Detailed information of TA system TA232701

Bioinformatically predicted

Overview

TA module

• Type: IV
• Classification (family/domain): cptAB/Cpta(toxin)
• Location: 847644..848301
• Replicon: chromosome
• Accession: NZ_CP091081
• Organism: Enterobacter roggenkampii strain GD21SC1505

Toxin (Protein)

• Gene name: cptA
• Uniprot ID: A0A1H8U0Q4
• Locus tag: L1S38_RS04170
• Protein ID: WP_021242050.1
• Coordinates: 847891..848301 (+)
• Length: 137 a.a.

Antitoxin (Protein)

• Gene name: cptB
• Uniprot ID: W7NX65
• Locus tag: L1S38_RS04165
• Protein ID: WP_006178375.1
• Coordinates: 847644..847910 (+)
• Length: 89 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1S38_RS04145 (L1S38_04145)	843078..844511	-	1434	WP_250670353.1	6-phospho-beta-glucosidase	-
L1S38_RS04150 (L1S38_04150)	844628..845359	-	732	WP_059359735.1	MurR/RpiR family transcriptional regulator	-
L1S38_RS04155 (L1S38_04155)	845625..846284	+	660	WP_032664328.1	hemolysin III family protein	-
L1S38_RS04160 (L1S38_04160)	846369..847349	-	981	WP_008499712.1	tRNA-modifying protein YgfZ	-
L1S38_RS04165 (L1S38_04165)	847644..847910	+	267	WP_006178375.1	FAD assembly factor SdhE	Antitoxin
L1S38_RS04170 (L1S38_04170)	847891..848301	+	411	WP_021242050.1	protein YgfX	Toxin
L1S38_RS04175 (L1S38_04175)	848308..848829	-	522	WP_023309099.1	flavodoxin FldB	-
L1S38_RS04180 (L1S38_04180)	848931..849827	+	897	WP_008499709.1	site-specific tyrosine recombinase XerD	-
L1S38_RS04185 (L1S38_04185)	849856..850569	+	714	WP_008499708.1	bifunctional protein-disulfide isomerase/oxidoreductase DsbC	-
L1S38_RS04190 (L1S38_04190)	850575..852308	+	1734	WP_059359737.1	single-stranded-DNA-specific exonuclease RecJ	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Inner membrane protein YgfX (3-132)

Antitoxin

• Flavinator of succinate dehydrogenase (7-79)

Sequences

Toxin

Protein

• Length: 137 a.a.
• Molecular weight: 16097.08 Da
• Isoelectric Point: 10.9468

>T232701 WP_021242050.1 NZ_CP091081:847891-848301 [Enterobacter roggenkampii]
VVLWQSDLRVSWRSQWMSLLLHGLVAAFVLLMPWPLSYTPLWLLLLSFVVFDSVRSQRRINARQGEIKLLMDSRLRWQGK
EWDILGMPWMLNCGMMLRLRKVDGGRCQHLWLAADSMDAAEWRDLRRMLLQQTTQG

Nucleotide

• Length: 411 bp

>T232701 NZ_CP128116:c1395410-1394664 [Bacillus halotolerans]
ATGCTTTTATTCTTTCAAATCATGGTCTGGTGCACTATGGCCGCTTTAGGCTTATACGTATACGCCACATGGCGGTTCGA
AGCGAAGGTCAAAGAAAAAATGTCCGCCATCCGAAAAACATGGTATTTGCTGTTTGTTTTGGGCGCCATGATATACTGGA
CATATGATCCCTCTTCCCTGTTCACAAACTGGGAACGGTATGTCATTGTCGCTGTCAGCTTTGCTTTAATTGACGCTTTT
ATCTTTTTGAGCGCTTATGTGAAAAAACTGGCCGGCAGTGAACTGGAAACAGACACAAGAGAAATTCTCGAAGAAAACAA
CGAAATGCTCCACATGTATCTCGATCGGCTGAAAACATACCAATATCTATTGAAAAACGAACCGATTCATGTTTATTATG
GAAGTATAGAAGCATATGCTGAAGGAATTGATAAACTGCTGAAAACCTATGCTGATAAAATGAATCTGACGGCCAGCCTT
TGTCACTATTCGACACAGTCTGATAAAGACCGGTTAACCGAGCACATGGAGGATCCCGCTGACGTGCAAACGAGGCTGGA
TCGAAAGGATGTCTATTACGACCAGTATGGAAAAGTAGTGCTCATTCCCTTTACAATTGAGACACAGAGCTATGTCATCA
AACTGACGTCTGACAGCATTGTAACGGAATTTGATTATTTGCTATTCACATCATTAACGAGCATATATGATTTGGTGCTG
CCAATTGAGGAGGAAGGTGAAGGATAA

Antitoxin

Protein

• Length: 89 a.a.
• Molecular weight: 10569.05 Da
• Isoelectric Point: 5.1340

>AT232701 WP_006178375.1 NZ_CP091081:847644-847910 [Enterobacter roggenkampii]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDDDKRLFVRLLESDDPDLFNWLMNHGKPADTELQRMVQLIQTRN
RERGPVAI

Nucleotide

• Length: 267 bp

>AT232701 NZ_CP128116:c1394664-1394494 [Bacillus halotolerans]
ATGGAAAACGCGTTTCAAAACGGATGCCATCCGCGGGCAAAGAAACCGTTTAAAATCCTGAAAAAACGTTCAACCACCAG
TGTCGCAAGCTATCAAGTCAGTCCGCACACAGCAAGAATCTTCAAAGAAAACGAACGGCTGATTGATGAGTATAAACGAA
AAAAAGCATGA

Structures

Toxin

• AlphaFold DB: A0A1H8U0Q4

Antitoxin

• AlphaFold DB: W7NX65