATTCCGTTATTTTGCTGGAGCAAATT
CGGACGATTGACAAGCAAAGATTAACGGATAAAATAACTCATCTGGATGATGAAATGATGGATAAGGTTGATGAAGCCTT
GCAAATCAGTTTGGCACTCATTGATTTTTAG

Antitoxin

Protein

• Length: 84 a.a.
• Molecular weight: 9081.35 Da
• Isoelectric Point: 3.9507

>AT232719 WP_022624281.1 NZ_CP091098:c129854-129603 [Pantoea agglomerans]
MPNIILSDTSASVSELKKNPMATVSAGDGYPVAILNRNQPAFYCVPAELYEQMLDALDDQELVKLVSERSGQRLLDVDLD
ALL

Nucleotide

• Length: 252 bp

>AT232719 NZ_CP128184:c2061418-2061137 [Bacillus velezensis]
TTGTCTGAATCCAGCGCAAGAACCGAAATGAAAATCAGCTTGCCTGAAAACTTAGTAGCTGAATTGGATGGTGTAGCGAT
GCGGGAGAAACGAAGCAGAAACGAACTGATATCACAAGCAGTGAGAGCGTATGTCAGCGAACGGACAACTCGCCATAACC
GTGATTTGATGAGACGCGGGTATATGGAAATGGCGAAAATCAACTTGAATATCTCTTCTGAGGCTCACTATGCTGAGTGC
GAAGCAGAAACGACCGTTGAGCGCTTAGTCAGCGGAGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A379LU84