Detailed information of TA system TA232716

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): PanAT/Fic-DUF4065
• Location: 748586..749616
• Replicon: chromosome
• Accession: NZ_CP091095
• Organism: Corynebacterium diphtheriae strain CD1009

Toxin (Protein)

• Gene name: panT
• Uniprot ID: -
• Locus tag: FE377_RS03690
• Protein ID: WP_199323424.1
• Coordinates: 748586..749005 (-)
• Length: 140 a.a.

Antitoxin (Protein)

• Gene name: panA
• Uniprot ID: -
• Locus tag: FE377_RS03695
• Protein ID: WP_235697112.1
• Coordinates: 749050..749616 (-)
• Length: 189 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
FE377_RS03675 (FE377_03675)	745244..746098	+	855	WP_010934561.1	hypothetical protein	-
FE377_RS03680 (FE377_03680)	746091..746999	-	909	WP_085666276.1	DUF1906 domain-containing protein	-
FE377_RS03685 (FE377_03685)	747128..748327	-	1200	WP_196978537.1	cation:proton antiporter	-
FE377_RS03690 (FE377_03690)	748586..749005	-	420	WP_199323424.1	type II toxin-antitoxin system death-on-curing family toxin	Toxin
FE377_RS03695 (FE377_03695)	749050..749616	-	567	WP_235697112.1	Panacea domain-containing protein	Antitoxin
FE377_RS03700 (FE377_03700)	749868..750071	-	204	WP_016829450.1	hypothetical protein	-
FE377_RS03710 (FE377_03710)	750895..751170	+	276	WP_014303127.1	hypothetical protein	-
FE377_RS03715 (FE377_03715)	751177..751929	+	753	WP_014306660.1	precorrin-6A synthase (deacetylating)	-
FE377_RS03720 (FE377_03720)	751948..752205	-	258	WP_010934589.1	mycoredoxin	-
FE377_RS03725 (FE377_03725)	752226..752729	-	504	WP_014317722.1	dihydrofolate reductase	-
FE377_RS03730 (FE377_03730)	752729..753541	-	813	WP_014317723.1	thymidylate synthase	-
FE377_RS03735 (FE377_03735)	753635..754393	-	759	WP_010934592.1	3'(2'),5'-bisphosphate nucleotidase CysQ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	748586..759246	10660

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (10-93)

Antitoxin

• Antitoxin SocA-like, Panacea domain (23-116)

Sequences

Toxin

Protein

• Length: 140 a.a.
• Molecular weight: 15548.73 Da
• Isoelectric Point: 8.7021

>T232716 WP_199323424.1 NZ_CP091095:c749005-748586 [Corynebacterium diphtheriae]
MVKKLVYLSCTLNQKCGQRTGPHREPEPFLGFSVRDRSGLEGAIASVFQSSFDVLLYPTIYDQAAALLFKLANGHYFQDG
NKRTAFHLCLAYLRANNVHVSPPRSDDVITLLQTTVSRSGSQENGIAFVRQKLLDWTVD

Nucleotide

• Length: 420 bp

>T232716 NZ_CP128182:266071-266376 [Stenotrophomonas maltophilia]
ATGAAGATCCAGCGTACCCGTCAGTTCGCGACATGGATTGACGCTCTCAAGGACGTAACCGCACGCGCTCGCATCCTGGC
CCGTATCGGTCGGCTCGCTGAAGGCCATCCTGGTGATCACCGCTATCTGGCGGATGGCGTTTCTGAATTGCGTATCGATG
CAGGACCCGGTTACCGCGTGTACTACACCCAGCGGGGCAGGCAGTTGGTGATTCTTCTGGTCGGAGGCGACAAGGGTTCG
CAACAGCGCGATATAGAGAAGGCCAAGGAGATTGCGCGTGCCCTGCGAGCATCGAACTGGTTGTAG

Antitoxin

Protein

• Length: 189 a.a.
• Molecular weight: 20962.38 Da
• Isoelectric Point: 4.6309

>AT232716 WP_235697112.1 NZ_CP091095:c749616-749050 [Corynebacterium diphtheriae]
MISIHDVAARVLELHPSCDKMKLYKLCYFSQGWHLAWTGRPLFNEELQAWKYGAVSPTLRQASELRADDDRRVTQIWSGD
SSQLTDYERSVVDTVVSFYGDLGSFHLSDLSHGFAWSTVRGDLPPDASCSDVIPHSLIRREFVENAWGEAPTPNAPSHLP
STALDSLEQAADDVAAENAETLRLLAFI

Nucleotide

• Length: 567 bp

>AT232716 NZ_CP128182:266417-266719 [Stenotrophomonas maltophilia]
ATGGCTATCAAGAAGAAAGTTGAACTCGAAGCATTTGATGTGGCCGAACACCTTCATACACCGAAGGAAATGGCGGCCTA
TCTCGATGCATGCATCGAAGAAAGCGACGGCGATTCGGCATTCATCGCCAAGGCGCTGGGCGATATCGCGCGTGCCCAAG
GGATGAGCAAGGTCGCACGTGCGGCGGGCCTGTCGCGGGAGAGTCTGTATCGTGCCCTGTCTGGCGAGCGCAGCCCTGAT
TTCTCGACCATCCTGAAGGTGACTCGTGCCCTGGGTGTGCGCCTGCATGCCAGCGCTGCATGA