Detailed information of TA system TA232651

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): tsbAT/-
• Location: 1915976..1916749
• Replicon: chromosome
• Accession: NZ_CP091066
• Organism: Staphylococcus aureus strain UMCG579

Toxin (Protein)

• Gene name: tsbT
• Uniprot ID: -
• Locus tag: L1O91_RS09245
• Protein ID: WP_054189550.1
• Coordinates: 1915976..1916125 (-)
• Length: 50 a.a.

Antitoxin (Protein)

• Gene name: tsbA
• Uniprot ID: A0A0D1IYN8
• Locus tag: L1O91_RS09250
• Protein ID: WP_001251219.1
• Coordinates: 1916150..1916749 (-)
• Length: 200 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1O91_RS09230 (1912047)	1912047..1912868	+	822	WP_054189552.1	RluA family pseudouridine synthase	-
L1O91_RS09235 (1913335)	1913335..1914720	-	1386	WP_054189551.1	class II fumarate hydratase	-
L1O91_RS09240 (1914916)	1914916..1915311	-	396	WP_000901023.1	hypothetical protein	-
L1O91_RS09245 (1915976)	1915976..1916125	-	150	WP_054189550.1	SAS053 family protein	Toxin
L1O91_RS09250 (1916150)	1916150..1916749	-	600	WP_001251219.1	glucosamine-6-phosphate isomerase	Antitoxin
L1O91_RS09255 (1916908)	1916908..1917378	-	471	WP_000181394.1	tRNA (uridine(34)/cytosine(34)/5- carboxymethylaminomethyluridine(34)-2'-O)- methyltransferase TrmL	-
L1O91_RS09260 (1917383)	1917383..1918510	-	1128	WP_054189549.1	tRNA epoxyqueuosine(34) reductase QueG	-
L1O91_RS09265 (1918661)	1918661..1919383	-	723	WP_054189583.1	amino acid ABC transporter ATP-binding protein	-
L1O91_RS09270 (1919376)	1919376..1920833	-	1458	WP_054189548.1	ABC transporter permease subunit	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Antitoxin

• Glucosamine-6-phosphate isomerase (124-196)

Sequences

Toxin

Protein

• Length: 50 a.a.
• Molecular weight: 5862.20 Da
• Isoelectric Point: 3.9075

>T232651 WP_054189550.1 NZ_CP091066:c1916125-1915976 [Staphylococcus aureus]
MSKDKDPKLNYHEEENSMVNDFEDLKELGKEMEQISDQNEQEKNSEEDN

Nucleotide

• Length: 150 bp

>T232651 NZ_CP127855:1058691-1059629 [Pseudoalteromonas sp. JC3]
ATGGATAAAGATAGCCCATATTACAAACAGGTTTCCTTGCTCATAAGAATGCTTCCTGTGGTAGCAACAGAGACGGTTTT
TGCACTTAAAGGTGGCACCGCCATTAATTTATTTGTGAGAGATTTTCCTCGGCTATCTGTAGATATTGATCTTGCTTATC
TTCCACTTGAACCAAGAGATGAGGCTTTGATTAATGTCAGGGCTGCATTGCAGCGCATTACAGACAGAATCAATACTCAA
CCAGATATCAGAGCGGCATTTCAGGATAATAAAGCTGATGAACTGAGAATCGTTGTATCAAGTCCGGTTGCGACGATCAA
AATTGAAGTGTCGCCCGTCGCCAGAGGTACATTGCATAGTGCAGAAATAATGCCAGTTCAAGAGTCTGTTGAAGACGAGT
TTGGTTATGCTGAGATTCAGGTAGTCAGTCTTCCCGATCTGTATGGTGGGAAATTGTGTGCTGCAATGGATCGCCAACAT
CCTCGCGACTTATTTGATGTGCGTATGTTACTTGGCAGTGAAGGGATTTCGAGAGAGATTTTGGTGGGTTTTTTAACCTA
TACATTAAGTCACCCTCGGCCTATTAATGAAGTCATGTCGCCAAACTGGCAGCCTCTGAATGAGAAATTTCAGGCAGAAT
TTGACGGAATGACTTTTGAAAAAGTTGAATGCGAAGACTTAGCCTCTGTTAGGCCCATGATGTTAATTGAACTGCAAAAA
CATTTCACAGAAAGAGATCATGCTTTCCTTATGTCATTCAAAAGAGGGCAACCTGACTGGGCATTGTTTGACTATCCTAA
TGCAGCAGACTTGCCAGCGATTCGTTGGAAATTGCAGAACATTAACAAATTGGCAAAGAATCAAGCAAAACACCAAGAGC
AATTAGATAAATTGAAGCAAGTGCTTGATGATTGGCTTGTTAACGCAAACGCCGAGTAA

Antitoxin

Protein

• Length: 200 a.a.
• Molecular weight: 22357.50 Da
• Isoelectric Point: 5.1445

>AT232651 WP_001251219.1 NZ_CP091066:c1916749-1916150 [Staphylococcus aureus]
MAMNFKVFDNSQLVAEYAADIIRKQFNNNPTTIAGFHLDTDQAPVLDELKKNIEKHAVDFSQINILDYDDKKSYFEALGV
PAGQVYPIAYEKDAIELIADKIKTKENKGKLTLQVVSIDEQGKLNVSIRQGLMEAREIFLVVTGANKRDVVEKLYQENGK
TSFEPADLKAHRMVNVILDKEAAAGLPEDVKAYFTSRFA

Nucleotide

• Length: 600 bp

>AT232651 NZ_CP127855:1057907-1058698 [Pseudoalteromonas sp. JC3]
ATGTCATCTAAGATAAACTGGCTTGTTGCTCATACTTCTCCTGGTGCGCTAGTACTTCAGCAATGGCTGACTGAAAACGG
TGTGAGCTATTCCTTGGCTCAAAAGTACGCGCAGAACGGTTGGCTAAAGAAGCTATGTTCTGGCGTGTATTATCGTCCAG
ATGCGCAGGGCGATATAAAGCCAACTTGGGTTGATGCCATTCAAGCATTAGATGTGCAATTGGGCGTTTCAGTTCATTTG
GCTGGATTGAGCAGCTTAACTCACCAAGGACTGAGTCACTATTTACAGCTGAACAAAGAGCAAGTTTGGATTTGCGTTAA
AAATAAGTCGTCCTTACCAAAATGGTTTCGTGAATTCCCTTATCAGAATTGGTTTTACTGTGGAAATCATAAGCTTGAAG
TGAATCCCGAGAAAGATTTGAAAAGGATCACGGTTAAAGAGAAAGAACTCACTGTCAGCTGTGCAGAACTTGCTGCCTAT
GAAGTGGTAGACGCTATTGGGAAGCTGATTTCATTTGAGCATGTCGCAGAATTATTTCAGGGTTTAGTCAATCTTAGCCC
TAGAAAAGTACAAGATATTCTTGAGCGAAGCAGCTCTGTGCAGGCAAACCGAATATTTCTATTTCTGGGTCGATACTACG
ATCACCAGTGGGTCAATCGCATAGATGAAACAAGAATTAAATTGGGTGCAGGAAAGCGGCAGGTTGTCGAAAAAGGACGT
TTTGATGAGCGATATCAAATCACAGTGCCAGAGATATTAAGCGTCAAAAAAGGTGAACAACATAATGGATAA

Structures

Antitoxin

• AlphaFold DB: A0A0D1IYN8