Detailed information of TA system
Overview
TA module
| Type | II | Classification (family/domain) | /HTH_19(antitoxin) |
| Location | 1490116..1490904 | Replicon | chromosome |
| Accession | NZ_CP091066 | ||
| Organism | Staphylococcus aureus strain UMCG579 | ||
Toxin (Protein)
| Gene name | - | Uniprot ID | A0A2I7Y5B3 |
| Locus tag | L1O91_RS07030 | Protein ID | WP_000525004.1 |
| Coordinates | 1490443..1490904 (+) | Length | 154 a.a. |
Antitoxin (Protein)
| Gene name | - | Uniprot ID | A0A0E7YIA0 |
| Locus tag | L1O91_RS07025 | Protein ID | WP_000333630.1 |
| Coordinates | 1490116..1490430 (+) | Length | 105 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| L1O91_RS06965 (1485258) | 1485258..1486424 | - | 1167 | WP_000762547.1 | DUF2800 domain-containing protein | - |
| L1O91_RS06970 (1486421) | 1486421..1486783 | - | 363 | WP_000985984.1 | hypothetical protein | - |
| L1O91_RS06975 (1486798) | 1486798..1487121 | - | 324 | WP_257552433.1 | TrmB family transcriptional regulator | - |
| L1O91_RS06980 (1487200) | 1487200..1487361 | - | 162 | WP_001285954.1 | DUF1270 domain-containing protein | - |
| L1O91_RS06985 (1487374) | 1487374..1487637 | - | 264 | WP_001124160.1 | helix-turn-helix domain-containing protein | - |
| L1O91_RS06990 (1487662) | 1487662..1487877 | - | 216 | WP_001097552.1 | hypothetical protein | - |
| L1O91_RS06995 (1487932) | 1487932..1488297 | + | 366 | WP_001128433.1 | hypothetical protein | - |
| L1O91_RS07000 (1488266) | 1488266..1488511 | - | 246 | WP_001025401.1 | DUF2829 domain-containing protein | - |
| L1O91_RS07005 (1488567) | 1488567..1488776 | + | 210 | WP_000642492.1 | hypothetical protein | - |
| L1O91_RS07010 (1488766) | 1488766..1488909 | - | 144 | WP_000939498.1 | hypothetical protein | - |
| L1O91_RS07015 (1488938) | 1488938..1489714 | - | 777 | WP_001148544.1 | Rha family transcriptional regulator | - |
| L1O91_RS07020 (1489728) | 1489728..1489964 | - | 237 | WP_001121027.1 | helix-turn-helix transcriptional regulator | - |
| L1O91_RS07025 (1490116) | 1490116..1490430 | + | 315 | WP_000333630.1 | helix-turn-helix transcriptional regulator | Antitoxin |
| L1O91_RS07030 (1490443) | 1490443..1490904 | + | 462 | WP_000525004.1 | hypothetical protein | Toxin |
| L1O91_RS07035 (1490922) | 1490922..1491356 | + | 435 | WP_000755718.1 | hypothetical protein | - |
| L1O91_RS07040 (1491385) | 1491385..1491780 | + | 396 | WP_000449655.1 | hypothetical protein | - |
| L1O91_RS07045 (1491870) | 1491870..1492016 | + | 147 | WP_001795334.1 | hypothetical protein | - |
| L1O91_RS07050 (1492013) | 1492013..1492627 | - | 615 | WP_000191466.1 | hypothetical protein | - |
| L1O91_RS07055 (1492753) | 1492753..1493958 | + | 1206 | WP_000264751.1 | site-specific integrase | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| - | inside | Prophage | dfrG | lukF-PV / lukS-PV | 1444029..1511597 | 67568 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 154 a.a. Molecular weight: 18074.46 Da Isoelectric Point: 4.6915
>T232646 WP_000525004.1 NZ_CP091066:1490443-1490904 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSKFNNRKFENYAR
RHGFISAVPLREIVEAYNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEYSITFEPLRVFKYKEI
Download Length: 462 bp
>T232646 NZ_CP127850:c62198-61782 [Escherichia coli]
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
GTGAACAAGACTTATATGCTTGATACCTGTATCTGCTCGTTCATCATGCGTGAACAGCCAGAAGCCGTCCTGAAGCGTCT
GGAGCAGGCGGTGCTACGCGGCCACCGTATAGTGGTCTCGGCCATCACCTACTCTGAAATGCGCTTCGGGGCTACCGGCC
CAAAGGCCTCACCACGTCACGTCCAACTGGTCGATGAATTCTGCGCCCGCCTCGATGCCATCCTGCCCTGGGATCGCGCC
GCAGTAGACGCCACCACGAAGATTAAAGTGGCACTGCGGCTGGCCGGGACGCCGATCGGCCCGAACGACACGGCGATTGC
CGGGCACGCCATCGCCGCCGGGGCGATACTGGTAACGAATAATACAAGAGAATTTGAGCGAGTGCCTGACCTGGTGCTGG
AAGACTGGGTGAAGTAA
Antitoxin
Download Length: 105 a.a. Molecular weight: 12063.56 Da Isoelectric Point: 6.4736
>AT232646 WP_000333630.1 NZ_CP091066:1490116-1490430 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK
Download Length: 315 bp
>AT232646 NZ_CP127850:c62425-62195 [Escherichia coli]
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
ATGAGAACCGTATCGATATTTAAAAATGGCAACAACCGCGCCATCCGTCTGCCTCGTGATCTGGATTTTGAGGGGGTGAG
CGAGCTCGAGATCGTCCGGGAAGGGGACAGCATCATCCTGCGCCCCGTCCGGCCAACCTGGGGATCATTCCTAGAGTACG
AAAAAGCCGATCCAGATTTTATGGCGGAGCGCGAGGATGTTGTCAGCGACGAAGGGCGATTTAACCTGTGA
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
Structures
Toxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A2I7Y5B3 |
Antitoxin
| Source | ID | Structure |
|---|---|---|
| AlphaFold DB | A0A0E7YIA0 |