Detailed information of TA system TA232693

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): relBE/Phd(antitoxin)
• Location: 1988282..1988826
• Replicon: chromosome
• Accession: NZ_CP091075
• Organism: Xanthomonas arboricola pv. pruni strain T1

Toxin (Protein)

• Gene name: relE
• Uniprot ID: -
• Locus tag: K9U02_RS08420
• Protein ID: WP_228960823.1
• Coordinates: 1988557..1988826 (+)
• Length: 90 a.a.

Antitoxin (Protein)

• Gene name: relB
• Uniprot ID: A0A2N7V9L6
• Locus tag: K9U02_RS08415
• Protein ID: WP_016902922.1
• Coordinates: 1988282..1988539 (+)
• Length: 86 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K9U02_RS08400 (K9U02_08400)	1983391..1984899	-	1509	WP_043087410.1	ribonuclease H-like domain-containing protein	-
K9U02_RS08405 (K9U02_08405)	1984896..1987391	-	2496	WP_043087409.1	DEAD/DEAH box helicase	-
K9U02_RS08410 (K9U02_08410)	1987549..1988226	+	678	WP_237352955.1	hemolysin III family protein	-
K9U02_RS08415 (K9U02_08415)	1988282..1988539	+	258	WP_016902922.1	type II toxin-antitoxin system Phd/YefM family antitoxin	Antitoxin
K9U02_RS08420 (K9U02_08420)	1988557..1988826	+	270	WP_228960823.1	type II toxin-antitoxin system RelE/ParE family toxin	Toxin
K9U02_RS08425 (K9U02_08425)	1988945..1989466	-	522	WP_051633992.1	hypothetical protein	-
K9U02_RS08430 (K9U02_08430)	1989637..1989990	-	354	WP_081327586.1	helix-turn-helix domain-containing protein	-
K9U02_RS08435 (K9U02_08435)	1990023..1990229	+	207	WP_223571151.1	hypothetical protein	-
K9U02_RS08440 (K9U02_08440)	1990389..1991480	-	1092	WP_039511112.1	ATP-grasp fold amidoligase family protein	-
K9U02_RS08445 (K9U02_08445)	1991938..1992651	+	714	WP_039511101.1	hypothetical protein	-
K9U02_RS08450 (K9U02_08450)	1992662..1993555	-	894	WP_043087408.1	LysR family transcriptional regulator	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1988282..1999888	11606

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (2-80)

Antitoxin

• Type II toxin-antitoxin system, antitoxin Phd/YefM (1-73)

Sequences

Toxin

Protein

• Length: 90 a.a.
• Molecular weight: 10221.75 Da
• Isoelectric Point: 10.1539

>T232693 WP_228960823.1 NZ_CP091075:1988557-1988826 [Xanthomonas arboricola pv. pruni]
VADLDAIADYIALEDAAAAAALVRRVFAHVEQLAEHPESGSRPQELKRSRYRQIVEPPCRVFYRVDGQRVVVVHVMRSER
LLRKNRLSR

Nucleotide

• Length: 270 bp

>T232693 NZ_CP128107:248040-248390 [Bacillus cereus]
TTGATTGTAAAACGCGGCGACGTGTATTTTGCAGACCTTTCCCCAGTTGTTGGTTCTGAGCAAGGAGGCGTTCGTCCGGT
TCTTGTCATTCAAAATGACATCGGAAATCGTTTTAGTCCGACTGTGATTGTAGCGGCTATTACTGCACAGATTCAAAAAG
CGAAATTACCCACTCATGTGGAAATTGATGCGAAAAAGTATGGTTTTGAGAGAGATTCTGTTATTTTACTTGAGCAGATT
CGAACAATCGATAAGCAACGCTTAACGGACAAAATCACTCATTTGGATGAAGTGATGATGAGTCGTGTAGATGAAGCGTT
ACAAATTAGTTTAGGACTAATAGATTTTTAA

Antitoxin

Protein

• Length: 86 a.a.
• Molecular weight: 9704.23 Da
• Isoelectric Point: 8.6056

>AT232693 WP_016902922.1 NZ_CP091075:1988282-1988539 [Xanthomonas arboricola pv. pruni]
MRTELVTTLKRQATELLADVERDKEPILITQHGLPSAYLVDVASYERMQQRMAILEGIARGEMAVAEGRSLSHEQAKQRL
ARWLK

Nucleotide

• Length: 258 bp

>AT232693 NZ_CP128107:247748-248035 [Bacillus cereus]
GTGTCCGAATCAAGTGTAACTACTGAAATCGTGGTTCGGTTGCCAAAGCAAATGGTAACGGAATTGGACGGAATTGGAAA
ACAAGAGAATAAGAATCGCCATGAACTAATTTGCCAGGCAACACAACTGTTATTGCGTCAACATAAGACGAAGAAACGCT
ACCAACATGAATCAATGCGACGTGGGTACATTGAAATGGGAAAAATTAATCTTGGTATTGCATCTGAAGCTTTCTTAGCA
GAGTATGAAGCAGCTCATACAGTAGAACGCTTAGTTAGCGGGGGGTAA

Structures

Antitoxin

• AlphaFold DB: A0A2N7V9L6