Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) relBE/upstrm_HI1419-dnstrm_HI1420
Location 47379..47969 Replicon chromosome
Accession NC_011662
Organism Thauera sp. MZ1T

Toxin (Protein)


Gene name relE Uniprot ID A0A0C3MT89
Locus tag TMZ1T_RS00170 Protein ID WP_041589583.1
Coordinates 47670..47969 (-) Length 100 a.a.

Antitoxin (Protein)


Gene name relB Uniprot ID C4ZIE8
Locus tag TMZ1T_RS00165 Protein ID WP_012584197.1
Coordinates 47379..47666 (-) Length 96 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
TMZ1T_RS20365 43058..43183 + 126 Protein_33 tyrosine-type recombinase/integrase -
TMZ1T_RS00145 43738..44010 + 273 WP_012584193.1 CopG family transcriptional regulator -
TMZ1T_RS20920 44211..44603 - 393 WP_144312128.1 hypothetical protein -
TMZ1T_RS00150 44617..45192 - 576 WP_012584194.1 hypothetical protein -
TMZ1T_RS20185 45394..46305 + 912 WP_012584195.1 nucleotide-binding protein -
TMZ1T_RS00160 46522..46737 + 216 WP_012584196.1 hypothetical protein -
TMZ1T_RS00165 47379..47666 - 288 WP_012584197.1 putative addiction module antidote protein Antitoxin
TMZ1T_RS00170 47670..47969 - 300 WP_041589583.1 type II toxin-antitoxin system RelE/ParE family toxin Toxin
TMZ1T_RS00175 48124..48735 + 612 WP_012584199.1 hypothetical protein -
TMZ1T_RS00180 48732..49922 + 1191 WP_012584200.1 hypothetical protein -
TMZ1T_RS00185 50038..50280 + 243 WP_012584201.1 type II toxin-antitoxin system Phd/YefM family antitoxin -
TMZ1T_RS00190 50277..50540 + 264 WP_012584202.1 Txe/YoeB family addiction module toxin -
TMZ1T_RS00195 50666..50893 + 228 WP_012584203.1 DUF2281 domain-containing protein -
TMZ1T_RS00200 50890..51276 + 387 WP_012584204.1 type II toxin-antitoxin system VapC family toxin -
TMZ1T_RS00205 51312..52766 + 1455 WP_012584205.1 DUF3375 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Addiction module killer protein, predicted

(2-96)

Antitoxin

Uncharacterized protein HI1420

(3-90)


Sequences

Toxin        


Download         Length: 100 a.a.        Molecular weight: 11166.74 Da        Isoelectric Point: 9.5224

>T23271 WP_041589583.1 NC_011662:c47969-47670 [Thauera sp. MZ1T]
MNTFLRTDDFDAWLAGLKDNVARARIVHRIRSAEHGNLGDCEPVGEGVSEMRIHVGPGYRAYYTRRGAVIYLLLPGGEKS
SHKRDIKRAIEMARALDKE

Download         Length: 300 bp

>T23271 NC_011662:c47969-47670 [Thauera sp. MZ1T]
ATGAACACTTTCCTGCGCACCGACGATTTCGACGCCTGGCTTGCCGGCTTGAAAGACAACGTGGCTCGAGCCCGCATCGT
CCACCGTATCCGCTCTGCCGAGCATGGAAATCTTGGTGACTGTGAGCCGGTAGGCGAAGGCGTTTCGGAAATGCGCATCC
ACGTCGGCCCTGGGTATCGCGCTTACTACACGCGACGTGGGGCTGTGATCTATCTGCTTCTGCCGGGCGGGGAAAAGTCG
TCGCACAAGCGCGACATCAAACGTGCCATCGAGATGGCGCGGGCTTTGGACAAGGAGTGA

Antitoxin


Download         Length: 96 a.a.        Molecular weight: 10199.67 Da        Isoelectric Point: 6.4614

>AT23271 WP_012584197.1 NC_011662:c47666-47379 [Thauera sp. MZ1T]
MVKTASFDAADYLNDEQTIAEYLTAALEDPNPDVFLAAVRDVARARGMAQLAKDAGLGRESLYKALTPGAKPRYDTVLKL
LHALGVKITATPVHS

Download         Length: 288 bp

>AT23271 NC_011662:c47666-47379 [Thauera sp. MZ1T]
ATGGTCAAGACCGCCAGCTTTGATGCTGCCGATTACCTGAACGACGAGCAAACCATCGCGGAGTATCTGACGGCCGCCCT
GGAAGACCCAAACCCTGATGTGTTTCTCGCTGCCGTCCGCGACGTTGCGCGCGCCCGCGGCATGGCGCAACTCGCCAAGG
ATGCGGGTCTTGGCCGTGAGAGCCTGTACAAGGCGCTCACGCCCGGCGCGAAGCCTCGCTATGACACAGTGCTCAAGCTG
CTTCATGCTCTGGGCGTGAAGATCACCGCAACGCCAGTCCATTCTTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0C3MT89

Antitoxin

Source ID Structure
AlphaFold DB A0A0C3N9N4

References