232664

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) phd-doc/Doc-RelB
Location 343654..344240 Replicon chromosome
Accession NZ_CP091068
Organism Klebsiella pneumoniae strain WSCRKP

Toxin (Protein)


Gene name doc Uniprot ID W8VD46
Locus tag L0980_RS01600 Protein ID WP_002920800.1
Coordinates 343872..344240 (+) Length 123 a.a.

Antitoxin (Protein)


Gene name phd Uniprot ID W9B1V1
Locus tag L0980_RS01595 Protein ID WP_004174006.1
Coordinates 343654..343875 (+) Length 74 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0980_RS01575 (L0980_01575) 339811..340737 + 927 WP_002920807.1 high-affinity branched-chain amino acid ABC transporter permease LivH -
L0980_RS01580 (L0980_01580) 340734..342011 + 1278 WP_004174005.1 branched chain amino acid ABC transporter permease LivM -
L0980_RS01585 (L0980_01585) 342008..342775 + 768 WP_002920803.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivG -
L0980_RS01590 (L0980_01590) 342777..343490 + 714 WP_004145133.1 high-affinity branched-chain amino acid ABC transporter ATP-binding protein LivF -
L0980_RS01595 (L0980_01595) 343654..343875 + 222 WP_004174006.1 type II toxin-antitoxin system Phd/YefM family antitoxin Antitoxin
L0980_RS01600 (L0980_01600) 343872..344240 + 369 WP_002920800.1 type II toxin-antitoxin system death-on-curing family toxin Toxin
L0980_RS01605 (L0980_01605) 344513..345829 + 1317 WP_004174008.1 sn-glycerol-3-phosphate ABC transporter substrate-binding protein UgpB -
L0980_RS01610 (L0980_01610) 345936..346823 + 888 WP_002920792.1 sn-glycerol-3-phosphate ABC transporter permease UgpA -
L0980_RS01615 (L0980_01615) 346820..347665 + 846 WP_004181473.1 sn-glycerol-3-phosphate ABC transporter permease UgpE -
L0980_RS01620 (L0980_01620) 347667..348737 + 1071 WP_004150074.1 sn-glycerol-3-phosphate import ATP-binding protein UgpC -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
- inside Prophage - - 304017..349474 45457


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Fido domain

(13-86)

Antitoxin

Type II toxin-antitoxin system, antitoxin Phd/YefM

(1-50)


Sequences

Toxin        


Download         Length: 123 a.a.        Molecular weight: 13552.92 Da        Isoelectric Point: 8.6410

>T232664 WP_002920800.1 NZ_CP091068:343872-344240 [Klebsiella pneumoniae]
MTLQIISAEEIIQFHDRLLRVTPGVAGMPDPGRAEAIMYRVLNKIEYEGVTDVWRLAAMHLLAISRGHIFNDGNKRTALF
ITLLFLKRNGIILPANPDFVGMTVEAAAGQLTLEQIVARLRG

Download         Length: 369 bp

>T232664 NZ_CP127871:4182158-4182724 [Pseudomonas kurunegalensis]
GTGTCAGATCAAAACCTTCATGGAAAACTCGAGTTCCTGCGCCAGGCCGAAAAGCTCAAGAGCGTGACCCGCAGTGCCCA
CACCTCCACGGGCCGGCGTGAAAGTACCGCAGAGCACAGTTGGCGGCTGGCATTGCTGGCACTGGTGTTTGAAGAAGACC
TGGGTGATGTCGATATCTGCAAGGTGCTGAAGCTTTGCCTTGTCCATGACCTTGGGGAGGCCTTGAATGGCGATGTCCCC
GCCCCCGAGGCTCAGGCCATGCCCGACAAGGGAATGGGTGAACGGCAGGACCTGCTAGCCATCACATCGACGCTGGAACC
TTCGATGCAAGACAACATCGTTGCCTTGTTCGACGAGTACGAAGCGGCCACTTCGCCCGAAGCCAAGGTGGTCAAGGCAC
TCGACAAGATCGAAACCATCCTGCAGCACACCCAGGGCGATAACCCGCCTGGCTTCGACTACGCGTTCAACCTGGAATAC
GGCCGCCGTTATACGGATGCCATTCCATTCCTGGCTTCCCTAAGGCGCACACTCGATGACGAAACACGTCAACGCATGAC
AGGCTAA

Antitoxin


Download         Length: 74 a.a.        Molecular weight: 8151.15 Da        Isoelectric Point: 4.7769

>AT232664 WP_004174006.1 NZ_CP091068:343654-343875 [Klebsiella pneumoniae]
MRTVNYSEARQNLADVLESAVTGVPVTITRRGHKSAVIISAEEFERYQAARMDDEFAAIMAVHGDEIRELADK

Download         Length: 222 bp

>AT232664 NZ_CP127871:4181566-4182093 [Pseudomonas kurunegalensis]
ATGCTCAGGCACTGGCGCATGCTGAACCGGGTCAAGCAGCTGCACGCTGCGCAGATGTTCGGGGTGTGCCAGTCCACCGT
TTCCCGCTGGGAGTCTGGGATTCAGGACGCCGAGCCCGAGCAGCGCGCCCGCATCGAAGCCTTGCTCAAGGCCCGCCTCA
GCAGCGCTGCCGACCATGCACTGGCGCGGCTTGTATCGGGCAGCTCGCAACCCGTGCACCTGGTATGCGACCTCACCCAC
CGCCTGTTGGCCTGCTCAGCTCCCCGAGAAGCCGAGTTCCACGTCCCGGTCAGCGAGCTGCTGGGCGTTTCGCTGTGGCC
CTTTGCAACAGAGGAAATAGCCTCTCAGGAACAACGCCTGGCCGACATAGGCTGGCGGCAAAACCTGACCTCCCCGGCAC
TGGAGTTTGCCACTGGCGAGAACGACTCCGCGTTGGTGCCTATCCAGCACAGCCTTTGCCGCTGGACACGACTCACCCTG
TCGGATGGCTCGACTGCCCGGCTGGTCGAAACGCTCTCGCATATTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A0H3GUD1

Antitoxin

Source ID Structure
AlphaFold DB A0A5E5YJY7

References