Detailed information of TA system TA232642

Bioinformatically predicted

Overview

TA module

• Type: II
• Classification (family/domain): TsaAT/-
• Location: 784427..784904
• Replicon: chromosome
• Accession: NZ_CP091066
• Organism: Staphylococcus aureus strain UMCG579

Toxin (Protein)

• Gene name: TsaT
• Uniprot ID: T1Y7S2
• Locus tag: L1O91_RS03660
• Protein ID: WP_000052076.1
• Coordinates: 784427..784615 (-)
• Length: 63 a.a.

Antitoxin (Protein)

• Gene name: TsaA
• Uniprot ID: -
• Locus tag: L1O91_RS03665
• Protein ID: WP_001059689.1
• Coordinates: 784644..784904 (-)
• Length: 87 a.a.

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1O91_RS03630 (780377)	780377..780934	+	558	WP_054189291.1	hypothetical protein	-
L1O91_RS03635 (781276)	781276..781962	+	687	WP_054189292.1	thermonuclease family protein	-
L1O91_RS03640 (782319)	782319..782519	+	201	WP_001059082.1	cold-shock protein	-
L1O91_RS03645 (783017)	783017..783235	-	219	WP_054189293.1	hypothetical protein	-
L1O91_RS03650 (783297)	783297..783581	-	285	WP_054189294.1	hypothetical protein	-
L1O91_RS03655 (783669)	783669..784238	-	570	WP_054189295.1	lipoprotein N-acylation protein LnsA	-
L1O91_RS03660 (784427)	784427..784615	-	189	WP_000052076.1	hypothetical protein	Toxin
L1O91_RS03665 (784644)	784644..784904	-	261	WP_001059689.1	hypothetical protein	Antitoxin
L1O91_RS03670 (785245)	785245..785448	+	204	WP_000145163.1	sterile alpha motif-like domain-containing protein	-
L1O91_RS03675 (785445)	785445..785681	-	237	WP_000368687.1	hypothetical protein	-
L1O91_RS03680 (785905)	785905..786486	+	582	WP_054189296.1	histidine phosphatase family protein	-
L1O91_RS03685 (786559)	786559..787176	-	618	WP_054189297.1	LysE/ArgO family amino acid transporter	-
L1O91_RS03690 (787332)	787332..787826	-	495	WP_054189298.1	GNAT family N-acetyltransferase	-
L1O91_RS03695 (788225)	788225..788647	-	423	WP_000974455.1	organic hydroperoxide resistance protein	-
L1O91_RS03700 (788795)	788795..789511	+	717	WP_054189299.1	type I 3-dehydroquinate dehydratase	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin GhoT/OrtT (4-57)

Antitoxin

• Endoribonuclease antitoxin GhoS (5-94)

Sequences

Toxin

Protein

• Length: 63 a.a.
• Molecular weight: 7142.82 Da
• Isoelectric Point: 9.9971

>T232642 WP_000052076.1 NZ_CP091066:c784615-784427 [Staphylococcus aureus]
MSLHFAILFWLALIFLVAATFILVLMKKTGKESKKESYLSFTVILYIFGFAILIYTFIFGVL

Nucleotide

• Length: 189 bp

>T232642 NZ_CP127848:c4182845-4182672 [Escherichia coli]
ATGGCACTATTCTCTAAAATATTAATTTTTTATGTGATTGGTGTGAACATATCCTTTGTCATTATCTGGTTTATCTCACA
TGAGAAAACACATATTCGTTTACTTAGTGCATTCCTGGTCGGAATAACCTGGCCAATGAGTCTGCCTGTGGCATTACTTT
TTTCTCTCTTTTAG

Antitoxin

Protein

• Length: 87 a.a.
• Molecular weight: 10009.20 Da
• Isoelectric Point: 4.4986

>AT232642 WP_001059689.1 NZ_CP091066:c784904-784644 [Staphylococcus aureus]
MNNILLNAINIVITTTFVIFNILITYNKDLDDLCWLLPGIIICGVILIVSFTIAMITKNWLSEILFFINIVLVLYYIYPI
FYRFIG

Nucleotide

• Length: 261 bp

>AT232642 NZ_CP127848:c4183169-4182873 [Escherichia coli]
ATGGAAGGTAAAAACAAGTTCAATACTTATGTTGTTTCTTTTAATTATCCATCATCTTATTCCTCAGTGTTCTTAAGGTT
AAGATCATTGATGTATGATATGAATTTCTCCTCTATCGTGGCTGATGAATATGGGATACCACGACAATTGAATGAAAACT
CCTTCGCAATAACGACATCGTTAGCCGCAAGTGAAATCGAAGATTTAATCAGGCTTAAATGCTTAGACTTACCGGATATT
GACTTTGACCTCAACATTATGACAGTTGATGACTATTTCCGTCAGTTTTACAAGTAG

Structures

Toxin

• AlphaFold DB: A0A0E0VP18