Detailed information of TA system
Bioinformatically predictedOverview
TA module
Type | II | Classification (family/domain) | hicAB/- |
Location | 3869482..3870113 | Replicon | chromosome |
Accession | NC_011601 | ||
Organism | Escherichia coli O127:H6 str. E2348/69 |
Toxin (Protein)
Gene name | hicA | Uniprot ID | L4J012 |
Locus tag | E2348C_RS19985 | Protein ID | WP_001260301.1 |
Coordinates | 3869838..3870113 (-) | Length | 92 a.a. |
Antitoxin (Protein)
Gene name | hicB | Uniprot ID | U9Y7E1 |
Locus tag | E2348C_RS19980 | Protein ID | WP_000593555.1 |
Coordinates | 3869482..3869841 (-) | Length | 120 a.a. |
Genomic Context
Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
---|---|---|---|---|---|---|
E2348C_RS19955 (E2348_C_3718) | 3865614..3866558 | + | 945 | WP_000947070.1 | nickel ABC transporter permease subunit NikB | - |
E2348C_RS19960 (E2348_C_3719) | 3866555..3867388 | + | 834 | WP_001008954.1 | nickel ABC transporter permease subunit NikC | - |
E2348C_RS19965 (E2348_C_3720) | 3867388..3868152 | + | 765 | WP_001136232.1 | nickel import ATP-binding protein NikD | - |
E2348C_RS19970 (E2348_C_3721) | 3868149..3868955 | + | 807 | WP_000173679.1 | nickel import ATP-binding protein NikE | - |
E2348C_RS19975 (E2348_C_3722) | 3868961..3869362 | + | 402 | WP_001190063.1 | nickel-responsive transcriptional regulator NikR | - |
E2348C_RS19980 (E2348_C_3723) | 3869482..3869841 | - | 360 | WP_000593555.1 | type II toxin-antitoxin system HicB family antitoxin | Antitoxin |
E2348C_RS19985 (E2348_C_3724) | 3869838..3870113 | - | 276 | WP_001260301.1 | type II toxin-antitoxin system HicA family toxin | Toxin |
E2348C_RS19990 (E2348_C_3725) | 3870186..3871310 | - | 1125 | WP_001314210.1 | ABC transporter permease | - |
E2348C_RS19995 (E2348_C_3726) | 3871310..3874045 | - | 2736 | WP_000149096.1 | ribosome-associated ATPase/putative transporter RbbA | - |
E2348C_RS20000 (E2348_C_3727) | 3874042..3875109 | - | 1068 | WP_000361455.1 | HlyD family secretion protein | - |
Associated MGEs
MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 92 a.a. Molecular weight: 10185.87 Da Isoelectric Point: 10.6128
>T23264 WP_001260301.1 NC_011601:c3870113-3869838 [Escherichia coli O127:H6 str. E2348/69]
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
MRTQVQALRKKQKNTLDQIFKSPVPQGIKWSDIESLVKALGGEIKEGRGSRCKFILNMSVACFHRPHPSPDTDKGAVESV
RDWLLSIGVKP
Download Length: 276 bp
>T23264 NC_011601:c3870113-3869838 [Escherichia coli O127:H6 str. E2348/69]
ATGAGAACCCAGGTACAGGCTTTGCGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
ATGAGAACCCAGGTACAGGCTTTGCGGAAGAAACAAAAAAATACATTGGATCAAATATTTAAATCTCCTGTTCCTCAAGG
GATTAAGTGGTCTGATATAGAGTCACTGGTTAAAGCATTAGGCGGAGAAATTAAGGAAGGAAGAGGTTCGCGTTGTAAGT
TCATACTAAATATGAGCGTTGCGTGTTTCCATCGGCCTCATCCGTCGCCAGATACCGATAAAGGCGCTGTAGAAAGCGTG
CGTGACTGGTTACTAAGTATAGGGGTAAAACCATGA
Antitoxin
Download Length: 120 a.a. Molecular weight: 13402.27 Da Isoelectric Point: 5.1987
>AT23264 WP_000593555.1 NC_011601:c3869841-3869482 [Escherichia coli O127:H6 str. E2348/69]
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
MIKLKTPNSMEIAGQPAVITYVPELNAFRGKFLGLSGYCDFVSDSIQGLQKEGELSLREYLEDCKAAGIEPYARTEKIKT
FTLRYPESLSERLNNAAAQQQVSVNTYIIETLNERLNHL
Download Length: 360 bp
>AT23264 NC_011601:c3869841-3869482 [Escherichia coli O127:H6 str. E2348/69]
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA
ATGATCAAACTGAAGACGCCAAACTCTATGGAGATTGCCGGGCAACCTGCTGTTATCACTTACGTGCCAGAACTGAATGC
ATTTCGTGGCAAATTCCTGGGCTTGTCAGGTTATTGTGATTTTGTCTCTGACAGCATTCAGGGGCTGCAAAAAGAAGGGG
AGCTTTCCCTGCGAGAGTATCTTGAGGATTGTAAAGCTGCGGGTATTGAGCCGTATGCGCGTACAGAAAAGATTAAGACC
TTTACATTACGCTATCCAGAATCGCTGAGTGAACGCCTTAATAATGCGGCTGCGCAGCAACAAGTCTCTGTAAATACTTA
TATTATTGAAACGCTAAATGAGCGTTTGAATCATTTATAA
Similar Proteins
Only experimentally validated proteins are listed.
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
---|
Structures
Toxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | L4J012 |
Antitoxin
Source | ID | Structure |
---|---|---|
AlphaFold DB | A0A7U9LKZ6 |