Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) Hha-TomB/-
Location 3631624..3632244 Replicon chromosome
Accession NZ_CP091081
Organism Enterobacter roggenkampii strain GD21SC1505

Toxin (Protein)


Gene name Hha Uniprot ID A0A1H8SI38
Locus tag L1S38_RS17980 Protein ID WP_008499287.1
Coordinates 3632026..3632244 (+) Length 73 a.a.

Antitoxin (Protein)


Gene name TomB Uniprot ID V3PBI9
Locus tag L1S38_RS17975 Protein ID WP_008499288.1
Coordinates 3631624..3631998 (+) Length 125 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L1S38_RS17965 (L1S38_17965) 3626752..3627945 + 1194 WP_021241633.1 multidrug efflux RND transporter periplasmic adaptor subunit AcrA -
L1S38_RS17970 (L1S38_17970) 3627968..3631114 + 3147 WP_250670136.1 multidrug efflux RND transporter permease subunit AcrB -
L1S38_RS17975 (L1S38_17975) 3631624..3631998 + 375 WP_008499288.1 Hha toxicity modulator TomB Antitoxin
L1S38_RS17980 (L1S38_17980) 3632026..3632244 + 219 WP_008499287.1 HHA domain-containing protein Toxin
L1S38_RS17985 (L1S38_17985) 3632451..3633002 + 552 WP_008499286.1 maltose O-acetyltransferase -
L1S38_RS17990 (L1S38_17990) 3633120..3633587 + 468 WP_008499285.1 YlaC family protein -
L1S38_RS17995 (L1S38_17995) 3633559..3635019 - 1461 WP_059359545.1 PLP-dependent aminotransferase family protein -
L1S38_RS18000 (L1S38_18000) 3635121..3635831 + 711 WP_059359547.1 GNAT family protein -
L1S38_RS18005 (L1S38_18005) 3635828..3635968 - 141 WP_003859006.1 type B 50S ribosomal protein L36 -
L1S38_RS18010 (L1S38_18010) 3635971..3636231 - 261 WP_006176933.1 type B 50S ribosomal protein L31 -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Haemolysin expression modulating, HHA

(13-69)

Antitoxin

Biofilm formation regulator YbaJ

(1-114)


Sequences

Toxin        


Download         Length: 73 a.a.        Molecular weight: 8612.00 Da        Isoelectric Point: 8.9008

>T232712 WP_008499287.1 NZ_CP091081:3632026-3632244 [Enterobacter roggenkampii]
MSDKPLTKIDYLMRLRRCQSIDTLERVIEKNKYELSDNELAVFYSAADHRLAELTMNKLYDKIPTSVWKFVR

Download         Length: 219 bp

>T232712 NZ_CP128153:2430918-2431658 [Bacillus sp. DX3.1]
TTGACAGTCTCTAACATTCGAATTGGTCTATTTCTCCTCGTGGTAGCCTTTTTATTTCTCATTTTATTTTATTGGAAAAA
TGAAGAACTGTACGAAGAAAAAAAGCAGCTGATTCGGAAAACATGGTATGGTGTGTTTATTTCGACAGTCACTGTGTATT
TTATGGTAAAAGGAATTGATTTGACCCTCTGGAAAAACATATTAATGTTTGTGGCAATGGTAATTTTTGTTGACATCGCG
TTTATTTTAACACCGAATATTTCAGAAATATGGGGTGCTAAATTTAGCGATATTGGAAGGACTGTGCAATCAATTAAAAG
GTCTCTTATTGCTTCGAAAGCACGTGGAGAAATCTATACGACACTCATTCAAAACGTAAATCCAGCAGCATTTGGAAGGA
TGGAATGGCGAACAGAAGCAGAATACGCTGAAAGTTTAAATGCATTTCTAGATACTTATGCCGAAAAAATTGGAGCAAAG
GTCGTTGTATTTGTTGCTTCAGATGAATTAAACACAAACTTTCGCGGCGTACGTTCCCAATTTAGTATCATGTTACCACT
AGAACATATAGAAAAACTAAATGAACAGAAAGCAGTTCAAGTTGAAAATGTCGGGATCATCCCAGTGAAAATTTTAAAAG
ATGTCTTTATTGTAATTGACGGTCAAAAGAATAATTTACAAGATCGTGACTTTGAAAATGTATATAATTTAACGATTCAT
CATAGTTATTTTAGTAAGTAA

Antitoxin


Download         Length: 125 a.a.        Molecular weight: 14481.28 Da        Isoelectric Point: 4.8886

>AT232712 WP_008499288.1 NZ_CP091081:3631624-3631998 [Enterobacter roggenkampii]
MDEYSPKRHDIAQLKFLCESLYHDCLANLDESNHGWVNDPTSAINLQLNELIEHIATFALNYKIKYNEDNKLIEQIDEYL
DDTFMLFSSYGINAQDLQKWRKSGNRLFRCFVNVSRANPVSLSC

Download         Length: 375 bp

>AT232712 NZ_CP128153:2431783-2431911 [Bacillus sp. DX3.1]
GTGGAAAAACAATATGACAACGATTTTTTCAAAGAAGAGAAGGATGATGCGACGGATTTCTCTTTAATAAAAGGAGATAC
GATGCAGCAAGTAGAAGACTTAGAAGAAGAGTTAAAAAGAAAAGGATAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1H8SI38

Antitoxin

Source ID Structure
AlphaFold DB V3PBI9

References