Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) hicAB/HicA-HicA
Location 414273..414676 Replicon chromosome
Accession NZ_CP091092
Organism Methanomicrobium antiquum strain DSM 21220

Toxin (Protein)


Gene name hicA Uniprot ID -
Locus tag L1994_RS01990 Protein ID WP_278100025.1
Coordinates 414273..414467 (+) Length 65 a.a.

Antitoxin (Protein)


Gene name hicB Uniprot ID -
Locus tag L1994_RS01995 Protein ID WP_278100787.1
Coordinates 414467..414676 (+) Length 70 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1994_RS01960 (L1994_01960) 410517..410906 + 390 WP_278100019.1 Fic family protein -
L1994_RS01965 (L1994_01965) 410907..411170 - 264 WP_278100020.1 hypothetical protein -
L1994_RS01970 (L1994_01970) 411173..412297 - 1125 WP_278100021.1 hypothetical protein -
L1994_RS01975 (L1994_01975) 412412..412915 - 504 WP_278100022.1 hypothetical protein -
L1994_RS01980 (L1994_01980) 413103..413333 + 231 WP_278100023.1 hypothetical protein -
L1994_RS01985 (L1994_01985) 413401..413949 - 549 WP_278100024.1 hypothetical protein -
L1994_RS01990 (L1994_01990) 414273..414467 + 195 WP_278100025.1 type II toxin-antitoxin system HicA family toxin Toxin
L1994_RS01995 (L1994_01995) 414467..414676 + 210 WP_278100787.1 type II toxin-antitoxin system HicB family antitoxin Antitoxin
L1994_RS02000 (L1994_02000) 414942..415208 - 267 WP_278100026.1 NAC family transcription factor -
L1994_RS02005 (L1994_02005) 415211..415561 - 351 WP_278100788.1 cupin domain-containing protein -
L1994_RS02010 (L1994_02010) 415598..417211 - 1614 WP_278100027.1 hydroxylamine reductase -
L1994_RS02015 (L1994_02015) 417297..417656 + 360 WP_278100028.1 helix-turn-helix domain-containing protein -
L1994_RS02020 (L1994_02020) 417956..418213 - 258 WP_278100029.1 MTH865 family protein -
L1994_RS02025 (L1994_02025) 418210..418428 - 219 WP_278100030.1 hypothetical protein -
L1994_RS02030 (L1994_02030) 418516..419265 + 750 WP_278100031.1 winged helix-turn-helix domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

HicA mRNA interferase family

(4-60)

Antitoxin

HicB-like antitoxin of toxin-antitoxin system

(5-62)


Sequences

Toxin        


Download         Length: 65 a.a.        Molecular weight: 7099.25 Da        Isoelectric Point: 11.0643

>T232715 WP_278100025.1 NZ_CP091092:414273-414467 [Methanomicrobium antiquum]
MKVRDVIKLLEKEGWQLVAVRGSHRQYKNPDAAGRITVPGSMNDSLAPGTLNSILKQAGIKERR

Download         Length: 195 bp

>T232715 NZ_CP128182:c105888-104566 [Stenotrophomonas maltophilia]
ATGGGTACGCTGCAGGTCTGGATGAATGGTGTGGAAGTCGCACTTTGGGATGATGTCCGGAACGGGTCATCCCGGTTGTC
GTATGTCAGCCAGTGGATCAGCTCGCCCCAGTCCCGACCGTTGTCGCTCTCTCTACCCCTGCTCCCAGATGGCGAGAGCC
ATCGGGGCAACGTCGTCAACGACTACTTCGATAACCTTCTTCCCGATAACGTCGCCATACGCAACCGGATCCGCGACCGG
TTCGCCACGCGCGGCAGCGATACGTTCGATCTTCTTGAAGCCATTGGACGGGATTGTGTCGGCGCAGTGCAGCTGTTGCC
GCCTGCGCATCCACCCGAAGACATCCAGCAGATCACGTGCGAGGTGTTGGACGAAGCAGGTGTCGCTACGATCCTGCGTC
AGGTGACGACAGGGAACCTGCCTGGCGCACCCAGCCGTGATGATGCATTCCGCATTTCCATCGCCGGTGCGCAGGAAAAG
ACCGGTCTTCTGCTGCATGCTGGCCAATGGTGCATTCCTACCGGCAACACACCATCCACTCACATCTTCAAGCTGCCGCT
TGGCATTGTTGGCAACATGCGGGCAGACATGCATCAGTCCGTGGAGAATGAATGGCTGTGCATGCATCTGCTTTCCGCCT
TTGATATCCCCGTGGCCGAGACGCAGATGGGCCGCTTCAACGACCAACGTGCTCTCATTGTCGAGCGGTTTGACCGTCGC
CTGTCTGCCGACCGCCGGTGGTGGCTGCGACTGCCACAGGAAGACATGTGTCAGGTCTTTGGTCTGCCGGCTGCCAGAAA
GTATGAATCCGATGGCGGCCCCGGTATCGTTCCGATCATGGATCTGCTTCGACAGTCCGAACACCCCGAGGATCGCGCGA
TCTTCTTCAAGACGCAGATTCTTTTCTGGATGCTGGCCGCAACCGACGGCCATGCCAAGAATTTCAGTGTTCACCTGGAA
GCCGGTGGACGCTTCCGCCTGACGCCCGTCTACGACGTGCTGTCGGTATATCCCATCCTCGGCTGGGGACCCAATCAACT
CGATCCACGAAACGCACAGCTCGCCATGGCCGTACATGGCAAGAACCGCCACCGGAAACTGCACCTTGTGCGACGGCGGC
ACTGGAATGAAACCGCGCGCGCCTGCGGCGTTGCCGATGGTGCAGAACCATGGATCAAGACATTGATCGCGGCCGTCGAG
CCCGCCATCCAGCAGGTCACCCGTCAGCTCCCGGATGACTTCCCCTCAAACGTGTCCGAACCGATTTTCAACGGACTTCG
TGCTGCGGCAGCACGCCTTTCCAGCATGGCCCCCGAGGCTTGA

Antitoxin


Download         Length: 70 a.a.        Molecular weight: 7680.75 Da        Isoelectric Point: 5.0360

>AT232715 WP_278100787.1 NZ_CP091092:414467-414676 [Methanomicrobium antiquum]
MFRFLIVVEKADSNYSAYSPDIPGCVATGKTREEAEKNMHEAIAFHIEGLKEDRLPIPEGKSSASWVLV

Download         Length: 210 bp

>AT232715 NZ_CP128182:c106149-105892 [Stenotrophomonas maltophilia]
ATGGACAGGCCGCTGCACACAGTGAGGACAGCCCAACAACTTGCGCCCCTGATGCGTGCTTTCCGGCGCCAGGCGGGCCT
GAGCCAGGCTCAGCTGGCGGAGCGACTCGGGATCAGCCGCCAGGCAGTGGGCGCGCTGGAACGCGACCCTGCATCGGCAA
GTTTTGAACGCCTGATGCGGATCTGGGCGGTGCTGGGTCTGGAGGTCAGCCTCCAGCAACGAAGTCCCCAGGAGAACACG
TCGTCATTGGAGTGGTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Source ID Structure

References