Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type IV Classification (family/domain) cptAB/Cpta(toxin)
Location 880971..881625 Replicon chromosome
Accession NZ_CP091068
Organism Klebsiella pneumoniae strain WSCRKP

Toxin (Protein)


Gene name cptA Uniprot ID R4YHX2
Locus tag L0980_RS04410 Protein ID WP_004144731.1
Coordinates 881218..881625 (+) Length 136 a.a.

Antitoxin (Protein)


Gene name cptB Uniprot ID W8UQ37
Locus tag L0980_RS04405 Protein ID WP_002916312.1
Coordinates 880971..881237 (+) Length 89 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0980_RS04380 (L0980_04380) 876127..877560 - 1434 WP_002916322.1 6-phospho-beta-glucosidase BglA -
L0980_RS04385 (L0980_04385) 877679..878407 - 729 WP_002916321.1 MurR/RpiR family transcriptional regulator -
L0980_RS04390 (L0980_04390) 878457..878768 + 312 WP_002916319.1 N(4)-acetylcytidine aminohydrolase -
L0980_RS04395 (L0980_04395) 878932..879591 + 660 WP_002916317.1 hemolysin III family protein -
L0980_RS04400 (L0980_04400) 879742..880725 - 984 WP_002916313.1 tRNA-modifying protein YgfZ -
L0980_RS04405 (L0980_04405) 880971..881237 + 267 WP_002916312.1 FAD assembly factor SdhE Antitoxin
L0980_RS04410 (L0980_04410) 881218..881625 + 408 WP_004144731.1 protein YgfX Toxin
L0980_RS04415 (L0980_04415) 881632..882153 - 522 WP_002916308.1 flavodoxin FldB -
L0980_RS04420 (L0980_04420) 882254..883150 + 897 WP_004144729.1 site-specific tyrosine recombinase XerD -
L0980_RS04425 (L0980_04425) 883173..883886 + 714 WP_002916301.1 bifunctional protein-disulfide isomerase/oxidoreductase DsbC -
L0980_RS04430 (L0980_04430) 883892..885625 + 1734 WP_004151783.1 single-stranded-DNA-specific exonuclease RecJ -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Inner membrane protein YgfX

(3-131)

Antitoxin

Flavinator of succinate dehydrogenase

(7-79)


Sequences

Toxin        


Download         Length: 136 a.a.        Molecular weight: 15936.69 Da        Isoelectric Point: 11.4778

>T232666 WP_004144731.1 NZ_CP091068:881218-881625 [Klebsiella pneumoniae]
VVLWQSDLRISWRAQWFSLLLHGVVAALVLLVPWPLSYTPIWLLLSLVVFDCVRSQRRIHARRGEIKLLTDSRLRWQNAE
WEILGTPWVINSGMLLRLRHVDTRRGQHLWLAADSMDAGEWRDLRRLVLQKPAQE

Download         Length: 408 bp

>T232666 NZ_CP127871:4577217-4577519 [Pseudomonas kurunegalensis]
ATGAAGAAAATAGAGTCCAGCAGTTTCAGACATTGGGTGGCCGGCCTGCGCGACGACAGCGCCAGAGCCCGAATCATTTC
CCGGATCAACCGATTGCTCGAAGGCCTCCCAGGCGATGTATCACCGGTTGGCTATGGCATCAGTGAACTCAGAATTCACT
GTGGGCCTGGTTACCGGGTGTATTTCCATCAGGCGGGCACAACGATTGTCATTCTGCTATGTGGCGGCGATAAAGGCAGC
CAACAACGAGACATCAAGGCAGCCCGCCAGATTCTGCGTTCGTGGAGGATGCAAAATGACTGA

Antitoxin


Download         Length: 89 a.a.        Molecular weight: 10480.98 Da        Isoelectric Point: 5.1116

>AT232666 WP_002916312.1 NZ_CP091068:880971-881237 [Klebsiella pneumoniae]
MDINNKARIHWACRRGMRELDISIMPFFEYEYDTLSDADKQLFIRLLENDDPDLFNWLMNHGKPADAELQRMVTLIQTRN
RERGPVAI

Download         Length: 267 bp

>AT232666 NZ_CP127871:4577512-4577805 [Pseudomonas kurunegalensis]
ATGACTGAAACCTTCTCTGAGTTCGATCCTGCCGAATACCTCACTACCCCTGAAGCCATCGCGTTGTTCATGACCGACGC
GCTTGAAACCGGAGACGCCAGCTATGTCGCCAAAGCTGTAGGCGTGGTGGCACGTGCAAAAGGTATGAGCGAGCTGGCCA
GAGAGACCGGACTGTCCCGAGAGCAGCTTTACAGGTCTTTCAGCGAACATGGCAACCCTACGCTCAAGTCTTTTCTAACG
GTGATGAAAGCATTGGGCATAGATATGACGGCGCGCCCCCACCTCGCCGGCTGA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A378E4P6

Antitoxin

Source ID Structure
AlphaFold DB A0A0H3GY41

References